ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Polymeric immunoglobulin receptor

Intermolecular
Cysteine 486 and cysteine 179 of Immunoglobulin heavy constant alpha 2
Cysteine 192 of Immunoglobulin heavy constant alpha 1 and cysteine 486
Cysteine 291 of Immunoglobulin heavy constant mu and cysteine 486
Intramolecular
Cysteine 486 and cysteine 520
Cysteine 271 and cysteine 279
Cysteine 496 and cysteine 503
Cysteine 257 and cysteine 325
Cysteine 152 and cysteine 220
Cysteine 40 and cysteine 110
Cysteine 56 and cysteine 64
More...
Cysteine 385 and cysteine 395
Cysteine 482 and cysteine 544
Cysteine 371 and cysteine 441
Cysteine 166 and cysteine 173
Cysteine 56 and cysteine 110
Cysteine 271 and cysteine 325
Cysteine 166 and cysteine 220
Cysteine 385 and cysteine 441
Cysteine 482 and cysteine 520
Cysteine 520 and cysteine 544
Cysteine 173 and cysteine 220
Cysteine 371 and cysteine 385
Cysteine 64 and cysteine 110
Cysteine 496 and cysteine 544
Cysteine 395 and cysteine 441
Cysteine 152 and cysteine 166
A redox-regulated disulphide may form between cysteine 486 of Polymeric immunoglobulin receptor and cysteine 179 of Immunoglobulin heavy constant alpha 2 (468 and 311 respectively in this structure).

Details

Redox score ?
84
PDB code
6uea
Structure name
structure of pentameric siga complex
Structure deposition date
2019-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide A name
Polymeric immunoglobulin receptor
Peptide B name
Immunoglobulin heavy constant alpha 2
Peptide A accession
P01833
Peptide B accession
P01877
Peptide A residue number
486
Peptide B residue number
179

Ligandability

Cysteine 486 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Immunoglobulin heavy constant alpha 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 192 of Immunoglobulin heavy constant alpha 1 and cysteine 486 of Polymeric immunoglobulin receptor (311 and 468 respectively in this structure).

Details

Redox score ?
65
PDB code
6lx3
Structure name
cryo-em structure of human secretory immunoglobulin a
Structure deposition date
2020-02-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
45
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Polymeric immunoglobulin receptor
Peptide A accession
P01876
Peptide B accession
P01833
Peptide A residue number
192
Peptide B residue number
486

Ligandability

Cysteine 192 of Immunoglobulin heavy constant alpha 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 486 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 291 of Immunoglobulin heavy constant mu and cysteine 486 of Polymeric immunoglobulin receptor (414 and 468 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6kxs
Structure name
cryo-em structure of human igm-fc in complex with the j chain and the ectodomain of pigr
Structure deposition date
2019-09-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
12
Peptide A name
Immunoglobulin heavy constant mu
Peptide B name
Polymeric immunoglobulin receptor
Peptide A accession
P01871
Peptide B accession
P01833
Peptide A residue number
291
Peptide B residue number
486

Ligandability

Cysteine 291 of Immunoglobulin heavy constant mu

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 486 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 486 and 520 (468 and 502 respectively in this structure).

Details

Redox score ?
88
PDB code
5d4k
Structure name
crystal structure of the human polymeric ig receptor (pigr) ectodomain
Structure deposition date
2015-08-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
486
Residue number B
520
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 486 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 520 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 271 and 279 (253 and 261 respectively in this structure).

Details

Redox score ?
87
PDB code
5d4k
Structure name
crystal structure of the human polymeric ig receptor (pigr) ectodomain
Structure deposition date
2015-08-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
271
Residue number B
279
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 271 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 496 and 503 (478 and 485 respectively in this structure).

Details

Redox score ?
82
PDB code
5d4k
Structure name
crystal structure of the human polymeric ig receptor (pigr) ectodomain
Structure deposition date
2015-08-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
496
Residue number B
503
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 496 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 503 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 257 and 325 (239 and 307 respectively in this structure).

Details

Redox score ?
81
PDB code
5d4k
Structure name
crystal structure of the human polymeric ig receptor (pigr) ectodomain
Structure deposition date
2015-08-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
257
Residue number B
325
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 257 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 152 and 220 (134 and 202 respectively in this structure).

Details

Redox score ?
80
PDB code
5d4k
Structure name
crystal structure of the human polymeric ig receptor (pigr) ectodomain
Structure deposition date
2015-08-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
152
Residue number B
220
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 152 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 40 and 110 (22 and 92 respectively in this structure).

