ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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B-cell lymphoma/leukemia 10

Intermolecular
Cysteine 57 and cysteine 57
A redox-regulated disulphide may form between two units of B-cell lymphoma/leukemia 10 at cysteines 57 and 57. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
8czo
Structure name
cryo-em structure of bcl10 card - malt1 dd filament
Structure deposition date
2022-05-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
32
Peptide A name
B-cell lymphoma/leukemia 10
Peptide B name
B-cell lymphoma/leukemia 10
Peptide A accession
O95999
Peptide B accession
O95999
Peptide A residue number
57
Peptide B residue number
57

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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