ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Natural cytotoxicity triggering receptor 2

Intramolecular
Cysteine 55 and cysteine 63
Cysteine 40 and cysteine 109
Cysteine 55 and cysteine 109
Cysteine 63 and cysteine 109
A redox-regulated disulphide may form within Natural cytotoxicity triggering receptor 2 between cysteines 55 and 63 (37 and 45 respectively in this structure).

Details

Redox score ?
85
PDB code
1hkf
Structure name
the three dimensional structure of nk cell receptor nkp44, a triggering partner in natural cytotoxicity
Structure deposition date
2003-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95944
Residue number A
55
Residue number B
63
Peptide name
Natural cytotoxicity triggering receptor 2

Ligandability

Cysteine 55 of Natural cytotoxicity triggering receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 63 of Natural cytotoxicity triggering receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Natural cytotoxicity triggering receptor 2 between cysteines 40 and 109 (22 and 91 respectively in this structure).

Details

Redox score ?
80
PDB code
1hkf
Structure name
the three dimensional structure of nk cell receptor nkp44, a triggering partner in natural cytotoxicity
Structure deposition date
2003-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95944
Residue number A
40
Residue number B
109
Peptide name
Natural cytotoxicity triggering receptor 2

Ligandability

Cysteine 40 of Natural cytotoxicity triggering receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Natural cytotoxicity triggering receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Natural cytotoxicity triggering receptor 2 between cysteines 55 and 109 (37 and 91 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1hkf
Structure name
the three dimensional structure of nk cell receptor nkp44, a triggering partner in natural cytotoxicity
Structure deposition date
2003-03-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95944
Residue number A
55
Residue number B
109
Peptide name
Natural cytotoxicity triggering receptor 2

Ligandability

Cysteine 55 of Natural cytotoxicity triggering receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Natural cytotoxicity triggering receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Natural cytotoxicity triggering receptor 2 between cysteines 63 and 109 (45 and 91 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1hkf
Structure name
the three dimensional structure of nk cell receptor nkp44, a triggering partner in natural cytotoxicity
Structure deposition date
2003-03-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O95944
Residue number A
63
Residue number B
109
Peptide name
Natural cytotoxicity triggering receptor 2

Ligandability

Cysteine 63 of Natural cytotoxicity triggering receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Natural cytotoxicity triggering receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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