ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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2'-5'-oligoadenylate synthase 1

Intramolecular
Cysteine 331 and cysteine 332
Cysteine 45 and cysteine 109
Cysteine 176 and cysteine 286 L
Cysteine 177 and cysteine 189
A redox-regulated disulphide may form within 2'-5'-oligoadenylate synthase 1 between cysteines 331 and 332.

Details

Redox score ?
70
PDB code
4rwp
Structure name
crystal structure of porcine oas1 in complex with dsrna
Structure deposition date
2014-12-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
76
Peptide accession
Q29599
Residue number A
331
Residue number B
332
Peptide name
2'-5'-oligoadenylate synthase 1

Ligandability

Cysteine 331 of 2'-5'-oligoadenylate synthase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 332 of 2'-5'-oligoadenylate synthase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 2'-5'-oligoadenylate synthase 1 between cysteines 45 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4ig8
Structure name
structural basis for cytosolic double-stranded rna surveillance by human oas1
Structure deposition date
2012-12-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
60
Peptide accession
P00973
Residue number A
45
Residue number B
109
Peptide name
2'-5'-oligoadenylate synthase 1

Ligandability

Cysteine 45 of 2'-5'-oligoadenylate synthase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of 2'-5'-oligoadenylate synthase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 2'-5'-oligoadenylate synthase 1 between cysteines 176 and 286. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4rwp
Structure name
crystal structure of porcine oas1 in complex with dsrna
Structure deposition date
2014-12-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
66
Peptide accession
Q29599
Residue number A
176
Residue number B
286
Peptide name
2'-5'-oligoadenylate synthase 1

Ligandability

Cysteine 176 of 2'-5'-oligoadenylate synthase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of 2'-5'-oligoadenylate synthase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 2'-5'-oligoadenylate synthase 1 between cysteines 177 and 189. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4ig8
Structure name
structural basis for cytosolic double-stranded rna surveillance by human oas1
Structure deposition date
2012-12-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
84
Peptide accession
P00973
Residue number A
177
Residue number B
189
Peptide name
2'-5'-oligoadenylate synthase 1

Ligandability

Cysteine 177 of 2'-5'-oligoadenylate synthase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of 2'-5'-oligoadenylate synthase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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