Low-density lipoprotein receptor
Intramolecular
Cysteine 204 and cysteine 222
Cysteine 34 and cysteine 52
Cysteine 284 and cysteine 302
Cysteine 243 and cysteine 261
Cysteine 276 and cysteine 289
Cysteine 255 and cysteine 270
Cysteine 216 and cysteine 231
Cysteine 167 and cysteine 184
Cysteine 68 and cysteine 82
Cysteine 197 and cysteine 209
More...Cysteine 236 and cysteine 248
Cysteine 325 and cysteine 338
Cysteine 109 and cysteine 121
Cysteine 296 and cysteine 313
Cysteine 358 and cysteine 368
Cysteine 116 and cysteine 134
Cysteine 155 and cysteine 173
Cysteine 364 and cysteine 377
Cysteine 27 and cysteine 39
Cysteine 89 and cysteine 104
Cysteine 677 and cysteine 696
Cysteine 46 and cysteine 63
Cysteine 340 and cysteine 352
Cysteine 379 and cysteine 392
Cysteine 148 and cysteine 160
Cysteine 75 and cysteine 95
Cysteine 128 and cysteine 143
Cysteine 318 and cysteine 329
Cysteine 667 and cysteine 681
Cysteine 698 and cysteine 711
Cysteine 677 and cysteine 681
Cysteine 325 and cysteine 329
Cysteine 368 and cysteine 377
Cysteine 377 and cysteine 392
Cysteine 329 and cysteine 338
Cysteine 364 and cysteine 368
Cysteine 318 and cysteine 325
Cysteine 109 and cysteine 116
Cysteine 681 and cysteine 696
Cysteine 364 and cysteine 392
1ajj A 12 A 30
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 204 and 222 (12 and 30 respectively in this structure).
Details
Redox score ?
89
PDB code
1ajj
Structure name
ldl receptor ligand-binding module 5, calcium-coordinating
Structure deposition date
1997-05-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
204
Residue number B
222
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 204 of Low-density lipoprotein receptor
Cysteine 222 of Low-density lipoprotein receptor
1ldl A 13 A 31
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 34 and 52 (13 and 31 respectively in this structure).
Details
Redox score ?
89
PDB code
1ldl
Structure name
three-dimensional structure of a cysteine-rich repeat from the low- density lipoprotein receptor
Structure deposition date
1995-03-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
34
Residue number B
52
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 34 of Low-density lipoprotein receptor
Cysteine 52 of Low-density lipoprotein receptor
3p5c L 263 L 281
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 284 and 302 (263 and 281 respectively in this structure).
Details
Redox score ?
89
PDB code
3p5c
Structure name
the structure of the ldlr/pcsk9 complex reveals the receptor in an extended conformation
Structure deposition date
2010-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59FQ1
Residue number A
284
Residue number B
302
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 284 of Low-density lipoprotein receptor
Cysteine 302 of Low-density lipoprotein receptor
1n7d A 222 A 240
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 243 and 261 (222 and 240 respectively in this structure).
Details
Redox score ?
89
PDB code
1n7d
Structure name
extracellular domain of the ldl receptor
Structure deposition date
2002-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
243
Residue number B
261
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 243 of Low-density lipoprotein receptor
Cysteine 261 of Low-density lipoprotein receptor
3m0c C 255 C 268
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 276 and 289 (255 and 268 respectively in this structure).
Details
Redox score ?
89
PDB code
3m0c
Structure name
the x-ray crystal structure of pcsk9 in complex with the ldl receptor
Structure deposition date
2010-03-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
276
Residue number B
289
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 276 of Low-density lipoprotein receptor
Cysteine 289 of Low-density lipoprotein receptor
1n7d A 234 A 249
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 255 and 270 (234 and 249 respectively in this structure).
Details
Redox score ?
88
PDB code
1n7d
Structure name
extracellular domain of the ldl receptor
Structure deposition date
2002-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
35
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
255
Residue number B
270
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 255 of Low-density lipoprotein receptor
Cysteine 270 of Low-density lipoprotein receptor
1ajj A 24 A 39
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 216 and 231 (24 and 39 respectively in this structure).
Details
Redox score ?
88
PDB code
1ajj
Structure name
ldl receptor ligand-binding module 5, calcium-coordinating
Structure deposition date
1997-05-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
35
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
216
Residue number B
231
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 216 of Low-density lipoprotein receptor
Cysteine 231 of Low-density lipoprotein receptor
2fcw B 146 B 163
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 167 and 184 (146 and 163 respectively in this structure).
