Immunoglobulin J chain
Intermolecular
Cysteine 452 of Immunoglobulin heavy constant mu and cysteine 91
Cysteine 339 of Immunoglobulin heavy constant alpha 2 and cysteine 91
Cysteine 478 of Igh protein and cysteine 36
Cysteine 37 and cysteine 452 of Immunoglobulin heavy constant mu
Cysteine 352 of Immunoglobulin heavy constant alpha 1 and cysteine 37
Cysteine 37 and cysteine 339 of Immunoglobulin heavy constant alpha 2
Cysteine 352 of Immunoglobulin heavy constant alpha 1 and cysteine 91
Cysteine 478 of Igh protein and cysteine 90
Cysteine 478 of Igh protein and cysteine 123
Cysteine 35 and cysteine 452 of Immunoglobulin heavy constant mu
More...Cysteine 452 of Immunoglobulin heavy constant mu and cysteine 123
Cysteine 352 of Immunoglobulin heavy constant alpha 1 and cysteine 35
Cysteine 35 and cysteine 339 of Immunoglobulin heavy constant alpha 2
Cysteine 478 of Igh protein and cysteine 34
Intramolecular
Cysteine 94 and cysteine 114
Cysteine 131 and cysteine 156
Cysteine 35 and cysteine 123
Cysteine 35 and cysteine 37
Cysteine 37 and cysteine 123
Cysteine 34 and cysteine 93
6kxs A 575 J 68
A redox-regulated disulphide may form between cysteine 452 of Immunoglobulin heavy constant mu and cysteine 91 of Immunoglobulin J chain (575 and 68 respectively in this structure).
Details
Redox score ?
88
PDB code
6kxs
Structure name
cryo-em structure of human igm-fc in complex with the j chain and the ectodomain of pigr
Structure deposition date
2019-09-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant mu
Peptide B name
Immunoglobulin J chain
Peptide A accession
P01871
Peptide B accession
P01591
Peptide A residue number
452
Peptide B residue number
91
Ligandability
Cysteine 452 of Immunoglobulin heavy constant mu
Cysteine 91 of Immunoglobulin J chain
6ue9 B 471 D 69
A redox-regulated disulphide may form between cysteine 339 of Immunoglobulin heavy constant alpha 2 and cysteine 91 of Immunoglobulin J chain (471 and 69 respectively in this structure).
Details
Redox score ?
83
PDB code
6ue9
Structure name
structure of tetrameric siga complex (class 2)
Structure deposition date
2019-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 2
Peptide B name
Immunoglobulin J chain
Peptide A accession
P01877
Peptide B accession
P01591
Peptide A residue number
339
Peptide B residue number
91
Ligandability
Cysteine 339 of Immunoglobulin heavy constant alpha 2
Cysteine 91 of Immunoglobulin J chain
7jg1 C 466 J 14
A redox-regulated disulphide may form between cysteine 478 of Igh protein and cysteine 36 of Immunoglobulin J chain (466 and 14 respectively in this structure).
Details
Redox score ?
83
PDB code
7jg1
Structure name
dimeric immunoglobin a (diga)
Structure deposition date
2020-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Igh protein
Peptide B name
Immunoglobulin J chain
Peptide A accession
Q99M22
Peptide B accession
P01592
Peptide A residue number
478
Peptide B residue number
36
Ligandability
Cysteine 478 of Igh protein
Cysteine 36 of Immunoglobulin J chain
7ytc J 14 L 575
A redox-regulated disulphide may form between cysteine 37 of Immunoglobulin J chain and cysteine 452 of Immunoglobulin heavy constant mu (14 and 575 respectively in this structure).
Details
Redox score ?
83
PDB code
7ytc
Structure name
cryo-em structure of human fcmr bound to igm-fc/j
Structure deposition date
2022-08-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin J chain
Peptide B name
Immunoglobulin heavy constant mu
Peptide A accession
P01591
Peptide B accession
P01871
Peptide A residue number
37
Peptide B residue number
452
Ligandability
Cysteine 37 of Immunoglobulin J chain
Cysteine 452 of Immunoglobulin heavy constant mu
6lx3 D 471 J 14
A redox-regulated disulphide may form between cysteine 352 of Immunoglobulin heavy constant alpha 1 and cysteine 37 of Immunoglobulin J chain (471 and 14 respectively in this structure).
Details
Redox score ?
