Hypoxanthine-guanine phosphoribosyltransferase

Intermolecular

A redox-regulated disulphide may form between two units of Hypoxanthine-guanine phosphoribosyltransferase at cysteines 66 and 66 (65 and 65 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

4rad

Structure name

aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, plasmodium falciparum and vivax 6- oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents

Structure deposition date

2014-09-10

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide A name

Hypoxanthine-guanine phosphoribosyltransferase

Peptide B name

Hypoxanthine-guanine phosphoribosyltransferase

Peptide A accession