a tool for identifying drug-targetable redox-active disulphides

Mitochondrial import receptor subunit TOM40 homolog

Intermolecular

Cysteine 354 and cysteine 354 L

A redox-regulated disulphide may form between two units of Mitochondrial import receptor subunit TOM40 homolog at cysteines 354 and 354. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

56

PDB code

Structure name

human tom complex with cross-linking

Structure deposition date

2021-09-06

Thiol separation (Å)

5

Half-sphere exposure sum ?

89

Minimum pK_a ?

12

% buried

82

Peptide A name

Mitochondrial import receptor subunit TOM40 homolog

Peptide B name

Mitochondrial import receptor subunit TOM40 homolog

Peptide A accession

Peptide B accession

Peptide A residue number

354

Peptide B residue number

354

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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