ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Erythropoietin

Intramolecular
Cysteine 56 and cysteine 60
Cysteine 34 and cysteine 188
A redox-regulated disulphide may form within Erythropoietin between cysteines 56 and 60 (29 and 33 respectively in this structure).

Details

Redox score ?
89
PDB code
1eer
Structure name
crystal structure of human erythropoietin complexed to its receptor at 1
Structure deposition date
1998-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01588
Residue number A
56
Residue number B
60
Peptide name
Erythropoietin

Ligandability

Cysteine 56 of Erythropoietin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 60 of Erythropoietin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Erythropoietin between cysteines 34 and 188 (7 and 161 respectively in this structure).

Details

Redox score ?
85
PDB code
1cn4
Structure name
erythropoietin complexed with extracellular domains of erythropoietin receptor
Structure deposition date
1999-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01588
Residue number A
34
Residue number B
188
Peptide name
Erythropoietin

Ligandability

Cysteine 34 of Erythropoietin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of Erythropoietin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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