82
PDB code
6lx3
Structure name
cryo-em structure of human secretory immunoglobulin a
Structure deposition date
2020-02-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin J chain
Peptide A accession
P01876
Peptide B accession
P01591
Peptide A residue number
352
Peptide B residue number
37
Ligandability
Cysteine 352 of Immunoglobulin heavy constant alpha 1
Cysteine 37 of Immunoglobulin J chain
6uea D 15 F 471
A redox-regulated disulphide may form between cysteine 37 of Immunoglobulin J chain and cysteine 339 of Immunoglobulin heavy constant alpha 2 (15 and 471 respectively in this structure).
Details
Redox score ?
82
PDB code
6uea
Structure name
structure of pentameric siga complex
Structure deposition date
2019-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin J chain
Peptide B name
Immunoglobulin heavy constant alpha 2
Peptide A accession
P01591
Peptide B accession
P01877
Peptide A residue number
37
Peptide B residue number
339
Ligandability
Cysteine 37 of Immunoglobulin J chain
Cysteine 339 of Immunoglobulin heavy constant alpha 2
6ue7 B 471 D 69
A redox-regulated disulphide may form between cysteine 352 of Immunoglobulin heavy constant alpha 1 and cysteine 91 of Immunoglobulin J chain (471 and 69 respectively in this structure).
Details
Redox score ?
80
PDB code
6ue7
Structure name
structure of dimeric siga complex
Structure deposition date
2019-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin J chain
Peptide A accession
P01876
Peptide B accession
P01591
Peptide A residue number
352
Peptide B residue number
91
Ligandability
Cysteine 352 of Immunoglobulin heavy constant alpha 1
Cysteine 91 of Immunoglobulin J chain
7jg1 A 466 J 68
A redox-regulated disulphide may form between cysteine 478 of Igh protein and cysteine 90 of Immunoglobulin J chain (466 and 68 respectively in this structure).
Details
Redox score ?
79
PDB code
7jg1
Structure name
dimeric immunoglobin a (diga)
Structure deposition date
2020-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide A name
Igh protein
Peptide B name
Immunoglobulin J chain
Peptide A accession
Q99M22
Peptide B accession
P01592
Peptide A residue number
478
Peptide B residue number
90
Ligandability
Cysteine 478 of Igh protein
Cysteine 90 of Immunoglobulin J chain
7jg1 C 466 J 101
A redox-regulated disulphide may form between cysteine 478 of Igh protein and cysteine 123 of Immunoglobulin J chain (466 and 101 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7jg1
Structure name
dimeric immunoglobin a (diga)
Structure deposition date
2020-07-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide A name
Igh protein
Peptide B name
Immunoglobulin J chain
Peptide A accession
Q99M22
Peptide B accession
P01592
Peptide A residue number
478
Peptide B residue number
123
Ligandability
Cysteine 478 of Igh protein
Cysteine 123 of Immunoglobulin J chain
7ytc J 12 L 575
A redox-regulated disulphide may form between cysteine 35 of Immunoglobulin J chain and cysteine 452 of Immunoglobulin heavy constant mu (12 and 575 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7ytc
Structure name
cryo-em structure of human fcmr bound to igm-fc/j
Structure deposition date
2022-08-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin J chain
Peptide B name
Immunoglobulin heavy constant mu
Peptide A accession
P01591
Peptide B accession
P01871
Peptide A residue number
35
Peptide B residue number
452
Ligandability
Cysteine 35 of Immunoglobulin J chain
Cysteine 452 of Immunoglobulin heavy constant mu
6kxs L 575 J 100
A redox-regulated disulphide may form between cysteine 452 of Immunoglobulin heavy constant mu and cysteine 123 of Immunoglobulin J chain (575 and 100 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6kxs
Structure name
cryo-em structure of human igm-fc in complex with the j chain and the ectodomain of pigr
Structure deposition date
2019-09-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant mu
Peptide B name
Immunoglobulin J chain
Peptide A accession
P01871
Peptide B accession
P01591
Peptide A residue number
452
Peptide B residue number
123
Ligandability
Cysteine 452 of Immunoglobulin heavy constant mu
Cysteine 123 of Immunoglobulin J chain
6ue7 F 471 D 13
A redox-regulated disulphide may form between cysteine 352 of Immunoglobulin heavy constant alpha 1 and cysteine 35 of Immunoglobulin J chain (471 and 13 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6ue7
Structure name
structure of dimeric siga complex
Structure deposition date
2019-09-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin J chain
Peptide A accession
P01876
Peptide B accession
