ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Natriuretic peptides A

Intramolecular
Cysteine 129 and cysteine 23
Cysteine 130 and cysteine 146
A redox-regulated disulphide may form within Natriuretic peptides A between cysteines 129 and 23 (7 and 23 respectively in this structure).

Details

Redox score ?
89
PDB code
7brl
Structure name
atrial natriuretic peptide receptor complexed with deletion mutant of rat atrial natriuretic peptide[4-17,23]
Structure deposition date
2020-03-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01161
Residue number A
129
Residue number B
23
Peptide name
Natriuretic peptides A

Ligandability

Cysteine 129 of Natriuretic peptides A

Cysteine 23 of Natriuretic peptides A

Cysteine 23 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Natriuretic peptides A between cysteines 130 and 146 (7 and 23 respectively in this structure).

Details

Redox score ?
87
PDB code
7brk
Structure name
atrial natriuretic peptide receptor complexed with deletion mutant of human atrial natriuretic peptide[5-27]
Structure deposition date
2020-03-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01160
Residue number A
130
Residue number B
146
Peptide name
Natriuretic peptides A

Ligandability

Cysteine 130 of Natriuretic peptides A

Cysteine 146 of Natriuretic peptides A

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