ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Thyroglobulin

Intramolecular
Cysteine 408 and cysteine 607
Cysteine 773 and cysteine 898
Cysteine 1231 and cysteine 1245
Cysteine 1639 and cysteine 1662
Cysteine 408 and cysteine 608
Cysteine 1245 and cysteine 1281
Cysteine 1928 and cysteine 1939
Cysteine 1476 and cysteine 1490
Cysteine 1306 and cysteine 1356
Cysteine 1493 and cysteine 1510
More...
Cysteine 1215 and cysteine 1264
Cysteine 2134 and cysteine 2140
Cysteine 1514 and cysteine 1523
Cysteine 2442 and cysteine 2453
Cysteine 925 and cysteine 1031
Cysteine 1077 and cysteine 1108
Cysteine 1149 and cysteine 1169
Cysteine 301 and cysteine 319
Cysteine 662 and cysteine 687
Cysteine 364 and cysteine 620
Cysteine 164 and cysteine 183
Cysteine 96 and cysteine 120
Cysteine 1181 and cysteine 1188
Cysteine 1543 and cysteine 1565
Cysteine 1462 and cysteine 1473
Cysteine 1331 and cysteine 1347
Cysteine 1126 and cysteine 1145
Cysteine 1897 and cysteine 1904
Cysteine 131 and cysteine 138
Cysteine 1126 and cysteine 1145
Cysteine 1607 and cysteine 1613
Cysteine 330 and cysteine 336
Cysteine 63 and cysteine 70
Cysteine 631 and cysteine 636
Cysteine 34 and cysteine 52
Cysteine 2035 and cysteine 2048
Cysteine 338 and cysteine 358
Cysteine 1603 and cysteine 1627
Cysteine 774 and cysteine 898
Cysteine 2005 and cysteine 2076
A redox-regulated disulphide may form within Thyroglobulin between cysteines 408 and 607.

Details

Redox score ?
94
PDB code
7qtq
Structure name
structure of native, iodinated bovine thyroglobulin solved on strepavidin affinity grids
Structure deposition date
2022-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01267
Residue number A
408
Residue number B
607
Peptide name
Thyroglobulin

Ligandability

Cysteine 408 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 607 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 773 and 898.

Details

Redox score ?
94
PDB code
7qtq
Structure name
structure of native, iodinated bovine thyroglobulin solved on strepavidin affinity grids
Structure deposition date
2022-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01267
Residue number A
773
Residue number B
898
Peptide name
Thyroglobulin

Ligandability

Cysteine 773 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 898 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1231 and 1245.

Details

Redox score ?
91
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1231
Residue number B
1245
Peptide name
Thyroglobulin

Ligandability

Cysteine 1231 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1245 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1639 and 1662.

Details

Redox score ?
91
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1639
Residue number B
1662
Peptide name
Thyroglobulin

Ligandability

Cysteine 1639 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1662 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 408 and 608.

Details

Redox score ?
90
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
408
Residue number B
608
Peptide name
Thyroglobulin

Ligandability

Cysteine 408 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 608 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1245 and 1281.

Details

Redox score ?
89
PDB code
7qtq
Structure name
structure of native, iodinated bovine thyroglobulin solved on strepavidin affinity grids
Structure deposition date
2022-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01267
Residue number A
1245
Residue number B
1281
Peptide name
Thyroglobulin

Ligandability

Cysteine 1245 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1281 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1928 and 1939.

Details

Redox score ?
88
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1928
Residue number B
1939
Peptide name
Thyroglobulin

Ligandability

Cysteine 1928 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1939 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1476 and 1490.

Details

Redox score ?
88
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1476
Residue number B
1490
Peptide name
Thyroglobulin

Ligandability

Cysteine 1476 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1490 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1306 and 1356.

Details

Redox score ?
87
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1306
Residue number B
1356
Peptide name
Thyroglobulin

Ligandability

Cysteine 1306 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1356 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1493 and 1510.

Details

Redox score ?
87
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1493
Residue number B
1510
Peptide name
Thyroglobulin

Ligandability

Cysteine 1493 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1510 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1215 and 1264.

Details

Redox score ?
86
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1215
Residue number B
1264
Peptide name
Thyroglobulin

Ligandability

Cysteine 1215 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1264 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 2134 and 2140.

Details

Redox score ?
86
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
2134
Residue number B
2140
Peptide name
Thyroglobulin

Ligandability

Cysteine 2134 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2140 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1514 and 1523.

Details

Redox score ?
86
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1514
Residue number B
1523
Peptide name
Thyroglobulin

Ligandability

Cysteine 1514 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1523 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 2442 and 2453.

Details

Redox score ?
86
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
2442
Residue number B
2453
Peptide name
Thyroglobulin

Ligandability

Cysteine 2442 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2453 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 925 and 1031.

