Insulin-like growth factor II
Intermolecular
Cysteine 1521 of Insulin-like growth factor 2 receptor variant and cysteine 75
Cysteine 901 of Cation-independent mannose-6-phosphate receptor and cysteine 71
Intramolecular
Cysteine 45 and cysteine 84
Cysteine 70 and cysteine 75
Cysteine 33 and cysteine 71
Cysteine 33 and cysteine 75
Cysteine 71 and cysteine 75
Cysteine 70 and cysteine 71
Cysteine 33 and cysteine 70
2l29 A 1598 B 51
A redox-regulated disulphide may form between cysteine 1521 of Insulin-like growth factor 2 receptor variant and cysteine 75 of Insulin-like growth factor II (1598 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
2l29
Structure name
complex structure of e4 mutant human igf2r domain 11 bound to igf-ii
Structure deposition date
2010-08-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide A name
Insulin-like growth factor 2 receptor variant
Peptide B name
Insulin-like growth factor II
Peptide A accession
Q59EZ3
Peptide B accession
P01344
Peptide A residue number
1521
Peptide B residue number
75
Ligandability
Cysteine 1521 of Insulin-like growth factor 2 receptor variant
Cysteine 75 of Insulin-like growth factor II
6um2 A 901 B 47
A redox-regulated disulphide may form between cysteine 901 of Cation-independent mannose-6-phosphate receptor and cysteine 71 of Insulin-like growth factor II (901 and 47 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6um2
Structure name
structure of m-6-p/igfii receptor and igfii complex
Structure deposition date
2019-10-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Cation-independent mannose-6-phosphate receptor
Peptide B name
Insulin-like growth factor II
Peptide A accession
P08169
Peptide B accession
P01344
Peptide A residue number
901
Peptide B residue number
71
Ligandability
Cysteine 901 of Cation-independent mannose-6-phosphate receptor
Cysteine 71 of Insulin-like growth factor II
3kr3 D 21 D 60
A redox-regulated disulphide may form within Insulin-like growth factor II between cysteines 45 and 84 (21 and 60 respectively in this structure).
Details
Redox score ?
86
PDB code
3kr3
Structure name
crystal structure of igf-ii antibody complex
Structure deposition date
2009-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01344
Residue number A
45
Residue number B
84
Peptide name
Insulin-like growth factor II
Ligandability
Cysteine 45 of Insulin-like growth factor II
Cysteine 84 of Insulin-like growth factor II
2v5p D 46 D 51
A redox-regulated disulphide may form within Insulin-like growth factor II between cysteines 70 and 75 (46 and 51 respectively in this structure).
Details
Redox score ?
85
PDB code
2v5p
Structure name
complex structure of human igf2r domains 11-13 bound to igf-ii
Structure deposition date
2007-07-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01344
Residue number A
70
Residue number B
75
Peptide name
Insulin-like growth factor II
Ligandability
Cysteine 70 of Insulin-like growth factor II
Cysteine 75 of Insulin-like growth factor II
2v5p D 9 D 47
A redox-regulated disulphide may form within Insulin-like growth factor II between cysteines 33 and 71 (9 and 47 respectively in this structure).
Details
Redox score ?
85
PDB code
2v5p
Structure name
complex structure of human igf2r domains 11-13 bound to igf-ii
Structure deposition date
2007-07-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01344
Residue number A
33
Residue number B
71
Peptide name
Insulin-like growth factor II
Ligandability
Cysteine 33 of Insulin-like growth factor II
Cysteine 71 of Insulin-like growth factor II
3kr3 D 9 D 51
A redox-regulated disulphide may form within Insulin-like growth factor II between cysteines 33 and 75 (9 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3kr3
Structure name
crystal structure of igf-ii antibody complex
Structure deposition date
2009-11-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01344
Residue number A
33
Residue number B
75
Peptide name
Insulin-like growth factor II
Ligandability
Cysteine 33 of Insulin-like growth factor II
Cysteine 75 of Insulin-like growth factor II
3kr3 D 47 D 51
A redox-regulated disulphide may form within Insulin-like growth factor II between cysteines 71 and 75 (47 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3kr3
Structure name
crystal structure of igf-ii antibody complex
Structure deposition date
2009-11-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01344
Residue number A
71
Residue number B
75
Peptide name
Insulin-like growth factor II
Ligandability
Cysteine 71 of Insulin-like growth factor II
Cysteine 75 of Insulin-like growth factor II
2v5p D 46 D 47
A redox-regulated disulphide may form within Insulin-like growth factor II between cysteines 70 and 71 (46 and 47 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
2v5p
Structure name
complex structure of human igf2r domains 11-13 bound to igf-ii
Structure deposition date
2007-07-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01344
Residue number A
70
Residue number B
71
Peptide name
Insulin-like growth factor II
Ligandability
Cysteine 70 of Insulin-like growth factor II
Cysteine 71 of Insulin-like growth factor II
2v5p C 9 C 46
A redox-regulated disulphide may form within Insulin-like growth factor II between cysteines 33 and 70 (9 and 46 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
2v5p
Structure name
complex structure of human igf2r domains 11-13 bound to igf-ii
Structure deposition date
2007-07-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01344
Residue number A
33
Residue number B
70
Peptide name
Insulin-like growth factor II
Ligandability
Cysteine 33 of Insulin-like growth factor II
Cysteine 70 of Insulin-like growth factor II
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