Thyrotropin subunit beta
Intermolecular
Cysteine 31 of Glycoprotein hormones alpha chain and cysteine 51
Cysteine 31 of Glycoprotein hormones alpha chain and cysteine 22
Cysteine 31 of Glycoprotein hormones alpha chain and cysteine 105
Cysteine 31 of Glycoprotein hormones alpha chain and cysteine 72
Cysteine 55 of Glycoprotein hormones alpha chain and cysteine 22
Cysteine 111 of Glycoprotein hormones alpha chain and cysteine 108
Cysteine 111 of Glycoprotein hormones alpha chain and cysteine 115
Cysteine 55 of Glycoprotein hormones alpha chain and cysteine 72
Cysteine 55 of Glycoprotein hormones alpha chain and cysteine 105
Cysteine 55 of Glycoprotein hormones alpha chain and cysteine 51
More...Cysteine 111 of Glycoprotein hormones alpha chain and cysteine 51
Cysteine 83 of Glycoprotein hormones alpha chain and cysteine 51
Cysteine 111 of Glycoprotein hormones alpha chain and cysteine 72
Cysteine 83 of Glycoprotein hormones alpha chain and cysteine 72
Intramolecular
Cysteine 36 and cysteine 87
Cysteine 39 and cysteine 125
Cysteine 47 and cysteine 103
Cysteine 22 and cysteine 72
Cysteine 51 and cysteine 105
Cysteine 108 and cysteine 115
Cysteine 22 and cysteine 103
Cysteine 22 and cysteine 105
Cysteine 22 and cysteine 51
Cysteine 22 and cysteine 47
Cysteine 72 and cysteine 103
Cysteine 51 and cysteine 72
Cysteine 47 and cysteine 72
Cysteine 72 and cysteine 105
Cysteine 103 and cysteine 105
Cysteine 51 and cysteine 103
Cysteine 47 and cysteine 105
Cysteine 47 and cysteine 51
7xw5 X 7 Y 51
A redox-regulated disulphide may form between cysteine 31 of Glycoprotein hormones alpha chain and cysteine 51 of Thyrotropin subunit beta (7 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
7xw5
Structure name
tshr-thyroid stimulating hormone-gs-ml109 complex
Structure deposition date
2022-05-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
31
Peptide B residue number
51
Ligandability
Cysteine 31 of Glycoprotein hormones alpha chain
Cysteine 51 of Thyrotropin subunit beta
7xw5 X 7 Y 22
A redox-regulated disulphide may form between cysteine 31 of Glycoprotein hormones alpha chain and cysteine 22 of Thyrotropin subunit beta (7 and 22 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7xw5
Structure name
tshr-thyroid stimulating hormone-gs-ml109 complex
Structure deposition date
2022-05-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
31
Peptide B residue number
22
Ligandability
Cysteine 31 of Glycoprotein hormones alpha chain
Cysteine 22 of Thyrotropin subunit beta
7xw5 X 7 Y 105
A redox-regulated disulphide may form between cysteine 31 of Glycoprotein hormones alpha chain and cysteine 105 of Thyrotropin subunit beta (7 and 105 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7xw5
Structure name
tshr-thyroid stimulating hormone-gs-ml109 complex
Structure deposition date
2022-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
31
Peptide B residue number
105
Ligandability
Cysteine 31 of Glycoprotein hormones alpha chain
Cysteine 105 of Thyrotropin subunit beta
7xw5 X 7 Y 72
A redox-regulated disulphide may form between cysteine 31 of Glycoprotein hormones alpha chain and cysteine 72 of Thyrotropin subunit beta (7 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7xw5
Structure name
tshr-thyroid stimulating hormone-gs-ml109 complex
Structure deposition date
2022-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
31
Peptide B residue number
72
Ligandability
Cysteine 31 of Glycoprotein hormones alpha chain
Cysteine 72 of Thyrotropin subunit beta
7xw5 X 31 Y 22
A redox-regulated disulphide may form between cysteine 55 of Glycoprotein hormones alpha chain and cysteine 22 of Thyrotropin subunit beta (31 and 22 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7xw5
Structure name
tshr-thyroid stimulating hormone-gs-ml109 complex
Structure deposition date
2022-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
55
Peptide B residue number
22
Ligandability
Cysteine 55 of Glycoprotein hormones alpha chain
Cysteine 22 of Thyrotropin subunit beta
7utz A 87 B 88
A redox-regulated disulphide may form between cysteine 111 of Glycoprotein hormones alpha chain and cysteine 108 of Thyrotropin subunit beta (87 and 88 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7utz
Structure name
human thyrotropin analog tr1402 bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2022-04-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
