ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Somatotropin

Intramolecular
Cysteine 208 and cysteine 215
Cysteine 79 and cysteine 191
A redox-regulated disulphide may form within Somatotropin between cysteines 208 and 215 (182 and 189 respectively in this structure).

Details

Redox score ?
85
PDB code
1axi
Structure name
structural plasticity at the hgh:hghbp interface
Structure deposition date
1997-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01241
Residue number A
208
Residue number B
215
Peptide name
Somatotropin

Ligandability

Cysteine 208 of Somatotropin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 215 of Somatotropin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Somatotropin between cysteines 79 and 191 (53 and 165 respectively in this structure).

Details

Redox score ?
83
PDB code
1bp3
Structure name
the xray structure of a growth hormone-prolactin receptor complex
Structure deposition date
1998-08-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01241
Residue number A
79
Residue number B
191
Peptide name
Somatotropin

Ligandability

Cysteine 79 of Somatotropin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 of Somatotropin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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