Serine protease inhibitor Kazal-type 1
Intramolecular
Cysteine 47 and cysteine 79
Cysteine 32 and cysteine 61
Cysteine 39 and cysteine 58
Cysteine 32 and cysteine 58
Cysteine 58 and cysteine 61
Cysteine 32 and cysteine 39
Cysteine 39 and cysteine 61
7qe8 D 47 D 79
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 1 between cysteines 47 and 79.
Details
Redox score ?
87
PDB code
7qe8
Structure name
human cationic trypsin (try1) complexed with serine protease inhibitor kazal type 1 (spink1)
Structure deposition date
2021-12-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00995
Residue number A
47
Residue number B
79
Peptide name
Serine protease inhibitor Kazal-type 1
Ligandability
Cysteine 47 of Serine protease inhibitor Kazal-type 1
Cysteine 79 of Serine protease inhibitor Kazal-type 1
1cgi I 9 I 38
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 1 between cysteines 32 and 61 (9 and 38 respectively in this structure).
Details
Redox score ?
83
PDB code
1cgi
Structure name
three-dimensional structure of the complexes between bovine chymotrypsinogen*a and two recombinant variants of human pancreatic secretory trypsin inhibitor (kazal-type)
Structure deposition date
1991-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00995
Residue number A
32
Residue number B
61
Peptide name
Serine protease inhibitor Kazal-type 1
Ligandability
Cysteine 32 of Serine protease inhibitor Kazal-type 1
Cysteine 61 of Serine protease inhibitor Kazal-type 1
1hpt A 16 A 35
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 1 between cysteines 39 and 58 (16 and 35 respectively in this structure).
Details
Redox score ?
83
PDB code
1hpt
Structure name
three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (kazal type)
Structure deposition date
1992-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00995
Residue number A
39
Residue number B
58
Peptide name
Serine protease inhibitor Kazal-type 1
Ligandability
Cysteine 39 of Serine protease inhibitor Kazal-type 1
Cysteine 58 of Serine protease inhibitor Kazal-type 1
1hpt A 9 A 35
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 1 between cysteines 32 and 58 (9 and 35 respectively in this structure).
Details
Redox score ?
68
PDB code
1hpt
Structure name
three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (kazal type)
Structure deposition date
1992-03-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00995
Residue number A
32
Residue number B
58
Peptide name
Serine protease inhibitor Kazal-type 1
Ligandability
Cysteine 32 of Serine protease inhibitor Kazal-type 1
Cysteine 58 of Serine protease inhibitor Kazal-type 1
7qe8 D 58 D 61
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 1 between cysteines 58 and 61.
Details
Redox score ?
64
PDB code
7qe8
Structure name
human cationic trypsin (try1) complexed with serine protease inhibitor kazal type 1 (spink1)
Structure deposition date
2021-12-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00995
Residue number A
58
Residue number B
61
Peptide name
Serine protease inhibitor Kazal-type 1
Ligandability
Cysteine 58 of Serine protease inhibitor Kazal-type 1
Cysteine 61 of Serine protease inhibitor Kazal-type 1
1cgj I 9 I 16
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 1 between cysteines 32 and 39 (9 and 16 respectively in this structure).
Details
Redox score ?
61
PDB code
1cgj
Structure name
three-dimensional structure of the complexes between bovine chymotrypsinogen*a and two recombinant variants of human pancreatic secretory trypsin inhibitor (kazal-type)
Structure deposition date
1991-10-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00995
Residue number A
32
Residue number B
39
Peptide name
Serine protease inhibitor Kazal-type 1
Ligandability
Cysteine 32 of Serine protease inhibitor Kazal-type 1
Cysteine 39 of Serine protease inhibitor Kazal-type 1
1cgj I 16 I 38
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 1 between cysteines 39 and 61 (16 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
1cgj
Structure name
three-dimensional structure of the complexes between bovine chymotrypsinogen*a and two recombinant variants of human pancreatic secretory trypsin inhibitor (kazal-type)
Structure deposition date
1991-10-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00995
Residue number A
39
Residue number B
61
Peptide name
Serine protease inhibitor Kazal-type 1
Ligandability
Cysteine 39 of Serine protease inhibitor Kazal-type 1
Cysteine 61 of Serine protease inhibitor Kazal-type 1
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