ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tyrosine-protein kinase ABL1

Intermolecular
Cysteine 330 and cysteine 330
A redox-regulated disulphide may form between two units of Tyrosine-protein kinase ABL1 at cysteines 330 and 330. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
2hyy
Structure name
human abl kinase domain in complex with imatinib (sti571, glivec)
Structure deposition date
2006-08-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
62
Peptide A name
Tyrosine-protein kinase ABL1
Peptide B name
Tyrosine-protein kinase ABL1
Peptide A accession
P00519
Peptide B accession
P00519
Peptide A residue number
330
Peptide B residue number
330

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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