ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Vasopressin-neurophysin 2-copeptin

Intermolecular
Cysteine 110 and cysteine 110
Cysteine 110 and cysteine 105
Intramolecular
Cysteine 20 and cysteine 25
Cysteine 41 and cysteine 85
Cysteine 98 and cysteine 116
Cysteine 92 and cysteine 116
Cysteine 52 and cysteine 75
Cysteine 92 and cysteine 104
Cysteine 59 and cysteine 65
Cysteine 44 and cysteine 58
More...
Cysteine 44 and cysteine 75
Cysteine 92 and cysteine 98
Cysteine 44 and cysteine 52
Cysteine 59 and cysteine 105
Cysteine 65 and cysteine 105
Cysteine 104 and cysteine 116
Cysteine 65 and cysteine 110
Cysteine 59 and cysteine 110
Cysteine 58 and cysteine 75
Cysteine 98 and cysteine 104
Cysteine 41 and cysteine 52
Cysteine 52 and cysteine 58
Cysteine 105 and cysteine 116
Cysteine 41 and cysteine 75
Cysteine 104 and cysteine 105
Cysteine 92 and cysteine 105
Cysteine 44 and cysteine 59
Cysteine 58 and cysteine 59
Cysteine 52 and cysteine 85
Cysteine 41 and cysteine 44
Cysteine 59 and cysteine 75
Cysteine 75 and cysteine 85
Cysteine 92 and cysteine 110
Cysteine 65 and cysteine 116
Cysteine 98 and cysteine 105
Cysteine 104 and cysteine 110
Cysteine 110 and cysteine 116
Cysteine 44 and cysteine 65
Cysteine 58 and cysteine 65
Cysteine 52 and cysteine 59
A redox-regulated disulphide may form between two units of Vasopressin-neurophysin 2-copeptin at cysteines 110 and 110 (79 and 79 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide A name
Vasopressin-neurophysin 2-copeptin
Peptide B name
Vasopressin-neurophysin 2-copeptin
Peptide A accession
P01180
Peptide B accession
P01180
Peptide A residue number
110
Peptide B residue number
110

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Vasopressin-neurophysin 2-copeptin at cysteines 110 and 105 (79 and 74 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
97
Minimum pKa ?
nan
% buried
nan
Peptide A name
Vasopressin-neurophysin 2-copeptin
Peptide B name
Vasopressin-neurophysin 2-copeptin
Peptide A accession
P01180
Peptide B accession
P01180
Peptide A residue number
110
Peptide B residue number
105

Ligandability

Cysteine 110 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 20 and 25 (1 and 6 respectively in this structure).

Details

Redox score ?
89
PDB code
7kh0
Structure name
cryo-em structure of the human arginine vasopressin avp-vasopressin receptor v2r-gs signaling complex
Structure deposition date
2020-10-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01185
Residue number A
20
Residue number B
25
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 20 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 25 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 41 and 85 (10 and 54 respectively in this structure).

Details

Redox score ?
88
PDB code
1jk6
Structure name
uncomplexed des 1-6 bovine neurophysin
Structure deposition date
2001-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
41
Residue number B
85
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 41 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 85 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 98 and 116 (67 and 85 respectively in this structure).

Details

Redox score ?
84
PDB code
1jk6
Structure name
uncomplexed des 1-6 bovine neurophysin
Structure deposition date
2001-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
98
Residue number B
116
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 98 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 116 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 92 and 116 (61 and 85 respectively in this structure).

Details

Redox score ?
84
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
92
Residue number B
116
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 92 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 116 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 52 and 75 (21 and 44 respectively in this structure).

Details

Redox score ?
83
PDB code
1jk6
Structure name
uncomplexed des 1-6 bovine neurophysin
Structure deposition date
2001-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
52
Residue number B
75
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 52 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 92 and 104 (61 and 73 respectively in this structure).

Details

Redox score ?
82
PDB code
1jk6
Structure name
uncomplexed des 1-6 bovine neurophysin
Structure deposition date
2001-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
92
Residue number B
104
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 92 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 59 and 65 (28 and 34 respectively in this structure).

Details

Redox score ?
80
PDB code
1jk4
Structure name
des 1-6 bovine neurophysin ii complex with vasopressin
Structure deposition date
2001-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
59
Residue number B
65
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 59 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 44 and 58 (13 and 27 respectively in this structure).

Details

Redox score ?
78
PDB code
2bn2
Structure name
crystal structure of bovine neurophysin ii complexed with the vasopressin analogue phe-tyr amide
Structure deposition date
1998-12-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
44
Residue number B
58
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 44 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 44 and 75 (13 and 44 respectively in this structure).

Details

Redox score ?
77
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
44
Residue number B
75
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 44 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 92 and 98 (61 and 67 respectively in this structure).

Details

Redox score ?
76
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
92
Residue number B
98
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 92 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 44 and 52 (13 and 21 respectively in this structure).

Details

Redox score ?
73
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
44
Residue number B
52
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 44 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 59 and 105 (28 and 74 respectively in this structure).

