ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Urokinase-type plasminogen activator

Intermolecular
Cysteine 168 and cysteine 299
Cysteine 315 and cysteine 219
Intramolecular
Cysteine 33 and cysteine 51
Cysteine 53 and cysteine 62
Cysteine 70 and cysteine 151
Cysteine 313 and cysteine 382
Cysteine 217 and cysteine 288
Cysteine 91 and cysteine 133
Cysteine 122 and cysteine 146
Cysteine 345 and cysteine 361
More...
Cysteine 209 and cysteine 225
Cysteine 372 and cysteine 400
Cysteine 33 and cysteine 39
Cysteine 31 and cysteine 39
Cysteine 31 and cysteine 33
Cysteine 91 and cysteine 122
Cysteine 33 and cysteine 62
Cysteine 91 and cysteine 146
Cysteine 39 and cysteine 51
Cysteine 122 and cysteine 133
Cysteine 51 and cysteine 62
Cysteine 33 and cysteine 53
Cysteine 133 and cysteine 146
Cysteine 31 and cysteine 51
Cysteine 51 and cysteine 53
Cysteine 31 and cysteine 62
Cysteine 31 and cysteine 53
Cysteine 39 and cysteine 62
Cysteine 70 and cysteine 146
Cysteine 39 and cysteine 53
A redox-regulated disulphide may form between two units of Urokinase-type plasminogen activator at cysteines 168 and 299 (13 and 122 respectively in this structure).

Details

Redox score ?
81
PDB code
1o5c
Structure name
dissecting and designing inhibitor selectivity determinants at the s1 site using an artificial ala190 protease (ala190 upa)
Structure deposition date
2003-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide A name
Urokinase-type plasminogen activator
Peptide B name
Urokinase-type plasminogen activator
Peptide A accession
P00749
Peptide B accession
P00749
Peptide A residue number
168
Peptide B residue number
299

Ligandability

Cysteine 168 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Urokinase-type plasminogen activator at cysteines 315 and 219 (136 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6a8n
Structure name
the crystal structure of mupain-1-ig-2 in complex with mupa-spd at ph8
Structure deposition date
2018-07-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide A name
Urokinase-type plasminogen activator
Peptide B name
Urokinase-type plasminogen activator
Peptide A accession
P06869
Peptide B accession
P06869
Peptide A residue number
315
Peptide B residue number
219

Ligandability

Cysteine 315 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 33 and 51 (13 and 31 respectively in this structure).

Details

Redox score ?
85
PDB code
4k24
Structure name
structure of anti-upar fab atn-658 in complex with upar
Structure deposition date
2013-04-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
33
Residue number B
51
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 33 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 53 and 62 (33 and 42 respectively in this structure).

Details

Redox score ?
84
PDB code
4k24
Structure name
structure of anti-upar fab atn-658 in complex with upar
Structure deposition date
2013-04-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
53
Residue number B
62
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 53 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 62 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 70 and 151 (50 and 131 respectively in this structure).

Details

Redox score ?
84
PDB code
2i9a
Structure name
crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (atf)
Structure deposition date
2006-09-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
70
Residue number B
151
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 70 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 313 and 382 (136 and 201 respectively in this structure).

Details

Redox score ?
84
PDB code
2nwn
Structure name
new pharmacophore for serine protease inhibition revealed by crystal structure of human urokinase-type plasminogen activator complexed with a cyclic peptidyl inhibitor, upain-1
Structure deposition date
2006-11-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q53XS3
Residue number A
313
Residue number B
382
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 313 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 217 and 288 (50 and 111 respectively in this structure).

Details

Redox score ?
83
PDB code
2nwn
Structure name
new pharmacophore for serine protease inhibition revealed by crystal structure of human urokinase-type plasminogen activator complexed with a cyclic peptidyl inhibitor, upain-1
Structure deposition date
2006-11-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q53XS3
Residue number A
217
Residue number B
288
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 217 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 288 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 91 and 133 (71 and 113 respectively in this structure).

Details

Redox score ?
82
PDB code
2i9a
Structure name
crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (atf)
Structure deposition date
2006-09-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
91
Residue number B
133
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 91 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 122 and 146 (102 and 126 respectively in this structure).

Details

Redox score ?
82
PDB code
2i9a
Structure name
crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (atf)
Structure deposition date
2006-09-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
122
Residue number B
146
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 122 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 146 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 345 and 361 (168 and 182 respectively in this structure).

Details

Redox score ?
81
PDB code
2nwn
Structure name
new pharmacophore for serine protease inhibition revealed by crystal structure of human urokinase-type plasminogen activator complexed with a cyclic peptidyl inhibitor, upain-1
Structure deposition date
2006-11-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q53XS3
Residue number A
345
Residue number B
361
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 345 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 209 and 225 (42 and 58 respectively in this structure).

Details

Redox score ?
79
PDB code
2nwn
Structure name
new pharmacophore for serine protease inhibition revealed by crystal structure of human urokinase-type plasminogen activator complexed with a cyclic peptidyl inhibitor, upain-1
Structure deposition date
2006-11-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
97
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q53XS3
Residue number A
209
Residue number B
225
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 209 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 225 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 372 and 400 (191 and 220 respectively in this structure).

