ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ceruloplasmin

Intramolecular
Cysteine 276 and cysteine 357
Cysteine 637 and cysteine 718
Cysteine 534 and cysteine 560
Cysteine 174 and cysteine 200
Cysteine 874 and cysteine 900
A redox-regulated disulphide may form within Ceruloplasmin between cysteines 276 and 357 (257 and 338 respectively in this structure).

Details

Redox score ?
87
PDB code
1kcw
Structure name
x-ray crystal structure of human ceruloplasmin at 3
Structure deposition date
1996-09-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00450
Residue number A
276
Residue number B
357
Peptide name
Ceruloplasmin

Ligandability

Cysteine 276 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 357 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ceruloplasmin between cysteines 637 and 718 (618 and 699 respectively in this structure).

Details

Redox score ?
82
PDB code
4ejx
Structure name
structure of ceruloplasmin-myeloperoxidase complex
Structure deposition date
2012-04-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00450
Residue number A
637
Residue number B
718
Peptide name
Ceruloplasmin

Ligandability

Cysteine 637 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 718 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ceruloplasmin between cysteines 534 and 560 (515 and 541 respectively in this structure).

Details

Redox score ?
81
PDB code
1kcw
Structure name
x-ray crystal structure of human ceruloplasmin at 3
Structure deposition date
1996-09-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00450
Residue number A
534
Residue number B
560
Peptide name
Ceruloplasmin

Ligandability

Cysteine 534 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 560 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ceruloplasmin between cysteines 174 and 200 (155 and 181 respectively in this structure).

Details

Redox score ?
78
PDB code
1kcw
Structure name
x-ray crystal structure of human ceruloplasmin at 3
Structure deposition date
1996-09-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00450
Residue number A
174
Residue number B
200
Peptide name
Ceruloplasmin

Ligandability

Cysteine 174 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ceruloplasmin between cysteines 874 and 900 (855 and 881 respectively in this structure).

Details

Redox score ?
78
PDB code
4enz
Structure name
structure of human ceruloplasmin at 2
Structure deposition date
2012-04-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00450
Residue number A
874
Residue number B
900
Peptide name
Ceruloplasmin

Ligandability

Cysteine 874 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 900 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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