Platelet-derived growth factor subunit B
Intermolecular
Cysteine 124 and cysteine 133
Cysteine 124 and cysteine 180
Cysteine 141 and cysteine 124
Cysteine 124 and cysteine 97
Cysteine 124 and cysteine 134
Intramolecular
Cysteine 130 and cysteine 178
Cysteine 134 and cysteine 180
Cysteine 97 and cysteine 141
Cysteine 97 and cysteine 180
Cysteine 97 and cysteine 178
More...Cysteine 134 and cysteine 141
Cysteine 141 and cysteine 178
Cysteine 130 and cysteine 141
Cysteine 97 and cysteine 134
Cysteine 141 and cysteine 180
Cysteine 97 and cysteine 130
Cysteine 133 and cysteine 134
Cysteine 178 and cysteine 180
Cysteine 133 and cysteine 141
Cysteine 97 and cysteine 133
Cysteine 133 and cysteine 180
Cysteine 134 and cysteine 178
Cysteine 130 and cysteine 180
Cysteine 130 and cysteine 134
4qci C 43 D 52
A redox-regulated disulphide may form between two units of Platelet-derived growth factor subunit B at cysteines 124 and 133 (43 and 52 respectively in this structure).
Details
Redox score ?
82
PDB code
4qci
Structure name
pdgf-b blocking antibody bound to pdgf-bb
Structure deposition date
2014-05-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
Platelet-derived growth factor subunit B
Peptide B name
Platelet-derived growth factor subunit B
Peptide A accession
P01127
Peptide B accession
P01127
Peptide A residue number
124
Peptide B residue number
133
Ligandability
Cysteine 124 of Platelet-derived growth factor subunit B
Cysteine 133 of Platelet-derived growth factor subunit B
1pdg A 43 B 99
A redox-regulated disulphide may form between two units of Platelet-derived growth factor subunit B at cysteines 124 and 180 (43 and 99 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
1pdg
Structure name
crystal structure of human platelet-derived growth factor bb
Structure deposition date
1992-07-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide A name
Platelet-derived growth factor subunit B
Peptide B name
Platelet-derived growth factor subunit B
Peptide A accession
P01127
Peptide B accession
P01127
Peptide A residue number
124
Peptide B residue number
180
Ligandability
Cysteine 124 of Platelet-derived growth factor subunit B
Cysteine 180 of Platelet-derived growth factor subunit B
1pdg A 60 B 43
A redox-regulated disulphide may form between two units of Platelet-derived growth factor subunit B at cysteines 141 and 124 (60 and 43 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
1pdg
Structure name
crystal structure of human platelet-derived growth factor bb
Structure deposition date
1992-07-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide A name
Platelet-derived growth factor subunit B
Peptide B name
Platelet-derived growth factor subunit B
Peptide A accession
P01127
Peptide B accession
P01127
Peptide A residue number
141
Peptide B residue number
124
Ligandability
Cysteine 141 of Platelet-derived growth factor subunit B
Cysteine 124 of Platelet-derived growth factor subunit B
4qci C 43 D 16
A redox-regulated disulphide may form between two units of Platelet-derived growth factor subunit B at cysteines 124 and 97 (43 and 16 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
4qci
Structure name
pdgf-b blocking antibody bound to pdgf-bb
Structure deposition date
2014-05-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide A name
Platelet-derived growth factor subunit B
Peptide B name
Platelet-derived growth factor subunit B
Peptide A accession
P01127
Peptide B accession
P01127
Peptide A residue number
124
Peptide B residue number
97
Ligandability
Cysteine 124 of Platelet-derived growth factor subunit B
Cysteine 97 of Platelet-derived growth factor subunit B
3mjg A 43 B 53
A redox-regulated disulphide may form between two units of Platelet-derived growth factor subunit B at cysteines 124 and 134 (43 and 53 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
3mjg
Structure name
the structure of a platelet derived growth factor receptor complex
Structure deposition date
2010-04-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Platelet-derived growth factor subunit B
Peptide B name
Platelet-derived growth factor subunit B
Peptide A accession
P01127
Peptide B accession
P01127
Peptide A residue number
124
Peptide B residue number
134
Ligandability
Cysteine 124 of Platelet-derived growth factor subunit B
Cysteine 134 of Platelet-derived growth factor subunit B
4qci D 49 D 97
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 130 and 178 (49 and 97 respectively in this structure).
Details
Redox score ?
87
PDB code
4qci
Structure name
pdgf-b blocking antibody bound to pdgf-bb
Structure deposition date
2014-05-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
130
Residue number B
178
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 130 of Platelet-derived growth factor subunit B
Cysteine 178 of Platelet-derived growth factor subunit B
1pdg A 53 A 99
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 134 and 180 (53 and 99 respectively in this structure).
Details
Redox score ?
86
PDB code
1pdg
Structure name
crystal structure of human platelet-derived growth factor bb
Structure deposition date
1992-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
134
Residue number B
180
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 134 of Platelet-derived growth factor subunit B
Cysteine 180 of Platelet-derived growth factor subunit B
4qci D 16 D 60
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 97 and 141 (16 and 60 respectively in this structure).
Details
Redox score ?
85
PDB code
4qci
Structure name
pdgf-b blocking antibody bound to pdgf-bb
Structure deposition date
2014-05-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
97
Residue number B
141
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 97 of Platelet-derived growth factor subunit B
Cysteine 141 of Platelet-derived growth factor subunit B
1pdg A 16 A 99
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 97 and 180 (16 and 99 respectively in this structure).
Details
Redox score ?
73
PDB code
1pdg
Structure name
crystal structure of human platelet-derived growth factor bb
Structure deposition date
1992-07-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
97
Residue number B
180
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 97 of Platelet-derived growth factor subunit B
Cysteine 180 of Platelet-derived growth factor subunit B
1pdg B 16 B 97
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 97 and 178 (16 and 97 respectively in this structure).
