ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104

Intramolecular
Cysteine 41 and cysteine 109
Cysteine 41 and cysteine 194
A redox-regulated disulphide may form within Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104 between cysteines 41 and 109 (22 and 90 respectively in this structure).

Details

Redox score ?
78
PDB code
1a6v
Structure name
b1-8 fv fragment complexed with a (4-hydroxy-3-nitrophenyl) acetate compound
Structure deposition date
1998-03-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01724
Residue number A
41
Residue number B
109
Peptide name
Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104

Ligandability

Cysteine 41 of Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104 between cysteines 41 and 194 (134 and 194 respectively in this structure).

Details

Redox score ?
nan
PDB code
1q0y
Structure name
anti-morphine antibody 9b1 complexed with morphine
Structure deposition date
2003-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01724
Residue number A
41
Residue number B
194
Peptide name
Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104

Ligandability

Cysteine 41 of Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 134 has been assigned to correct residue.
Cysteine 194 in protein B could not be asigned to a Uniprot residue.
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