ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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WD repeat-containing and planar cell polarity effector protein fritz homolog

Intramolecular
Cysteine 317 and cysteine 328
Cysteine 344 and cysteine 385
Cysteine 116 and cysteine 127
Cysteine 343 and cysteine 344
Cysteine 273 and cysteine 325
Cysteine 273 and cysteine 312
Cysteine 343 and cysteine 356
A redox-regulated disulphide may form within WD repeat-containing and planar cell polarity effector protein fritz homolog between cysteines 317 and 328.

Details

Redox score ?
71
PDB code
7q3d
Structure name
structure of the human cplane complex
Structure deposition date
2021-10-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
36
Peptide accession
O95876
Residue number A
317
Residue number B
328
Peptide name
WD repeat-containing and planar cell polarity effector protein fritz homolog

Ligandability

Cysteine 317 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing and planar cell polarity effector protein fritz homolog between cysteines 344 and 385.

Details

Redox score ?
70
PDB code
7q3d
Structure name
structure of the human cplane complex
Structure deposition date
2021-10-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
8
% buried
98
Peptide accession
O95876
Residue number A
344
Residue number B
385
Peptide name
WD repeat-containing and planar cell polarity effector protein fritz homolog

Ligandability

Cysteine 344 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 385 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing and planar cell polarity effector protein fritz homolog between cysteines 116 and 127. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7q3d
Structure name
structure of the human cplane complex
Structure deposition date
2021-10-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
94
Peptide accession
O95876
Residue number A
116
Residue number B
127
Peptide name
WD repeat-containing and planar cell polarity effector protein fritz homolog

Ligandability

Cysteine 116 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing and planar cell polarity effector protein fritz homolog between cysteines 343 and 344. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7q3d
Structure name
structure of the human cplane complex
Structure deposition date
2021-10-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
99
Peptide accession
O95876
Residue number A
343
Residue number B
344
Peptide name
WD repeat-containing and planar cell polarity effector protein fritz homolog

Ligandability

Cysteine 343 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 344 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing and planar cell polarity effector protein fritz homolog between cysteines 273 and 325. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7q3e
Structure name
structure of the mouse cplane-rsg1 complex
Structure deposition date
2021-10-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
57
Peptide accession
Q8C456
Residue number A
273
Residue number B
325
Peptide name
WD repeat-containing and planar cell polarity effector protein fritz homolog

Ligandability

Cysteine 273 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing and planar cell polarity effector protein fritz homolog between cysteines 273 and 312. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7q3e
Structure name
structure of the mouse cplane-rsg1 complex
Structure deposition date
2021-10-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
76
Peptide accession
Q8C456
Residue number A
273
Residue number B
312
Peptide name
WD repeat-containing and planar cell polarity effector protein fritz homolog

Ligandability

Cysteine 273 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing and planar cell polarity effector protein fritz homolog between cysteines 343 and 356. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7q3d
Structure name
structure of the human cplane complex
Structure deposition date
2021-10-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
82
Peptide accession
O95876
Residue number A
343
Residue number B
356
Peptide name
WD repeat-containing and planar cell polarity effector protein fritz homolog

Ligandability

Cysteine 343 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of WD repeat-containing and planar cell polarity effector protein fritz homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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