a tool for identifying drug-targetable redox-active disulphides

GTPase HRas

Intramolecular

Cysteine 80 and cysteine 118

A redox-regulated disulphide may form within GTPase HRas between cysteines 80 and 118 (80 and 97 respectively in this structure).

Details

Redox score ?

nan

PDB code

Structure name

crystal structure of hras in complex with the ras-binding and cysteine-rich domains of craf-kinase

Structure deposition date

2020-07-21

Thiol separation (Å)

4

Half-sphere exposure sum ?

94

Minimum pK_a ?

8

% buried

94

Peptide accession

Residue number A

80

Residue number B

118

Peptide name

GTPase HRas

Ligandability

Cysteine 80 of GTPase HRas

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of GTPase HRas

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 97 has been assigned to correct residue.

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