T-cell surface glycoprotein CD4
Intermolecular
Cysteine 447 and cysteine 20 of Tyrosine-protein kinase Lck
Cysteine 445 and cysteine 20 of Tyrosine-protein kinase Lck
Cysteine 447 and cysteine 23 of Tyrosine-protein kinase Lck
Cysteine 445 and cysteine 23 of Tyrosine-protein kinase Lck
Intramolecular
Cysteine 155 and cysteine 184
Cysteine 445 and cysteine 447
Cysteine 41 and cysteine 109
Cysteine 328 and cysteine 370
1q68 A 422 B 20
A redox-regulated disulphide may form between cysteine 447 of T-cell surface glycoprotein CD4 and cysteine 20 of Tyrosine-protein kinase Lck (422 and 20 respectively in this structure).
Details
Redox score ?
90
PDB code
1q68
Structure name
solution structure of t-cell surface glycoprotein cd4 and proto- oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
35
Minimum pKa ?
6
% buried
0
Peptide A name
T-cell surface glycoprotein CD4
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01730
Peptide B accession
P06239
Peptide A residue number
447
Peptide B residue number
20
Ligandability
Cysteine 447 of T-cell surface glycoprotein CD4
Cysteine 20 of Tyrosine-protein kinase Lck
1q68 A 420 B 20
A redox-regulated disulphide may form between cysteine 445 of T-cell surface glycoprotein CD4 and cysteine 20 of Tyrosine-protein kinase Lck (420 and 20 respectively in this structure).
Details
Redox score ?
89
PDB code
1q68
Structure name
solution structure of t-cell surface glycoprotein cd4 and proto- oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
6
% buried
0
Peptide A name
T-cell surface glycoprotein CD4
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01730
Peptide B accession
P06239
Peptide A residue number
445
Peptide B residue number
20
Ligandability
Cysteine 445 of T-cell surface glycoprotein CD4
Cysteine 20 of Tyrosine-protein kinase Lck
1q68 A 422 B 23
A redox-regulated disulphide may form between cysteine 447 of T-cell surface glycoprotein CD4 and cysteine 23 of Tyrosine-protein kinase Lck (422 and 23 respectively in this structure).
Details
Redox score ?
85
PDB code
1q68
Structure name
solution structure of t-cell surface glycoprotein cd4 and proto- oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
32
Minimum pKa ?
8
% buried
0
Peptide A name
T-cell surface glycoprotein CD4
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01730
Peptide B accession
P06239
Peptide A residue number
447
Peptide B residue number
23
Ligandability
Cysteine 447 of T-cell surface glycoprotein CD4
Cysteine 23 of Tyrosine-protein kinase Lck
1q68 A 420 B 23
A redox-regulated disulphide may form between cysteine 445 of T-cell surface glycoprotein CD4 and cysteine 23 of Tyrosine-protein kinase Lck (420 and 23 respectively in this structure).
Details
Redox score ?
85
PDB code
1q68
Structure name
solution structure of t-cell surface glycoprotein cd4 and proto- oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
8
% buried
0
Peptide A name
T-cell surface glycoprotein CD4
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01730
Peptide B accession
P06239
Peptide A residue number
445
Peptide B residue number
23
Ligandability
Cysteine 445 of T-cell surface glycoprotein CD4
Cysteine 23 of Tyrosine-protein kinase Lck
4q6i C 130 C 159
A redox-regulated disulphide may form within T-cell surface glycoprotein CD4 between cysteines 155 and 184 (130 and 159 respectively in this structure).
Details
Redox score ?
85
PDB code
4q6i
Structure name
crystal structure of murine 2d5 fab, a potent anti-cd4 hiv-1- neutralizing antibody in complex with cd4
Structure deposition date
2014-04-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01730
Residue number A
155
Residue number B
184
Peptide name
T-cell surface glycoprotein CD4
Ligandability
Cysteine 155 of T-cell surface glycoprotein CD4
Cysteine 184 of T-cell surface glycoprotein CD4
1q68 A 420 A 422
A redox-regulated disulphide may form within T-cell surface glycoprotein CD4 between cysteines 445 and 447 (420 and 422 respectively in this structure).
Details
Redox score ?
82
PDB code
1q68
Structure name
solution structure of t-cell surface glycoprotein cd4 and proto- oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
0
Peptide accession
P01730
Residue number A
445
Residue number B
447
Peptide name
T-cell surface glycoprotein CD4
Ligandability
Cysteine 445 of T-cell surface glycoprotein CD4
Cysteine 447 of T-cell surface glycoprotein CD4
1wio A 16 A 84
A redox-regulated disulphide may form within T-cell surface glycoprotein CD4 between cysteines 41 and 109 (16 and 84 respectively in this structure).
Details
Redox score ?
78
PDB code
1wio
Structure name
structure of t-cell surface glycoprotein cd4, tetragonal crystal form
Structure deposition date
1996-12-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
71
Minimum pKa ?
8
% buried
82
Peptide accession
P01730
Residue number A
41
Residue number B
109
Peptide name
T-cell surface glycoprotein CD4
Ligandability
Cysteine 41 of T-cell surface glycoprotein CD4
Cysteine 109 of T-cell surface glycoprotein CD4
3t0e E 303 E 345
A redox-regulated disulphide may form within T-cell surface glycoprotein CD4 between cysteines 328 and 370 (303 and 345 respectively in this structure).
Details
Redox score ?
77
PDB code
3t0e
Structure name
crystal structure of a complete ternary complex of t cell receptor, peptide-mhc and cd4
Structure deposition date
2011-07-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
78
Peptide accession
P01730
Residue number A
328
Residue number B
370
Peptide name
T-cell surface glycoprotein CD4
Ligandability
Cysteine 328 of T-cell surface glycoprotein CD4
Cysteine 370 of T-cell surface glycoprotein CD4
If this tool was useful for finding a disulphide, please cite: