ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig lambda-1 chain V region S43

Intramolecular
Cysteine 41 and cysteine 98
Cysteine 41 and cysteine 109
A redox-regulated disulphide may form within Ig lambda-1 chain V region S43 between cysteines 41 and 98 (22 and 98 respectively in this structure).

Details

Redox score ?
79
PDB code
5n7b
Structure name
understanding the singular conformational landscape of the tn antigens: sulfur-for- oxygen substitution in the glycosidic linkage provides new insights into molecular recognition by an antibody
Structure deposition date
2017-02-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01727
Residue number A
41
Residue number B
98
Peptide name
Ig lambda-1 chain V region S43

Ligandability

Cysteine 41 of Ig lambda-1 chain V region S43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Ig lambda-1 chain V region S43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Ig lambda-1 chain V region S43 between cysteines 41 and 109 (1023 and 1088 respectively in this structure).

Details

Redox score ?
78
PDB code
5a2k
Structure name
crystal structure of scfv-sm3 in complex with apd-tgalnac-rp
Structure deposition date
2015-05-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01727
Residue number A
41
Residue number B
109
Peptide name
Ig lambda-1 chain V region S43

Ligandability

Cysteine 41 of Ig lambda-1 chain V region S43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Ig lambda-1 chain V region S43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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