111
Peptide B residue number
108
Ligandability
Cysteine 111 of Glycoprotein hormones alpha chain
Cysteine 108 of Thyrotropin subunit beta
7t9i A 87 B 95
A redox-regulated disulphide may form between cysteine 111 of Glycoprotein hormones alpha chain and cysteine 115 of Thyrotropin subunit beta (87 and 95 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
111
Peptide B residue number
115
Ligandability
Cysteine 111 of Glycoprotein hormones alpha chain
Cysteine 115 of Thyrotropin subunit beta
7xw5 X 31 Y 72
A redox-regulated disulphide may form between cysteine 55 of Glycoprotein hormones alpha chain and cysteine 72 of Thyrotropin subunit beta (31 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7xw5
Structure name
tshr-thyroid stimulating hormone-gs-ml109 complex
Structure deposition date
2022-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
55
Peptide B residue number
72
Ligandability
Cysteine 55 of Glycoprotein hormones alpha chain
Cysteine 72 of Thyrotropin subunit beta
7t9i A 31 B 85
A redox-regulated disulphide may form between cysteine 55 of Glycoprotein hormones alpha chain and cysteine 105 of Thyrotropin subunit beta (31 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
55
Peptide B residue number
105
Ligandability
Cysteine 55 of Glycoprotein hormones alpha chain
Cysteine 105 of Thyrotropin subunit beta
7t9i A 31 B 31
A redox-regulated disulphide may form between cysteine 55 of Glycoprotein hormones alpha chain and cysteine 51 of Thyrotropin subunit beta (31 and 31 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
55
Peptide B residue number
51
Ligandability
Cysteine 55 of Glycoprotein hormones alpha chain
Cysteine 51 of Thyrotropin subunit beta
7utz A 87 B 31
A redox-regulated disulphide may form between cysteine 111 of Glycoprotein hormones alpha chain and cysteine 51 of Thyrotropin subunit beta (87 and 31 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7utz
Structure name
human thyrotropin analog tr1402 bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2022-04-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
111
Peptide B residue number
51
Ligandability
Cysteine 111 of Glycoprotein hormones alpha chain
Cysteine 51 of Thyrotropin subunit beta
7utz A 59 B 31
A redox-regulated disulphide may form between cysteine 83 of Glycoprotein hormones alpha chain and cysteine 51 of Thyrotropin subunit beta (59 and 31 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7utz
Structure name
human thyrotropin analog tr1402 bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2022-04-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
83
Peptide B residue number
51
Ligandability
Cysteine 83 of Glycoprotein hormones alpha chain
Cysteine 51 of Thyrotropin subunit beta
7xw5 X 87 Y 72
A redox-regulated disulphide may form between cysteine 111 of Glycoprotein hormones alpha chain and cysteine 72 of Thyrotropin subunit beta (87 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7xw5
Structure name
tshr-thyroid stimulating hormone-gs-ml109 complex
Structure deposition date
2022-05-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
111
Peptide B residue number
72
Ligandability
Cysteine 111 of Glycoprotein hormones alpha chain
Cysteine 72 of Thyrotropin subunit beta
7xw5 X 59 Y 72
A redox-regulated disulphide may form between cysteine 83 of Glycoprotein hormones alpha chain and cysteine 72 of Thyrotropin subunit beta (59 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7xw5
Structure name
tshr-thyroid stimulating hormone-gs-ml109 complex
Structure deposition date
2022-05-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glycoprotein hormones alpha chain
Peptide B name
Thyrotropin subunit beta
Peptide A accession
P01215
Peptide B accession
P01222
Peptide A residue number
83
Peptide B residue number
72
Ligandability
Cysteine 83 of Glycoprotein hormones alpha chain
Cysteine 72 of Thyrotropin subunit beta
7t9i B 16 B 67
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 36 and 87 (16 and 67 respectively in this structure).
Details
Redox score ?
90
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
36
Residue number B
87
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 36 of Thyrotropin subunit beta
Cysteine 87 of Thyrotropin subunit beta
7t9i B 19 B 105
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 39 and 125 (19 and 105 respectively in this structure).
Details
Redox score ?
