ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Angiotensinogen

Intermolecular
Cysteine 340 and cysteine 340
Intramolecular
Cysteine 51 and cysteine 171
A redox-regulated disulphide may form between two units of Angiotensinogen at cysteines 340 and 340 (316 and 316 respectively in this structure).

Details

Redox score ?
80
PDB code
2wy1
Structure name
crystal structure of rat angiotensinogen in p321 space group
Structure deposition date
2009-11-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
67
Peptide A name
Angiotensinogen
Peptide B name
Angiotensinogen
Peptide A accession
P01015
Peptide B accession
P01015
Peptide A residue number
340
Peptide B residue number
340

Ligandability

A redox-regulated disulphide may form within Angiotensinogen between cysteines 51 and 171 (18 and 138 respectively in this structure).

Details

Redox score ?
87
PDB code
2wxw
Structure name
crystal structure of human angiotensinogen
Structure deposition date
2009-11-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01019
Residue number A
51
Residue number B
171
Peptide name
Angiotensinogen

Ligandability

Cysteine 51 of Angiotensinogen

Cysteine 171 of Angiotensinogen

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