T-cell surface glycoprotein CD8 alpha chain
Intermolecular
Cysteine 217 and cysteine 23 of Tyrosine-protein kinase Lck
Cysteine 215 and cysteine 23 of Tyrosine-protein kinase Lck
Cysteine 217 and cysteine 20 of Tyrosine-protein kinase Lck
Cysteine 215 and cysteine 20 of Tyrosine-protein kinase Lck
Intramolecular
Cysteine 215 and cysteine 217
Cysteine 43 and cysteine 54
Cysteine 54 and cysteine 115
Cysteine 43 and cysteine 115
1q69 A 196 B 23
A redox-regulated disulphide may form between cysteine 217 of T-cell surface glycoprotein CD8 alpha chain and cysteine 23 of Tyrosine-protein kinase Lck (196 and 23 respectively in this structure).
Details
Redox score ?
89
PDB code
1q69
Structure name
solution structure of t-cell surface glycoprotein cd8 alpha chain and proto-oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
6
% buried
0
Peptide A name
T-cell surface glycoprotein CD8 alpha chain
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01732
Peptide B accession
P06239
Peptide A residue number
217
Peptide B residue number
23
Ligandability
Cysteine 217 of T-cell surface glycoprotein CD8 alpha chain
Cysteine 23 of Tyrosine-protein kinase Lck
1q69 A 194 B 23
A redox-regulated disulphide may form between cysteine 215 of T-cell surface glycoprotein CD8 alpha chain and cysteine 23 of Tyrosine-protein kinase Lck (194 and 23 respectively in this structure).
Details
Redox score ?
88
PDB code
1q69
Structure name
solution structure of t-cell surface glycoprotein cd8 alpha chain and proto-oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
6
% buried
0
Peptide A name
T-cell surface glycoprotein CD8 alpha chain
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01732
Peptide B accession
P06239
Peptide A residue number
215
Peptide B residue number
23
Ligandability
Cysteine 215 of T-cell surface glycoprotein CD8 alpha chain
Cysteine 23 of Tyrosine-protein kinase Lck
1q69 A 196 B 20
A redox-regulated disulphide may form between cysteine 217 of T-cell surface glycoprotein CD8 alpha chain and cysteine 20 of Tyrosine-protein kinase Lck (196 and 20 respectively in this structure).
Details
Redox score ?
86
PDB code
1q69
Structure name
solution structure of t-cell surface glycoprotein cd8 alpha chain and proto-oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
0
Peptide A name
T-cell surface glycoprotein CD8 alpha chain
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01732
Peptide B accession
P06239
Peptide A residue number
217
Peptide B residue number
20
Ligandability
Cysteine 217 of T-cell surface glycoprotein CD8 alpha chain
Cysteine 20 of Tyrosine-protein kinase Lck
1q69 A 194 B 20
A redox-regulated disulphide may form between cysteine 215 of T-cell surface glycoprotein CD8 alpha chain and cysteine 20 of Tyrosine-protein kinase Lck (194 and 20 respectively in this structure).
Details
Redox score ?
85
PDB code
1q69
Structure name
solution structure of t-cell surface glycoprotein cd8 alpha chain and proto-oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
0
Peptide A name
T-cell surface glycoprotein CD8 alpha chain
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01732
Peptide B accession
P06239
Peptide A residue number
215
Peptide B residue number
20
Ligandability
Cysteine 215 of T-cell surface glycoprotein CD8 alpha chain
Cysteine 20 of Tyrosine-protein kinase Lck
1q69 A 194 A 196
A redox-regulated disulphide may form within T-cell surface glycoprotein CD8 alpha chain between cysteines 215 and 217 (194 and 196 respectively in this structure).
Details
Redox score ?
84
PDB code
1q69
Structure name
solution structure of t-cell surface glycoprotein cd8 alpha chain and proto-oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
10
% buried
0
Peptide accession
P01732
Residue number A
215
Residue number B
217
Peptide name
T-cell surface glycoprotein CD8 alpha chain
Ligandability
Cysteine 215 of T-cell surface glycoprotein CD8 alpha chain
Cysteine 217 of T-cell surface glycoprotein CD8 alpha chain
3qzw J 22 J 33
A redox-regulated disulphide may form within T-cell surface glycoprotein CD8 alpha chain between cysteines 43 and 54 (22 and 33 respectively in this structure).
Details
Redox score ?
65
PDB code
3qzw
Structure name
plasticity of human cd8 binding to peptide-hla-a*2402
Structure deposition date
2011-03-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
nan
Peptide accession
P01732
Residue number A
43
Residue number B
54
Peptide name
T-cell surface glycoprotein CD8 alpha chain
Ligandability
Cysteine 43 of T-cell surface glycoprotein CD8 alpha chain
Cysteine 54 of T-cell surface glycoprotein CD8 alpha chain
3qzw I 33 I 94
A redox-regulated disulphide may form within T-cell surface glycoprotein CD8 alpha chain between cysteines 54 and 115 (33 and 94 respectively in this structure).
Details
Redox score ?
63
PDB code
3qzw
Structure name
plasticity of human cd8 binding to peptide-hla-a*2402
Structure deposition date
2011-03-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
nan
Peptide accession
P01732
Residue number A
54
Residue number B
115
Peptide name
T-cell surface glycoprotein CD8 alpha chain
Ligandability
Cysteine 54 of T-cell surface glycoprotein CD8 alpha chain
Cysteine 115 of T-cell surface glycoprotein CD8 alpha chain
8ew6 W 22 W 94
A redox-regulated disulphide may form within T-cell surface glycoprotein CD8 alpha chain between cysteines 43 and 115 (22 and 94 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
8ew6
Structure name
anti-human cd8 vhh complex with cd8 alpha
Structure deposition date
2022-10-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
85
Minimum pKa ?
14
% buried
99
Peptide accession
P01732
Residue number A
43
Residue number B
115
Peptide name
T-cell surface glycoprotein CD8 alpha chain
Ligandability
Cysteine 43 of T-cell surface glycoprotein CD8 alpha chain
Cysteine 115 of T-cell surface glycoprotein CD8 alpha chain
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