Details
Redox score ?
88
PDB code
2fcw
Structure name
structure of a complex between the pair of the ldl receptor ligand- binding modules 3-4 and the receptor associated protein (rap)
Structure deposition date
2005-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
167
Residue number B
184
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 167 of Low-density lipoprotein receptor
Cysteine 184 of Low-density lipoprotein receptor
1n7d A 47 A 61
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 68 and 82 (47 and 61 respectively in this structure).
Details
Redox score ?
88
PDB code
1n7d
Structure name
extracellular domain of the ldl receptor
Structure deposition date
2002-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
37
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
68
Residue number B
82
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 68 of Low-density lipoprotein receptor
Cysteine 82 of Low-density lipoprotein receptor
1ajj A 5 A 17
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 197 and 209 (5 and 17 respectively in this structure).
Details
Redox score ?
88
PDB code
1ajj
Structure name
ldl receptor ligand-binding module 5, calcium-coordinating
Structure deposition date
1997-05-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
197
Residue number B
209
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 197 of Low-density lipoprotein receptor
Cysteine 209 of Low-density lipoprotein receptor
1n7d A 215 A 227
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 236 and 248 (215 and 227 respectively in this structure).
Details
Redox score ?
87
PDB code
1n7d
Structure name
extracellular domain of the ldl receptor
Structure deposition date
2002-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
236
Residue number B
248
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 236 of Low-density lipoprotein receptor
Cysteine 248 of Low-density lipoprotein receptor
3p5c L 304 L 317
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 325 and 338 (304 and 317 respectively in this structure).
Details
Redox score ?
87
PDB code
3p5c
Structure name
the structure of the ldlr/pcsk9 complex reveals the receptor in an extended conformation
Structure deposition date
2010-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59FQ1
Residue number A
325
Residue number B
338
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 325 of Low-density lipoprotein receptor
Cysteine 338 of Low-density lipoprotein receptor
5oy9 D 88 D 100
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 109 and 121 (88 and 100 respectively in this structure).
Details
Redox score ?
87
PDB code
5oy9
Structure name
vsv g cr3
Structure deposition date
2017-09-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
109
Residue number B
121
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 109 of Low-density lipoprotein receptor
Cysteine 121 of Low-density lipoprotein receptor
1n7d A 275 A 292
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 296 and 313 (275 and 292 respectively in this structure).
Details
Redox score ?
87
PDB code
1n7d
Structure name
extracellular domain of the ldl receptor
Structure deposition date
2002-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
296
Residue number B
313
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 296 of Low-density lipoprotein receptor
Cysteine 313 of Low-density lipoprotein receptor
3m0c C 337 C 347
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 358 and 368 (337 and 347 respectively in this structure).
Details
Redox score ?
87
PDB code
3m0c
Structure name
the x-ray crystal structure of pcsk9 in complex with the ldl receptor
Structure deposition date
2010-03-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
358
Residue number B
368
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 358 of Low-density lipoprotein receptor
Cysteine 368 of Low-density lipoprotein receptor
5oy9 D 95 D 113
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 116 and 134 (95 and 113 respectively in this structure).
Details
Redox score ?
87
PDB code
5oy9
Structure name
vsv g cr3
Structure deposition date
2017-09-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
116
Residue number B
134
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 116 of Low-density lipoprotein receptor
Cysteine 134 of Low-density lipoprotein receptor
2fcw B 134 B 152
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 155 and 173 (134 and 152 respectively in this structure).
Details
Redox score ?
86
PDB code
2fcw
Structure name
structure of a complex between the pair of the ldl receptor ligand- binding modules 3-4 and the receptor associated protein (rap)
Structure deposition date
2005-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
155
Residue number B
173
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 155 of Low-density lipoprotein receptor
Cysteine 173 of Low-density lipoprotein receptor
1n7d A 343 A 356
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 364 and 377 (343 and 356 respectively in this structure).
Details
Redox score ?
86
PDB code
1n7d
Structure name
extracellular domain of the ldl receptor
Structure deposition date
2002-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
364
Residue number B
377
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 364 of Low-density lipoprotein receptor
Cysteine 377 of Low-density lipoprotein receptor
1f5y A 8 A 20
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 27 and 39 (8 and 20 respectively in this structure).
Details
Redox score ?
