ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Immunoglobulin lambda variable 2-8

Intramolecular
Cysteine 41 and cysteine 109
Cysteine 41 and cysteine 101
A redox-regulated disulphide may form within Immunoglobulin lambda variable 2-8 between cysteines 41 and 109 (22 and 90 respectively in this structure).

Details

Redox score ?
79
PDB code
1a8j
Structure name
immunoglobulin lambda light chain dimer (mcg) complex with aspartame
Structure deposition date
1998-03-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01709
Residue number A
41
Residue number B
109
Peptide name
Immunoglobulin lambda variable 2-8

Ligandability

Cysteine 41 of Immunoglobulin lambda variable 2-8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Immunoglobulin lambda variable 2-8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Immunoglobulin lambda variable 2-8 between cysteines 41 and 101 (22 and 101 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
4unv
Structure name
covalent dimer of lambda variable domains
Structure deposition date
2014-05-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
nan
Peptide accession
P01709
Residue number A
41
Residue number B
101
Peptide name
Immunoglobulin lambda variable 2-8

Ligandability

Cysteine 41 of Immunoglobulin lambda variable 2-8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Immunoglobulin lambda variable 2-8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 in protein B could not be asigned to a Uniprot residue.
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