ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Actin-like protein 6A

Intramolecular
Cysteine 206 and cysteine 255 L
Cysteine 206 and cysteine 295 L
Cysteine 255 and cysteine 257
A redox-regulated disulphide may form within Actin-like protein 6A between cysteines 206 and 255. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7vdv
Structure name
the overall structure of human chromatin remodeling pbaf-nucleosome complex
Structure deposition date
2021-09-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
53
Peptide accession
O96019
Residue number A
206
Residue number B
255
Peptide name
Actin-like protein 6A

Ligandability

Cysteine 206 of Actin-like protein 6A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 255 of Actin-like protein 6A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-like protein 6A between cysteines 206 and 295. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7vdv
Structure name
the overall structure of human chromatin remodeling pbaf-nucleosome complex
Structure deposition date
2021-09-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
44
Peptide accession
O96019
Residue number A
206
Residue number B
295
Peptide name
Actin-like protein 6A

Ligandability

Cysteine 206 of Actin-like protein 6A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Actin-like protein 6A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-like protein 6A between cysteines 255 and 257. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7vdv
Structure name
the overall structure of human chromatin remodeling pbaf-nucleosome complex
Structure deposition date
2021-09-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
64
Peptide accession
O96019
Residue number A
255
Residue number B
257
Peptide name
Actin-like protein 6A

Ligandability

Cysteine 255 of Actin-like protein 6A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 257 of Actin-like protein 6A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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