ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interferon alpha-5

Intramolecular
Cysteine 24 and cysteine 122
Cysteine 52 and cysteine 162
A redox-regulated disulphide may form within Interferon alpha-5 between cysteines 24 and 122 (1 and 99 respectively in this structure).

Details

Redox score ?
88
PDB code
3oq3
Structure name
structural basis of type-i interferon sequestration by a poxvirus decoy receptor
Structure deposition date
2010-09-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07349
Residue number A
24
Residue number B
122
Peptide name
Interferon alpha-5

Ligandability

Cysteine 24 of Interferon alpha-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Interferon alpha-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon alpha-5 between cysteines 52 and 162 (29 and 139 respectively in this structure).

Details

Redox score ?
85
PDB code
3oq3
Structure name
structural basis of type-i interferon sequestration by a poxvirus decoy receptor
Structure deposition date
2010-09-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07349
Residue number A
52
Residue number B
162
Peptide name
Interferon alpha-5

Ligandability

Cysteine 52 of Interferon alpha-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Interferon alpha-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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