Details

Redox score ?
78
PDB code
2nwn
Structure name
new pharmacophore for serine protease inhibition revealed by crystal structure of human urokinase-type plasminogen activator complexed with a cyclic peptidyl inhibitor, upain-1
Structure deposition date
2006-11-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q53XS3
Residue number A
372
Residue number B
400
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 372 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 400 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 33 and 39 (13 and 19 respectively in this structure).

Details

Redox score ?
77
PDB code
2i9a
Structure name
crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (atf)
Structure deposition date
2006-09-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
33
Residue number B
39
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 33 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 39 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 31 and 39 (11 and 19 respectively in this structure).

Details

Redox score ?
76
PDB code
2fd6
Structure name
structure of human urokinase plasminogen activator in complex with urokinase receptor and an anti-upar antibody at 1
Structure deposition date
2005-12-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
nan
Peptide accession
P00749
Residue number A
31
Residue number B
39
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 31 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 39 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 31 and 33 (11 and 13 respectively in this structure).

Details

Redox score ?
72
PDB code
4k24
Structure name
structure of anti-upar fab atn-658 in complex with upar
Structure deposition date
2013-04-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
31
Residue number B
33
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 31 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 33 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 91 and 122 (71 and 102 respectively in this structure).

Details

Redox score ?
71
PDB code
3bt2
Structure name
structure of urokinase receptor, urokinase and vitronectin complex
Structure deposition date
2007-12-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
91
Residue number B
122
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 91 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 33 and 62 (13 and 42 respectively in this structure).

Details

Redox score ?
68
PDB code
2i9a
Structure name
crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (atf)
Structure deposition date
2006-09-05
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
33
Residue number B
62
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 33 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 62 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 91 and 146 (71 and 126 respectively in this structure).

Details

Redox score ?
67
PDB code
4k24
Structure name
structure of anti-upar fab atn-658 in complex with upar
Structure deposition date
2013-04-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
91
Residue number B
146
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 91 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 146 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 39 and 51 (19 and 31 respectively in this structure).

Details

Redox score ?
67
PDB code
4k24
Structure name
structure of anti-upar fab atn-658 in complex with upar
Structure deposition date
2013-04-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
39
Residue number B
51
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 39 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 122 and 133 (102 and 113 respectively in this structure).

Details

Redox score ?
66
PDB code
2i9a
Structure name
crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (atf)
Structure deposition date
2006-09-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
122
Residue number B
133
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 122 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 51 and 62 (31 and 42 respectively in this structure).

Details

Redox score ?
66
PDB code
3bt2
Structure name
structure of urokinase receptor, urokinase and vitronectin complex
Structure deposition date
2007-12-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
51
Residue number B
62
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 51 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 62 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 33 and 53 (13 and 33 respectively in this structure).

Details

Redox score ?
61
PDB code
2i9a
Structure name
crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (atf)
Structure deposition date
2006-09-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
33
Residue number B
53
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 33 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 53 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 133 and 146 (113 and 126 respectively in this structure).

Details

Redox score ?
61
PDB code
2fd6
Structure name
structure of human urokinase plasminogen activator in complex with urokinase receptor and an anti-upar antibody at 1
Structure deposition date
2005-12-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
133
Residue number B
146
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 133 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 146 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 31 and 51 (11 and 31 respectively in this structure).

Details

Redox score ?
60
PDB code
3bt1
Structure name
structure of urokinase receptor, urokinase and vitronectin complex
Structure deposition date
2007-12-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
31
Residue number B
51
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 31 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 51 and 53 (31 and 33 respectively in this structure).

Details

Redox score ?
60
PDB code
3u73
Structure name
crystal structure of stabilized human upar mutant in complex with atf
Structure deposition date
2011-10-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
51
Residue number B
53
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 51 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 53 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 31 and 62 (11 and 42 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2i9a
Structure name
crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (atf)
Structure deposition date
2006-09-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
31
Residue number B
62
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 31 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 62 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 31 and 53 (11 and 33 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2i9a
Structure name
crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (atf)
Structure deposition date
2006-09-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
31
Residue number B
53
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 31 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 53 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 39 and 62 (19 and 42 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4k24
Structure name
structure of anti-upar fab atn-658 in complex with upar
Structure deposition date
2013-04-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
39
Residue number B
62
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 39 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 62 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 70 and 146 (50 and 126 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1urk
Structure name
solution structure of the amino terminal fragment of urokinase-type plasminogen activator
Structure deposition date
1994-01-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
70
Residue number B
146
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 70 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 146 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Urokinase-type plasminogen activator between cysteines 39 and 53 (19 and 33 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3bt1
Structure name
structure of urokinase receptor, urokinase and vitronectin complex
Structure deposition date
2007-12-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00749
Residue number A
39
Residue number B
53
Peptide name
Urokinase-type plasminogen activator

Ligandability

Cysteine 39 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 53 of Urokinase-type plasminogen activator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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