Details
Redox score ?
71
PDB code
1pdg
Structure name
crystal structure of human platelet-derived growth factor bb
Structure deposition date
1992-07-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
97
Residue number B
178
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 97 of Platelet-derived growth factor subunit B
Cysteine 178 of Platelet-derived growth factor subunit B
4hqx A 53 A 60
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 134 and 141 (53 and 60 respectively in this structure).
Details
Redox score ?
70
PDB code
4hqx
Structure name
crystal structure of human pdgf-bb in complex with a modified nucleotide aptamer (somamer sl4)
Structure deposition date
2012-10-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
134
Residue number B
141
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 134 of Platelet-derived growth factor subunit B
Cysteine 141 of Platelet-derived growth factor subunit B
1pdg B 60 B 97
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 141 and 178 (60 and 97 respectively in this structure).
Details
Redox score ?
69
PDB code
1pdg
Structure name
crystal structure of human platelet-derived growth factor bb
Structure deposition date
1992-07-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
141
Residue number B
178
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 141 of Platelet-derived growth factor subunit B
Cysteine 178 of Platelet-derived growth factor subunit B
3mjg A 49 A 60
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 130 and 141 (49 and 60 respectively in this structure).
Details
Redox score ?
67
PDB code
3mjg
Structure name
the structure of a platelet derived growth factor receptor complex
Structure deposition date
2010-04-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
130
Residue number B
141
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 130 of Platelet-derived growth factor subunit B
Cysteine 141 of Platelet-derived growth factor subunit B
3mjg A 16 A 53
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 97 and 134 (16 and 53 respectively in this structure).
Details
Redox score ?
66
PDB code
3mjg
Structure name
the structure of a platelet derived growth factor receptor complex
Structure deposition date
2010-04-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
97
Residue number B
134
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 97 of Platelet-derived growth factor subunit B
Cysteine 134 of Platelet-derived growth factor subunit B
4qci D 60 D 99
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 141 and 180 (60 and 99 respectively in this structure).
Details
Redox score ?
66
PDB code
4qci
Structure name
pdgf-b blocking antibody bound to pdgf-bb
Structure deposition date
2014-05-12
Thiol separation (Å)
6
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
141
Residue number B
180
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 141 of Platelet-derived growth factor subunit B
Cysteine 180 of Platelet-derived growth factor subunit B
3mjg B 16 B 49
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 97 and 130 (16 and 49 respectively in this structure).
Details
Redox score ?
63
PDB code
3mjg
Structure name
the structure of a platelet derived growth factor receptor complex
Structure deposition date
2010-04-12
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
97
Residue number B
130
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 97 of Platelet-derived growth factor subunit B
Cysteine 130 of Platelet-derived growth factor subunit B
4qci C 52 C 53
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 133 and 134 (52 and 53 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
4qci
Structure name
pdgf-b blocking antibody bound to pdgf-bb
Structure deposition date
2014-05-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
133
Residue number B
134
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 133 of Platelet-derived growth factor subunit B
Cysteine 134 of Platelet-derived growth factor subunit B
1pdg A 97 A 99
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 178 and 180 (97 and 99 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
1pdg
Structure name
crystal structure of human platelet-derived growth factor bb
Structure deposition date
1992-07-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
178
Residue number B
180
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 178 of Platelet-derived growth factor subunit B
Cysteine 180 of Platelet-derived growth factor subunit B
1pdg C 52 C 60
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 133 and 141 (52 and 60 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
1pdg
Structure name
crystal structure of human platelet-derived growth factor bb
Structure deposition date
1992-07-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
nan
Peptide accession
P01127
Residue number A
133
Residue number B
141
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 133 of Platelet-derived growth factor subunit B
Cysteine 141 of Platelet-derived growth factor subunit B
4hqx A 16 A 52
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 97 and 133 (16 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4hqx
Structure name
crystal structure of human pdgf-bb in complex with a modified nucleotide aptamer (somamer sl4)
Structure deposition date
2012-10-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
nan
Peptide accession
P01127
Residue number A
97
Residue number B
133
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 97 of Platelet-derived growth factor subunit B
Cysteine 133 of Platelet-derived growth factor subunit B
3mjg A 52 A 99
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 133 and 180 (52 and 99 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3mjg
Structure name
the structure of a platelet derived growth factor receptor complex
Structure deposition date
2010-04-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
133
Residue number B
180
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 133 of Platelet-derived growth factor subunit B
Cysteine 180 of Platelet-derived growth factor subunit B
3mjg B 53 B 97
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 134 and 178 (53 and 97 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3mjg
Structure name
the structure of a platelet derived growth factor receptor complex
Structure deposition date
2010-04-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
134
Residue number B
178
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 134 of Platelet-derived growth factor subunit B
Cysteine 178 of Platelet-derived growth factor subunit B
3mjg A 49 A 99
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 130 and 180 (49 and 99 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
3mjg
Structure name
the structure of a platelet derived growth factor receptor complex
Structure deposition date
2010-04-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
130
Residue number B
180
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 130 of Platelet-derived growth factor subunit B
Cysteine 180 of Platelet-derived growth factor subunit B
3mjg A 49 A 53
A redox-regulated disulphide may form within Platelet-derived growth factor subunit B between cysteines 130 and 134 (49 and 53 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
3mjg
Structure name
the structure of a platelet derived growth factor receptor complex
Structure deposition date
2010-04-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01127
Residue number A
130
Residue number B
134
Peptide name
Platelet-derived growth factor subunit B
Ligandability
Cysteine 130 of Platelet-derived growth factor subunit B
Cysteine 134 of Platelet-derived growth factor subunit B
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