P01591
Peptide A residue number
352
Peptide B residue number
35
Ligandability
Cysteine 352 of Immunoglobulin heavy constant alpha 1
Cysteine 35 of Immunoglobulin J chain
6ue8 D 13 F 471
A redox-regulated disulphide may form between cysteine 35 of Immunoglobulin J chain and cysteine 339 of Immunoglobulin heavy constant alpha 2 (13 and 471 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
6ue8
Structure name
structure of tetrameric siga complex (class 1)
Structure deposition date
2019-09-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin J chain
Peptide B name
Immunoglobulin heavy constant alpha 2
Peptide A accession
P01591
Peptide B accession
P01877
Peptide A residue number
35
Peptide B residue number
339
Ligandability
Cysteine 35 of Immunoglobulin J chain
Cysteine 339 of Immunoglobulin heavy constant alpha 2
7jg2 C 466 J 12
A redox-regulated disulphide may form between cysteine 478 of Igh protein and cysteine 34 of Immunoglobulin J chain (466 and 12 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7jg2
Structure name
secretory immunoglobin a (siga)
Structure deposition date
2020-07-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide A name
Igh protein
Peptide B name
Immunoglobulin J chain
Peptide A accession
Q99M22
Peptide B accession
P01592
Peptide A residue number
478
Peptide B residue number
34
Ligandability
Cysteine 478 of Igh protein
Cysteine 34 of Immunoglobulin J chain
6lxw J 71 J 91
A redox-regulated disulphide may form within Immunoglobulin J chain between cysteines 94 and 114 (71 and 91 respectively in this structure).
Details
Redox score ?
88
PDB code
6lxw
Structure name
cryo-em structure of human secretory immunoglobulin a in complex with the n-terminal domain of spsa
Structure deposition date
2020-02-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01591
Residue number A
94
Residue number B
114
Peptide name
Immunoglobulin J chain
Ligandability
Cysteine 94 of Immunoglobulin J chain
Cysteine 114 of Immunoglobulin J chain
6ue9 D 109 D 134
A redox-regulated disulphide may form within Immunoglobulin J chain between cysteines 131 and 156 (109 and 134 respectively in this structure).
Details
Redox score ?
84
PDB code
6ue9
Structure name
structure of tetrameric siga complex (class 2)
Structure deposition date
2019-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01591
Residue number A
131
Residue number B
156
Peptide name
Immunoglobulin J chain
Ligandability
Cysteine 131 of Immunoglobulin J chain
Cysteine 156 of Immunoglobulin J chain
6lxw J 12 J 100
A redox-regulated disulphide may form within Immunoglobulin J chain between cysteines 35 and 123 (12 and 100 respectively in this structure).
Details
Redox score ?
82
PDB code
6lxw
Structure name
cryo-em structure of human secretory immunoglobulin a in complex with the n-terminal domain of spsa
Structure deposition date
2020-02-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01591
Residue number A
35
Residue number B
123
Peptide name
Immunoglobulin J chain
Ligandability
Cysteine 35 of Immunoglobulin J chain
Cysteine 123 of Immunoglobulin J chain
7k0c D 13 D 15
A redox-regulated disulphide may form within Immunoglobulin J chain between cysteines 35 and 37 (13 and 15 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7k0c
Structure name
structure of secretory igm core
Structure deposition date
2020-09-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01591
Residue number A
35
Residue number B
37
Peptide name
Immunoglobulin J chain
Ligandability
Cysteine 35 of Immunoglobulin J chain
Cysteine 37 of Immunoglobulin J chain
7k0c D 15 D 101
A redox-regulated disulphide may form within Immunoglobulin J chain between cysteines 37 and 123 (15 and 101 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7k0c
Structure name
structure of secretory igm core
Structure deposition date
2020-09-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01591
Residue number A
37
Residue number B
123
Peptide name
Immunoglobulin J chain
Ligandability
Cysteine 37 of Immunoglobulin J chain
Cysteine 123 of Immunoglobulin J chain
7jg2 J 12 J 71
A redox-regulated disulphide may form within Immunoglobulin J chain between cysteines 34 and 93 (12 and 71 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7jg2
Structure name
secretory immunoglobin a (siga)
Structure deposition date
2020-07-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01592
Residue number A
34
Residue number B
93
Peptide name
Immunoglobulin J chain
Ligandability
Cysteine 34 of Immunoglobulin J chain
Cysteine 93 of Immunoglobulin J chain
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