a tool for identifying drug-targetable redox-active disulphides

E3 SUMO-protein ligase ZBED1

Intramolecular

Cysteine 47 and cysteine 50

A redox-regulated disulphide may form within E3 SUMO-protein ligase ZBED1 between cysteines 47 and 50 (32 and 35 respectively in this structure).

Details

Redox score ?

81

PDB code

Structure name

solution structure of the zinc finger bed domain of the zinc finger bed domain containing protein 1

Structure deposition date

2005-05-23

Thiol separation (Å)

4

Half-sphere exposure sum ?

44

Minimum pK_a ?

9

% buried

10

Peptide accession

Residue number A

47

Residue number B

50

Peptide name

E3 SUMO-protein ligase ZBED1

Ligandability

Cysteine 47 of E3 SUMO-protein ligase ZBED1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 50 of E3 SUMO-protein ligase ZBED1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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