Interleukin-2 receptor subunit alpha
Intramolecular
Cysteine 51 and cysteine 82
Cysteine 152 and cysteine 184
Cysteine 24 and cysteine 168
Cysteine 49 and cysteine 80
Cysteine 80 and cysteine 82
Cysteine 67 and cysteine 125
Cysteine 49 and cysteine 82
Cysteine 49 and cysteine 51
Cysteine 51 and cysteine 80
3nfp K 30 K 61
A redox-regulated disulphide may form within Interleukin-2 receptor subunit alpha between cysteines 51 and 82 (30 and 61 respectively in this structure).
Details
Redox score ?
92
PDB code
3nfp
Structure name
crystal structure of the fab fragment of therapeutic antibody daclizumab in complex with il-2ra (cd25) ectodomain
Structure deposition date
2010-06-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01589
Residue number A
51
Residue number B
82
Peptide name
Interleukin-2 receptor subunit alpha
Ligandability
Cysteine 51 of Interleukin-2 receptor subunit alpha
Cysteine 82 of Interleukin-2 receptor subunit alpha
2erj A 131 A 163
A redox-regulated disulphide may form within Interleukin-2 receptor subunit alpha between cysteines 152 and 184 (131 and 163 respectively in this structure).
Details
Redox score ?
88
PDB code
2erj
Structure name
crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2
Structure deposition date
2005-10-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01589
Residue number A
152
Residue number B
184
Peptide name
Interleukin-2 receptor subunit alpha
Ligandability
Cysteine 152 of Interleukin-2 receptor subunit alpha
Cysteine 184 of Interleukin-2 receptor subunit alpha
6vwu A 141 A 285
A redox-regulated disulphide may form within Interleukin-2 receptor subunit alpha between cysteines 24 and 168 (141 and 285 respectively in this structure).
Details
Redox score ?
84
PDB code
6vwu
Structure name
x-ray structure of alks 4230, a fusion of circularly permuted human interleukin-2 and interleukin-2 receptor alpha
Structure deposition date
2020-02-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01589
Residue number A
24
Residue number B
168
Peptide name
Interleukin-2 receptor subunit alpha
Ligandability
Cysteine 24 of Interleukin-2 receptor subunit alpha
Cysteine 168 of Interleukin-2 receptor subunit alpha
2b5i D 28 D 59
A redox-regulated disulphide may form within Interleukin-2 receptor subunit alpha between cysteines 49 and 80 (28 and 59 respectively in this structure).
Details
Redox score ?
83
PDB code
2b5i
Structure name
cytokine receptor complex
Structure deposition date
2005-09-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01589
Residue number A
49
Residue number B
80
Peptide name
Interleukin-2 receptor subunit alpha
Ligandability
Cysteine 49 of Interleukin-2 receptor subunit alpha
Cysteine 80 of Interleukin-2 receptor subunit alpha
3nfp K 59 K 61
A redox-regulated disulphide may form within Interleukin-2 receptor subunit alpha between cysteines 80 and 82 (59 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
3nfp
Structure name
crystal structure of the fab fragment of therapeutic antibody daclizumab in complex with il-2ra (cd25) ectodomain
Structure deposition date
2010-06-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01589
Residue number A
80
Residue number B
82
Peptide name
Interleukin-2 receptor subunit alpha
Ligandability
Cysteine 80 of Interleukin-2 receptor subunit alpha
Cysteine 82 of Interleukin-2 receptor subunit alpha
3iu3 J 46 J 104
A redox-regulated disulphide may form within Interleukin-2 receptor subunit alpha between cysteines 67 and 125 (46 and 104 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
3iu3
Structure name
crystal structure of the fab fragment of therapeutic antibody basiliximab in complex with il-2ra (cd25) ectodomain
Structure deposition date
2009-08-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
46
Peptide accession
P01589
Residue number A
67
Residue number B
125
Peptide name
Interleukin-2 receptor subunit alpha
Ligandability
Cysteine 67 of Interleukin-2 receptor subunit alpha
Cysteine 125 of Interleukin-2 receptor subunit alpha
2erj A 28 A 61
A redox-regulated disulphide may form within Interleukin-2 receptor subunit alpha between cysteines 49 and 82 (28 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
2erj
Structure name
crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2
Structure deposition date
2005-10-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01589
Residue number A
49
Residue number B
82
Peptide name
Interleukin-2 receptor subunit alpha
Ligandability
Cysteine 49 of Interleukin-2 receptor subunit alpha
Cysteine 82 of Interleukin-2 receptor subunit alpha
3iu3 J 28 J 30
A redox-regulated disulphide may form within Interleukin-2 receptor subunit alpha between cysteines 49 and 51 (28 and 30 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
3iu3
Structure name
crystal structure of the fab fragment of therapeutic antibody basiliximab in complex with il-2ra (cd25) ectodomain
Structure deposition date
2009-08-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01589
Residue number A
49
Residue number B
51
Peptide name
Interleukin-2 receptor subunit alpha
Ligandability
Cysteine 49 of Interleukin-2 receptor subunit alpha
Cysteine 51 of Interleukin-2 receptor subunit alpha
3iu3 J 30 J 59
A redox-regulated disulphide may form within Interleukin-2 receptor subunit alpha between cysteines 51 and 80 (30 and 59 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
3iu3
Structure name
crystal structure of the fab fragment of therapeutic antibody basiliximab in complex with il-2ra (cd25) ectodomain
Structure deposition date
2009-08-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01589
Residue number A
51
Residue number B
80
Peptide name
Interleukin-2 receptor subunit alpha
Ligandability
Cysteine 51 of Interleukin-2 receptor subunit alpha
Cysteine 80 of Interleukin-2 receptor subunit alpha
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