88
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
39
Residue number B
125
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 39 of Thyrotropin subunit beta
Cysteine 125 of Thyrotropin subunit beta
7t9i B 27 B 83
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 47 and 103 (27 and 83 respectively in this structure).
Details
Redox score ?
84
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
47
Residue number B
103
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 47 of Thyrotropin subunit beta
Cysteine 103 of Thyrotropin subunit beta
7t9i B 2 B 52
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 22 and 72 (2 and 52 respectively in this structure).
Details
Redox score ?
84
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
22
Residue number B
72
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 22 of Thyrotropin subunit beta
Cysteine 72 of Thyrotropin subunit beta
7t9i B 31 B 85
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 51 and 105 (31 and 85 respectively in this structure).
Details
Redox score ?
82
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
51
Residue number B
105
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 51 of Thyrotropin subunit beta
Cysteine 105 of Thyrotropin subunit beta
7utz B 88 B 95
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 108 and 115 (88 and 95 respectively in this structure).
Details
Redox score ?
81
PDB code
7utz
Structure name
human thyrotropin analog tr1402 bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2022-04-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
108
Residue number B
115
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 108 of Thyrotropin subunit beta
Cysteine 115 of Thyrotropin subunit beta
7utz B 2 B 83
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 22 and 103 (2 and 83 respectively in this structure).
Details
Redox score ?
73
PDB code
7utz
Structure name
human thyrotropin analog tr1402 bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2022-04-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
22
Residue number B
103
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 22 of Thyrotropin subunit beta
Cysteine 103 of Thyrotropin subunit beta
7utz B 2 B 85
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 22 and 105 (2 and 85 respectively in this structure).
Details
Redox score ?
72
PDB code
7utz
Structure name
human thyrotropin analog tr1402 bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2022-04-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
22
Residue number B
105
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 22 of Thyrotropin subunit beta
Cysteine 105 of Thyrotropin subunit beta
7t9i B 2 B 31
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 22 and 51 (2 and 31 respectively in this structure).
Details
Redox score ?
69
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
22
Residue number B
51
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 22 of Thyrotropin subunit beta
Cysteine 51 of Thyrotropin subunit beta
7utz B 2 B 27
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 22 and 47 (2 and 27 respectively in this structure).
Details
Redox score ?
67
PDB code
7utz
Structure name
human thyrotropin analog tr1402 bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2022-04-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
22
Residue number B
47
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 22 of Thyrotropin subunit beta
Cysteine 47 of Thyrotropin subunit beta
7t9i B 52 B 83
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 72 and 103 (52 and 83 respectively in this structure).
Details
Redox score ?
62
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
72
Residue number B
103
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 72 of Thyrotropin subunit beta
Cysteine 103 of Thyrotropin subunit beta
7t9i B 31 B 52
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 51 and 72 (31 and 52 respectively in this structure).
Details
Redox score ?
62
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
51
Residue number B
72
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 51 of Thyrotropin subunit beta
Cysteine 72 of Thyrotropin subunit beta
7utz B 27 B 52
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 47 and 72 (27 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
7utz
Structure name
human thyrotropin analog tr1402 bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2022-04-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
47
Residue number B
72
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 47 of Thyrotropin subunit beta
Cysteine 72 of Thyrotropin subunit beta
7t9i B 52 B 85
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 72 and 105 (52 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
72
Residue number B
105
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 72 of Thyrotropin subunit beta
Cysteine 105 of Thyrotropin subunit beta
7t9i B 83 B 85
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 103 and 105 (83 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
103
Residue number B
105
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 103 of Thyrotropin subunit beta
Cysteine 105 of Thyrotropin subunit beta
7t9i B 31 B 83
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 51 and 103 (31 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
51
Residue number B
103
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 51 of Thyrotropin subunit beta
Cysteine 103 of Thyrotropin subunit beta
7utz B 27 B 85
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 47 and 105 (27 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7utz
Structure name
human thyrotropin analog tr1402 bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2022-04-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
47
Residue number B
105
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 47 of Thyrotropin subunit beta
Cysteine 105 of Thyrotropin subunit beta
7t9i B 27 B 31
A redox-regulated disulphide may form within Thyrotropin subunit beta between cysteines 47 and 51 (27 and 31 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01222
Residue number A
47
Residue number B
51
Peptide name
Thyrotropin subunit beta
Ligandability
Cysteine 47 of Thyrotropin subunit beta
Cysteine 51 of Thyrotropin subunit beta
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