a tool for identifying drug-targetable redox-active disulphides

Calcitonin

Intramolecular

Cysteine 85 and cysteine 91

A redox-regulated disulphide may form within Calcitonin between cysteines 85 and 91 (1 and 7 respectively in this structure).

Details

Redox score ?

90

PDB code

Structure name

solution conformation of a non-amyloidogenic analogue of human calcitonin in sodium dodecyl sulfate micelles

Structure deposition date

2007-12-03

Thiol separation (Å)

2

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

85

Residue number B

91

Peptide name

Calcitonin

Ligandability

Cysteine 85 of Calcitonin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Calcitonin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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