ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Formimidoyltransferase-cyclodeaminase

Intramolecular
Cysteine 7 and cysteine 91
Cysteine 33 and cysteine 57
Cysteine 104 and cysteine 107
Cysteine 7 and cysteine 33
Cysteine 7 and cysteine 107
Cysteine 7 and cysteine 104
A redox-regulated disulphide may form within Formimidoyltransferase-cyclodeaminase between cysteines 7 and 91.

Details

Redox score ?
66
PDB code
1qd1
Structure name
the crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase
Structure deposition date
1999-07-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
97
Minimum pKa ?
10
% buried
100
Peptide accession
P53603
Residue number A
7
Residue number B
91
Peptide name
Formimidoyltransferase-cyclodeaminase

Ligandability

Cysteine 7 of Formimidoyltransferase-cyclodeaminase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Formimidoyltransferase-cyclodeaminase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Formimidoyltransferase-cyclodeaminase between cysteines 33 and 57. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
2pfd
Structure name
anisotropically refined structure of ftcd
Structure deposition date
2007-04-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
41
Peptide accession
O88618
Residue number A
33
Residue number B
57
Peptide name
Formimidoyltransferase-cyclodeaminase

Ligandability

Cysteine 33 of Formimidoyltransferase-cyclodeaminase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 57 of Formimidoyltransferase-cyclodeaminase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Formimidoyltransferase-cyclodeaminase between cysteines 104 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
2pfd
Structure name
anisotropically refined structure of ftcd
Structure deposition date
2007-04-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
68
Peptide accession
O88618
Residue number A
104
Residue number B
107
Peptide name
Formimidoyltransferase-cyclodeaminase

Ligandability

Cysteine 104 of Formimidoyltransferase-cyclodeaminase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Formimidoyltransferase-cyclodeaminase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Formimidoyltransferase-cyclodeaminase between cysteines 7 and 33. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2pfd
Structure name
anisotropically refined structure of ftcd
Structure deposition date
2007-04-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
78
Peptide accession
O88618
Residue number A
7
Residue number B
33
Peptide name
Formimidoyltransferase-cyclodeaminase

Ligandability

Cysteine 7 of Formimidoyltransferase-cyclodeaminase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 33 of Formimidoyltransferase-cyclodeaminase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Formimidoyltransferase-cyclodeaminase between cysteines 7 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
2pfd
Structure name
anisotropically refined structure of ftcd
Structure deposition date
2007-04-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
80
Peptide accession
O88618
Residue number A
7
Residue number B
107
Peptide name
Formimidoyltransferase-cyclodeaminase

Ligandability

Cysteine 7 of Formimidoyltransferase-cyclodeaminase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Formimidoyltransferase-cyclodeaminase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Formimidoyltransferase-cyclodeaminase between cysteines 7 and 104. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
1qd1
Structure name
the crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase
Structure deposition date
1999-07-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
75
Peptide accession
P53603
Residue number A
7
Residue number B
104
Peptide name
Formimidoyltransferase-cyclodeaminase

Ligandability

Cysteine 7 of Formimidoyltransferase-cyclodeaminase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Formimidoyltransferase-cyclodeaminase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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