Details

Redox score ?
79
PDB code
1xed
Structure name
crystal structure of a ligand-binding domain of the human polymeric ig receptor, pigr
Structure deposition date
2004-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
40
Residue number B
110
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 40 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 56 and 64 (38 and 46 respectively in this structure).

Details

Redox score ?
79
PDB code
6ue8
Structure name
structure of tetrameric siga complex (class 1)
Structure deposition date
2019-09-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
7
% buried
78
Peptide accession
P01833
Residue number A
56
Residue number B
64
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 56 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 385 and 395 (367 and 377 respectively in this structure).

Details

Redox score ?
79
PDB code
7k0c
Structure name
structure of secretory igm core
Structure deposition date
2020-09-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
71
Peptide accession
P01833
Residue number A
385
Residue number B
395
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 385 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 395 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 482 and 544 (464 and 526 respectively in this structure).

Details

Redox score ?
78
PDB code
5d4k
Structure name
crystal structure of the human polymeric ig receptor (pigr) ectodomain
Structure deposition date
2015-08-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
482
Residue number B
544
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 482 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 544 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 371 and 441 (353 and 423 respectively in this structure).

Details

Redox score ?
70
PDB code
7k0c
Structure name
structure of secretory igm core
Structure deposition date
2020-09-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
80
Minimum pKa ?
9
% buried
98
Peptide accession
P01833
Residue number A
371
Residue number B
441
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 371 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 441 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 166 and 173 (148 and 155 respectively in this structure).

Details

Redox score ?
64
PDB code
7jg2
Structure name
secretory immunoglobin a (siga)
Structure deposition date
2020-07-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
21
Peptide accession
O70570
Residue number A
166
Residue number B
173
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 166 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 56 and 110 (38 and 92 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
1xed
Structure name
crystal structure of a ligand-binding domain of the human polymeric ig receptor, pigr
Structure deposition date
2004-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
56
Residue number B
110
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 56 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 271 and 325 (253 and 307 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5d4k
Structure name
crystal structure of the human polymeric ig receptor (pigr) ectodomain
Structure deposition date
2015-08-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
271
Residue number B
325
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 271 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 166 and 220. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4nof
Structure name
crystal structure of the second ig domain from mouse polymeric immunoglobulin receptor [psi-nysgrc-006220]
Structure deposition date
2013-11-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O70570
Residue number A
166
Residue number B
220
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 166 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 385 and 441 (367 and 423 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5d4k
Structure name
crystal structure of the human polymeric ig receptor (pigr) ectodomain
Structure deposition date
2015-08-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
385
Residue number B
441
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 385 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 441 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 482 and 520 (464 and 502 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6ue8
Structure name
structure of tetrameric siga complex (class 1)
Structure deposition date
2019-09-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
nan
Peptide accession
P01833
Residue number A
482
Residue number B
520
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 482 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 520 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 520 and 544 (502 and 526 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6ue8
Structure name
structure of tetrameric siga complex (class 1)
Structure deposition date
2019-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
nan
Peptide accession
P01833
Residue number A
520
Residue number B
544
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 520 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 544 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 173 and 220. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4nof
Structure name
crystal structure of the second ig domain from mouse polymeric immunoglobulin receptor [psi-nysgrc-006220]
Structure deposition date
2013-11-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O70570
Residue number A
173
Residue number B
220
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 173 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 371 and 385 (353 and 367 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5d4k
Structure name
crystal structure of the human polymeric ig receptor (pigr) ectodomain
Structure deposition date
2015-08-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
371
Residue number B
385
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 371 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 385 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 64 and 110 (46 and 92 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1xed
Structure name
crystal structure of a ligand-binding domain of the human polymeric ig receptor, pigr
Structure deposition date
2004-09-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
64
Residue number B
110
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 64 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 496 and 544 (478 and 526 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5d4k
Structure name
crystal structure of the human polymeric ig receptor (pigr) ectodomain
Structure deposition date
2015-08-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
496
Residue number B
544
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 496 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 544 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 395 and 441 (377 and 423 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5d4k
Structure name
crystal structure of the human polymeric ig receptor (pigr) ectodomain
Structure deposition date
2015-08-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01833
Residue number A
395
Residue number B
441
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 395 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 441 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polymeric immunoglobulin receptor between cysteines 152 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
4nof
Structure name
crystal structure of the second ig domain from mouse polymeric immunoglobulin receptor [psi-nysgrc-006220]
Structure deposition date
2013-11-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O70570
Residue number A
152
Residue number B
166
Peptide name
Polymeric immunoglobulin receptor

Ligandability

Cysteine 152 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 166 of Polymeric immunoglobulin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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