ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig lambda-1 chain V region

Intramolecular
Cysteine 42 and cysteine 110
Cysteine 42 and cysteine 194
A redox-regulated disulphide may form within Ig lambda-1 chain V region between cysteines 42 and 110 (23 and 106 respectively in this structure).

Details

Redox score ?
79
PDB code
1p4b
Structure name
three-dimensional structure of a single chain fv fragment complexed with the peptide gcn4(7p-14p)
Structure deposition date
2003-04-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
94
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01723
Residue number A
42
Residue number B
110
Peptide name
Ig lambda-1 chain V region

Ligandability

Cysteine 42 of Ig lambda-1 chain V region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Ig lambda-1 chain V region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig lambda-1 chain V region between cysteines 42 and 194 (134 and 194 respectively in this structure).

Details

Redox score ?
nan
PDB code
1q0x
Structure name
anti-morphine antibody 9b1 unliganded form
Structure deposition date
2003-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01723
Residue number A
42
Residue number B
194
Peptide name
Ig lambda-1 chain V region

Ligandability

Cysteine 42 of Ig lambda-1 chain V region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of Ig lambda-1 chain V region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 134 has been assigned to correct residue.
Cysteine 194 in protein B could not be asigned to a Uniprot residue.
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