86
PDB code
1f5y
Structure name
nmr structure of a concatemer of the first and second ligand-binding modules of the human ldl receptor
Structure deposition date
2000-06-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
27
Residue number B
39
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 27 of Low-density lipoprotein receptor
Cysteine 39 of Low-density lipoprotein receptor
1n7d A 68 A 83
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 89 and 104 (68 and 83 respectively in this structure).
Details
Redox score ?
86
PDB code
1n7d
Structure name
extracellular domain of the ldl receptor
Structure deposition date
2002-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
89
Residue number B
104
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 89 of Low-density lipoprotein receptor
Cysteine 104 of Low-density lipoprotein receptor
1n7d A 656 A 675
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 677 and 696 (656 and 675 respectively in this structure).
Details
Redox score ?
86
PDB code
1n7d
Structure name
extracellular domain of the ldl receptor
Structure deposition date
2002-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
677
Residue number B
696
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 677 of Low-density lipoprotein receptor
Cysteine 696 of Low-density lipoprotein receptor
1ldl A 25 A 42
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 46 and 63 (25 and 42 respectively in this structure).
Details
Redox score ?
86
PDB code
1ldl
Structure name
three-dimensional structure of a cysteine-rich repeat from the low- density lipoprotein receptor
Structure deposition date
1995-03-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
46
Residue number B
63
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 46 of Low-density lipoprotein receptor
Cysteine 63 of Low-density lipoprotein receptor
1n7d A 319 A 331
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 340 and 352 (319 and 331 respectively in this structure).
Details
Redox score ?
85
PDB code
1n7d
Structure name
extracellular domain of the ldl receptor
Structure deposition date
2002-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
340
Residue number B
352
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 340 of Low-density lipoprotein receptor
Cysteine 352 of Low-density lipoprotein receptor
1n7d A 358 A 371
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 379 and 392 (358 and 371 respectively in this structure).
Details
Redox score ?
85
PDB code
1n7d
Structure name
extracellular domain of the ldl receptor
Structure deposition date
2002-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
379
Residue number B
392
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 379 of Low-density lipoprotein receptor
Cysteine 392 of Low-density lipoprotein receptor
2fcw B 127 B 139
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 148 and 160 (127 and 139 respectively in this structure).
Details
Redox score ?
85
PDB code
2fcw
Structure name
structure of a complex between the pair of the ldl receptor ligand- binding modules 3-4 and the receptor associated protein (rap)
Structure deposition date
2005-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
148
Residue number B
160
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 148 of Low-density lipoprotein receptor
Cysteine 160 of Low-density lipoprotein receptor
5oyl D 54 D 74
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 75 and 95 (54 and 74 respectively in this structure).
Details
Redox score ?
84
PDB code
5oyl
Structure name
vsv g cr2
Structure deposition date
2017-09-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
75
Residue number B
95
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 75 of Low-density lipoprotein receptor
Cysteine 95 of Low-density lipoprotein receptor
2fcw B 107 B 122
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 128 and 143 (107 and 122 respectively in this structure).
Details
Redox score ?
83
PDB code
2fcw
Structure name
structure of a complex between the pair of the ldl receptor ligand- binding modules 3-4 and the receptor associated protein (rap)
Structure deposition date
2005-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
128
Residue number B
143
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 128 of Low-density lipoprotein receptor
Cysteine 143 of Low-density lipoprotein receptor
3p5c L 297 L 308
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 318 and 329 (297 and 308 respectively in this structure).
Details
Redox score ?
83
PDB code
3p5c
Structure name
the structure of the ldlr/pcsk9 complex reveals the receptor in an extended conformation
Structure deposition date
2010-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59FQ1
Residue number A
318
Residue number B
329
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 318 of Low-density lipoprotein receptor
Cysteine 329 of Low-density lipoprotein receptor
3p5c L 646 L 660
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 667 and 681 (646 and 660 respectively in this structure).
Details
Redox score ?
82
PDB code
3p5c
Structure name
the structure of the ldlr/pcsk9 complex reveals the receptor in an extended conformation
Structure deposition date
2010-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59FQ1
Residue number A
667
Residue number B
681
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 667 of Low-density lipoprotein receptor
Cysteine 681 of Low-density lipoprotein receptor
3p5c L 677 L 690
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 698 and 711 (677 and 690 respectively in this structure).
Details
Redox score ?
