ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interferon alpha-2

Intramolecular
Cysteine 24 and cysteine 121
Cysteine 52 and cysteine 161
A redox-regulated disulphide may form within Interferon alpha-2 between cysteines 24 and 121 (1 and 98 respectively in this structure).

Details

Redox score ?
87
PDB code
2lms
Structure name
a single galnac residue on threonine-106 modifies the dynamics and the structure of interferon alpha-2a around the glycosylation site
Structure deposition date
2011-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01563
Residue number A
24
Residue number B
121
Peptide name
Interferon alpha-2

Ligandability

Cysteine 24 of Interferon alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Interferon alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon alpha-2 between cysteines 52 and 161 (29 and 138 respectively in this structure).

Details

Redox score ?
84
PDB code
3s9d
Structure name
binary complex between ifna2 and ifnar2
Structure deposition date
2011-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01563
Residue number A
52
Residue number B
161
Peptide name
Interferon alpha-2

Ligandability

Cysteine 52 of Interferon alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 161 of Interferon alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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