ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Megakaryocyte and platelet inhibitory receptor G6b

Intramolecular
Cysteine 35 and cysteine 108
Cysteine 53 and cysteine 129
A redox-regulated disulphide may form within Megakaryocyte and platelet inhibitory receptor G6b between cysteines 35 and 108.

Details

Redox score ?
83
PDB code
6r0x
Structure name
the extracellular domain of g6b-b in complex with fab fragment and dp12 heparin oligosaccharide
Structure deposition date
2019-03-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95866
Residue number A
35
Residue number B
108
Peptide name
Megakaryocyte and platelet inhibitory receptor G6b

Ligandability

Cysteine 35 of Megakaryocyte and platelet inhibitory receptor G6b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Megakaryocyte and platelet inhibitory receptor G6b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Megakaryocyte and platelet inhibitory receptor G6b between cysteines 53 and 129.

Details

Redox score ?
63
PDB code
6r0x
Structure name
the extracellular domain of g6b-b in complex with fab fragment and dp12 heparin oligosaccharide
Structure deposition date
2019-03-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
O95866
Residue number A
53
Residue number B
129
Peptide name
Megakaryocyte and platelet inhibitory receptor G6b

Ligandability

Cysteine 53 of Megakaryocyte and platelet inhibitory receptor G6b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of Megakaryocyte and platelet inhibitory receptor G6b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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