Details

Redox score ?
86
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
925
Residue number B
1031
Peptide name
Thyroglobulin

Ligandability

Cysteine 925 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1031 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1077 and 1108.

Details

Redox score ?
86
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1077
Residue number B
1108
Peptide name
Thyroglobulin

Ligandability

Cysteine 1077 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1108 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1149 and 1169.

Details

Redox score ?
86
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1149
Residue number B
1169
Peptide name
Thyroglobulin

Ligandability

Cysteine 1149 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1169 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 301 and 319.

Details

Redox score ?
86
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
301
Residue number B
319
Peptide name
Thyroglobulin

Ligandability

Cysteine 301 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 662 and 687.

Details

Redox score ?
85
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
662
Residue number B
687
Peptide name
Thyroglobulin

Ligandability

Cysteine 662 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 687 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 364 and 620.

Details

Redox score ?
85
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
364
Residue number B
620
Peptide name
Thyroglobulin

Ligandability

Cysteine 364 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 620 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 164 and 183.

Details

Redox score ?
85
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
164
Residue number B
183
Peptide name
Thyroglobulin

Ligandability

Cysteine 164 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 96 and 120.

Details

Redox score ?
85
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
96
Residue number B
120
Peptide name
Thyroglobulin

Ligandability

Cysteine 96 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1181 and 1188.

Details

Redox score ?
85
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1181
Residue number B
1188
Peptide name
Thyroglobulin

Ligandability

Cysteine 1181 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1188 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1543 and 1565.

Details

Redox score ?
85
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1543
Residue number B
1565
Peptide name
Thyroglobulin

Ligandability

Cysteine 1543 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1565 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1462 and 1473.

Details

Redox score ?
84
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1462
Residue number B
1473
Peptide name
Thyroglobulin

Ligandability

Cysteine 1462 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1473 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1331 and 1347.

Details

Redox score ?
84
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1331
Residue number B
1347
Peptide name
Thyroglobulin

Ligandability

Cysteine 1331 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1347 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1126 and 1145.

Details

Redox score ?
84
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1126
Residue number B
1145
Peptide name
Thyroglobulin

Ligandability

Cysteine 1126 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1145 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1897 and 1904.

Details

Redox score ?
84
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1897
Residue number B
1904
Peptide name
Thyroglobulin

Ligandability

Cysteine 1897 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1904 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 131 and 138.

Details

Redox score ?
84
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
131
Residue number B
138
Peptide name
Thyroglobulin

Ligandability

Cysteine 131 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1126 and 1145.

Details

Redox score ?
84
PDB code
7qtq
Structure name
structure of native, iodinated bovine thyroglobulin solved on strepavidin affinity grids
Structure deposition date
2022-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01267
Residue number A
1126
Residue number B
1145
Peptide name
Thyroglobulin

Ligandability

Cysteine 1126 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1145 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1607 and 1613.

Details

Redox score ?
84
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1607
Residue number B
1613
Peptide name
Thyroglobulin

Ligandability

Cysteine 1607 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1613 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 330 and 336.

Details

Redox score ?
84
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
330
Residue number B
336
Peptide name
Thyroglobulin

Ligandability

Cysteine 330 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 336 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 63 and 70.

Details

Redox score ?
84
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
63
Residue number B
70
Peptide name
Thyroglobulin

Ligandability

Cysteine 63 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 70 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 631 and 636.

Details

Redox score ?
84
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
631
Residue number B
636
Peptide name
Thyroglobulin

Ligandability

Cysteine 631 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 636 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 34 and 52.

Details

Redox score ?
84
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
34
Residue number B
52
Peptide name
Thyroglobulin

Ligandability

Cysteine 34 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 2035 and 2048.

Details

Redox score ?
83
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
2035
Residue number B
2048
Peptide name
Thyroglobulin

Ligandability

Cysteine 2035 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2048 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 338 and 358.

Details

Redox score ?
83
PDB code
6scj
Structure name
the structure of human thyroglobulin
Structure deposition date
2019-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
338
Residue number B
358
Peptide name
Thyroglobulin

Ligandability

Cysteine 338 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 358 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1603 and 1627.

Details

Redox score ?
83
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
1603
Residue number B
1627
Peptide name
Thyroglobulin

Ligandability

Cysteine 1603 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1627 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 774 and 898.

Details

Redox score ?
83
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
774
Residue number B
898
Peptide name
Thyroglobulin

Ligandability

Cysteine 774 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 898 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 2005 and 2076.

Details

Redox score ?
83
PDB code
7b75
Structure name
cryo-em structure of human thyroglobulin
Structure deposition date
2020-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01266
Residue number A
2005
Residue number B
2076
Peptide name
Thyroglobulin

Ligandability

Cysteine 2005 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2076 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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