80
PDB code
3p5c
Structure name
the structure of the ldlr/pcsk9 complex reveals the receptor in an extended conformation
Structure deposition date
2010-10-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
4
Peptide accession
Q59FQ1
Residue number A
698
Residue number B
711
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 698 of Low-density lipoprotein receptor
Cysteine 711 of Low-density lipoprotein receptor
1ijq A 656 A 660
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 677 and 681 (656 and 660 respectively in this structure).
Details
Redox score ?
77
PDB code
1ijq
Structure name
crystal structure of the ldl receptor ywtd-egf domain pair
Structure deposition date
2001-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
nan
Peptide accession
P01130
Residue number A
677
Residue number B
681
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 677 of Low-density lipoprotein receptor
Cysteine 681 of Low-density lipoprotein receptor
3p5b L 304 L 308
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 325 and 329 (304 and 308 respectively in this structure).
Details
Redox score ?
75
PDB code
3p5b
Structure name
the structure of the ldlr/pcsk9 complex reveals the receptor in an extended conformation
Structure deposition date
2010-10-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59FQ1
Residue number A
325
Residue number B
329
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 325 of Low-density lipoprotein receptor
Cysteine 329 of Low-density lipoprotein receptor
3p5c L 347 L 356
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 368 and 377 (347 and 356 respectively in this structure).
Details
Redox score ?
72
PDB code
3p5c
Structure name
the structure of the ldlr/pcsk9 complex reveals the receptor in an extended conformation
Structure deposition date
2010-10-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
nan
Peptide accession
Q59FQ1
Residue number A
368
Residue number B
377
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 368 of Low-density lipoprotein receptor
Cysteine 377 of Low-density lipoprotein receptor
3m0c C 356 C 371
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 377 and 392 (356 and 371 respectively in this structure).
Details
Redox score ?
69
PDB code
3m0c
Structure name
the x-ray crystal structure of pcsk9 in complex with the ldl receptor
Structure deposition date
2010-03-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
377
Residue number B
392
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 377 of Low-density lipoprotein receptor
Cysteine 392 of Low-density lipoprotein receptor
3p5b L 308 L 317
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 329 and 338 (308 and 317 respectively in this structure).
Details
Redox score ?
65
PDB code
3p5b
Structure name
the structure of the ldlr/pcsk9 complex reveals the receptor in an extended conformation
Structure deposition date
2010-10-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q59FQ1
Residue number A
329
Residue number B
338
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 329 of Low-density lipoprotein receptor
Cysteine 338 of Low-density lipoprotein receptor
1n7d A 343 A 347
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 364 and 368 (343 and 347 respectively in this structure).
Details
Redox score ?
63
PDB code
1n7d
Structure name
extracellular domain of the ldl receptor
Structure deposition date
2002-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
364
Residue number B
368
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 364 of Low-density lipoprotein receptor
Cysteine 368 of Low-density lipoprotein receptor
3gcw E 297 E 304
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 318 and 325 (297 and 304 respectively in this structure).
Details
Redox score ?
62
PDB code
3gcw
Structure name
pcsk9:egfa(h306y)
Structure deposition date
2009-02-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
318
Residue number B
325
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 318 of Low-density lipoprotein receptor
Cysteine 325 of Low-density lipoprotein receptor
1n7d A 88 A 95
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 109 and 116 (88 and 95 respectively in this structure).
Details
Redox score ?
62
PDB code
1n7d
Structure name
extracellular domain of the ldl receptor
Structure deposition date
2002-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
109
Residue number B
116
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 109 of Low-density lipoprotein receptor
Cysteine 116 of Low-density lipoprotein receptor
1ijq B 660 B 675
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 681 and 696 (660 and 675 respectively in this structure).
Details
Redox score ?
62
PDB code
1ijq
Structure name
crystal structure of the ldl receptor ywtd-egf domain pair
Structure deposition date
2001-04-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
nan
Peptide accession
P01130
Residue number A
681
Residue number B
696
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 681 of Low-density lipoprotein receptor
Cysteine 696 of Low-density lipoprotein receptor
3m0c C 343 C 371
A redox-regulated disulphide may form within Low-density lipoprotein receptor between cysteines 364 and 392 (343 and 371 respectively in this structure).
Details
Redox score ?
60
PDB code
3m0c
Structure name
the x-ray crystal structure of pcsk9 in complex with the ldl receptor
Structure deposition date
2010-03-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01130
Residue number A
364
Residue number B
392
Peptide name
Low-density lipoprotein receptor
Ligandability
Cysteine 364 of Low-density lipoprotein receptor
Cysteine 392 of Low-density lipoprotein receptor
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