Glutathione reductase, mitochondrial

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Glutathione reductase, mitochondrial at cysteines 134 and 134 (90 and 90 respectively in this structure).

Details

Redox score ?

PDB code

3sqp

Structure name

structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity

Structure deposition date

2011-07-06

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Glutathione reductase, mitochondrial

Peptide B name

Glutathione reductase, mitochondrial

Peptide A accession

P00390

Peptide B accession

P00390

Peptide A residue number

134

Peptide B residue number

134

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutathione reductase, mitochondrial between cysteines 102 and 107 (58 and 63 respectively in this structure).

Details

Redox score ?

PDB code

1grh

Structure name

inhibition of human glutathione reductase by the nitrosourea drugs 1, 3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2- hydroxyethyl)-1-nitrosourea

Structure deposition date

1992-12-15

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P00390

Residue number A

102

Residue number B

107

Peptide name

Glutathione reductase, mitochondrial

Ligandability

Cysteine 102 of Glutathione reductase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Glutathione reductase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutathione reductase, mitochondrial between cysteines 461 and 484 (417 and 440 respectively in this structure).