Details

Redox score ?
73
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
101
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
59
Residue number B
105
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 59 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 65 and 105 (34 and 74 respectively in this structure).

Details

Redox score ?
71
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
102
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
65
Residue number B
105
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 65 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 104 and 116 (73 and 85 respectively in this structure).

Details

Redox score ?
67
PDB code
2bn2
Structure name
crystal structure of bovine neurophysin ii complexed with the vasopressin analogue phe-tyr amide
Structure deposition date
1998-12-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
104
Residue number B
116
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 104 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 116 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 65 and 110 (34 and 79 respectively in this structure).

Details

Redox score ?
66
PDB code
1jk6
Structure name
uncomplexed des 1-6 bovine neurophysin
Structure deposition date
2001-07-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
101
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
65
Residue number B
110
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 65 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 59 and 110 (28 and 79 respectively in this structure).

Details

Redox score ?
66
PDB code
1jk6
Structure name
uncomplexed des 1-6 bovine neurophysin
Structure deposition date
2001-07-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
59
Residue number B
110
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 59 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 58 and 75 (27 and 44 respectively in this structure).

Details

Redox score ?
65
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
58
Residue number B
75
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 58 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 98 and 104 (67 and 73 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
98
Residue number B
104
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 98 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 41 and 52 (10 and 21 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
1jk4
Structure name
des 1-6 bovine neurophysin ii complex with vasopressin
Structure deposition date
2001-07-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
41
Residue number B
52
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 41 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 52 and 58 (21 and 27 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
104
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
52
Residue number B
58
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 52 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 105 and 116 (74 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2bn2
Structure name
crystal structure of bovine neurophysin ii complexed with the vasopressin analogue phe-tyr amide
Structure deposition date
1998-12-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
105
Residue number B
116
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 105 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 116 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 41 and 75 (10 and 44 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
41
Residue number B
75
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 41 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 104 and 105 (73 and 74 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2bn2
Structure name
crystal structure of bovine neurophysin ii complexed with the vasopressin analogue phe-tyr amide
Structure deposition date
1998-12-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
104
Residue number B
105
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 104 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 92 and 105 (61 and 74 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
92
Residue number B
105
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 92 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 44 and 59 (13 and 28 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
44
Residue number B
59
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 44 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 59 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 58 and 59 (27 and 28 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2bn2
Structure name
crystal structure of bovine neurophysin ii complexed with the vasopressin analogue phe-tyr amide
Structure deposition date
1998-12-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
103
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
58
Residue number B
59
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 58 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 59 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 52 and 85 (21 and 54 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
52
Residue number B
85
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 52 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 85 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 41 and 44 (10 and 13 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2bn2
Structure name
crystal structure of bovine neurophysin ii complexed with the vasopressin analogue phe-tyr amide
Structure deposition date
1998-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
41
Residue number B
44
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 41 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 44 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 59 and 75 (28 and 44 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2bn2
Structure name
crystal structure of bovine neurophysin ii complexed with the vasopressin analogue phe-tyr amide
Structure deposition date
1998-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
59
Residue number B
75
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 59 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 75 and 85 (44 and 54 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
75
Residue number B
85
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 75 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 85 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 92 and 110 (61 and 79 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1jk6
Structure name
uncomplexed des 1-6 bovine neurophysin
Structure deposition date
2001-07-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
92
Residue number B
110
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 92 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 65 and 116 (34 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2bn2
Structure name
crystal structure of bovine neurophysin ii complexed with the vasopressin analogue phe-tyr amide
Structure deposition date
1998-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
65
Residue number B
116
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 65 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 116 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 98 and 105 (67 and 74 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2bn2
Structure name
crystal structure of bovine neurophysin ii complexed with the vasopressin analogue phe-tyr amide
Structure deposition date
1998-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
98
Residue number B
105
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 98 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 104 and 110 (73 and 79 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
104
Residue number B
110
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 104 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 110 and 116 (79 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2bn2
Structure name
crystal structure of bovine neurophysin ii complexed with the vasopressin analogue phe-tyr amide
Structure deposition date
1998-12-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
110
Residue number B
116
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 110 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 116 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 44 and 65 (13 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2bn2
Structure name
crystal structure of bovine neurophysin ii complexed with the vasopressin analogue phe-tyr amide
Structure deposition date
1998-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
44
Residue number B
65
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 44 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 58 and 65 (27 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1npo
Structure name
bovine neurophysin ii complex with oxytocin
Structure deposition date
1996-02-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
106
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
58
Residue number B
65
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 58 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasopressin-neurophysin 2-copeptin between cysteines 52 and 59 (21 and 28 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2bn2
Structure name
crystal structure of bovine neurophysin ii complexed with the vasopressin analogue phe-tyr amide
Structure deposition date
1998-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01180
Residue number A
52
Residue number B
59
Peptide name
Vasopressin-neurophysin 2-copeptin

Ligandability

Cysteine 52 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 59 of Vasopressin-neurophysin 2-copeptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: