ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GTPase KRas

Intermolecular
Cysteine 299 of Protein farnesyltransferase subunit beta and cysteine 186
Cysteine 95 of Protein farnesyltransferase subunit beta and cysteine 186
Cysteine 366 of Protein farnesyltransferase subunit beta and cysteine 186
A redox-regulated disulphide may form between cysteine 299 of Protein farnesyltransferase subunit beta and cysteine 186 of GTPase KRas (299 and 8 respectively in this structure).

Details

Redox score ?
76
PDB code
1d8d
Structure name
co-crystal structure of rat protein farnesyltransferase complexed with a k-ras4b peptide substrate and fpp analog at 2
Structure deposition date
1999-10-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
5
% buried
100
Peptide A name
Protein farnesyltransferase subunit beta
Peptide B name
GTPase KRas
Peptide A accession
Q02293
Peptide B accession
P01116
Peptide A residue number
299
Peptide B residue number
186

Ligandability

Cysteine 299 of Protein farnesyltransferase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of GTPase KRas

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 95 of Protein farnesyltransferase subunit beta and cysteine 186 of GTPase KRas (95 and 8 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
1kzo
Structure name
protein farnesyltransferase complexed with farnesylated k-ras4b peptide product and farnesyl diphosphate substrate bound simultaneously
Structure deposition date
2002-02-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
12
% buried
94
Peptide A name
Protein farnesyltransferase subunit beta
Peptide B name
GTPase KRas
Peptide A accession
Q02293
Peptide B accession
P01118
Peptide A residue number
95
Peptide B residue number
186

Ligandability

Cysteine 95 of Protein farnesyltransferase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of GTPase KRas

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 366 of Protein farnesyltransferase subunit beta and cysteine 186 of GTPase KRas (366 and 8 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1d8d
Structure name
co-crystal structure of rat protein farnesyltransferase complexed with a k-ras4b peptide substrate and fpp analog at 2
Structure deposition date
1999-10-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
5
% buried
100
Peptide A name
Protein farnesyltransferase subunit beta
Peptide B name
GTPase KRas
Peptide A accession
Q02293
Peptide B accession
P01116
Peptide A residue number
366
Peptide B residue number
186

Ligandability

Cysteine 366 of Protein farnesyltransferase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of GTPase KRas

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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