Immunoglobulin kappa constant
Intermolecular
Cysteine 107 and cysteine 238 of IGH@ protein
Cysteine 107 and cysteine 222 of Immunoglobulin gamma-1 heavy chain
Cysteine 239 of IgG H chain and cysteine 107
Cysteine 107 and cysteine 135 of Ig heavy chain Mem5
Cysteine 107 and cysteine 14 of Ig gamma-2A chain C region, membrane-bound form
Cysteine 107 and cysteine 102 of Ig gamma-1 chain C region, membrane-bound form
Cysteine 107 and cysteine 103 of Immunoglobulin heavy constant gamma 1
Intramolecular
Cysteine 27 and cysteine 87
Cysteine 27 and cysteine 93
6bah A 214 B 223
A redox-regulated disulphide may form between cysteine 107 of Immunoglobulin kappa constant and cysteine 238 of IGH@ protein (214 and 223 respectively in this structure).
Details
Redox score ?
94
PDB code
6bah
Structure name
trastuzumab fab v3 with 5-diphenyl meditope variant
Structure deposition date
2017-10-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin kappa constant
Peptide B name
IGH@ protein
Peptide A accession
P01834
Peptide B accession
Q6GMX6
Peptide A residue number
107
Peptide B residue number
238
Ligandability
Cysteine 107 of Immunoglobulin kappa constant
Cysteine 238 of IGH@ protein
6oge B 214 C 216
A redox-regulated disulphide may form between cysteine 107 of Immunoglobulin kappa constant and cysteine 222 of Immunoglobulin gamma-1 heavy chain (214 and 216 respectively in this structure).
Details
Redox score ?
94
PDB code
6oge
Structure name
cryo-em structure of her2 extracellular domain-trastuzumab fab- pertuzumab fab complex
Structure deposition date
2019-04-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin kappa constant
Peptide B name
Immunoglobulin gamma-1 heavy chain
Peptide A accession
P01834
Peptide B accession
P0DOX5
Peptide A residue number
107
Peptide B residue number
222
Ligandability
Cysteine 107 of Immunoglobulin kappa constant
Cysteine 222 of Immunoglobulin gamma-1 heavy chain
5veb A 221 B 215
A redox-regulated disulphide may form between cysteine 239 of IgG H chain and cysteine 107 of Immunoglobulin kappa constant (221 and 215 respectively in this structure).
Details
Redox score ?
94
PDB code
5veb
Structure name
crystal structure of a fab binding to extracellular domain 5 of cadherin-6
Structure deposition date
2017-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
IgG H chain
Peptide B name
Immunoglobulin kappa constant
Peptide A accession
S6B291
Peptide B accession
P01834
Peptide A residue number
239
Peptide B residue number
107
Ligandability
Cysteine 239 of IgG H chain
Cysteine 107 of Immunoglobulin kappa constant
2mpa L 219 H 136
A redox-regulated disulphide may form between cysteine 107 of Immunoglobulin kappa constant and cysteine 135 of Ig heavy chain Mem5 (219 and 136 respectively in this structure).
Details
Redox score ?
90
PDB code
2mpa
Structure name
bactericidal antibody against neisseria meningitidis
Structure deposition date
1999-06-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin kappa constant
Peptide B name
Ig heavy chain Mem5
Peptide A accession
P01837
Peptide B accession
P84751
Peptide A residue number
107
Peptide B residue number
135
Ligandability
Cysteine 107 of Immunoglobulin kappa constant
Cysteine 135 of Ig heavy chain Mem5
1nby A 214 B 428
A redox-regulated disulphide may form between cysteine 107 of Immunoglobulin kappa constant and cysteine 14 of Ig gamma-2A chain C region, membrane-bound form (214 and 428 respectively in this structure).
Details
Redox score ?
89
PDB code
1nby
Structure name
crystal structure of hyhel-63 complexed with hel mutant k96a
Structure deposition date
2002-12-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide A name
Immunoglobulin kappa constant
Peptide B name
Ig gamma-2A chain C region, membrane-bound form
Peptide A accession
P01837
Peptide B accession
P01865
Peptide A residue number
107
Peptide B residue number
14
Ligandability
Cysteine 107 of Immunoglobulin kappa constant
Cysteine 14 of Ig gamma-2A chain C region, membrane-bound form
1kcr L 213 H 218
A redox-regulated disulphide may form between cysteine 107 of Immunoglobulin kappa constant and cysteine 102 of Ig gamma-1 chain C region, membrane-bound form (213 and 218 respectively in this structure).
Details
Redox score ?
88
PDB code
1kcr
Structure name
crystal structure of antibody pc283 in complex with ps1 peptide
Structure deposition date
2001-11-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide A name
Immunoglobulin kappa constant
Peptide B name
Ig gamma-1 chain C region, membrane-bound form
Peptide A accession
P01837
Peptide B accession
P01869
Peptide A residue number
107
Peptide B residue number
102
Ligandability
Cysteine 107 of Immunoglobulin kappa constant
Cysteine 102 of Ig gamma-1 chain C region, membrane-bound form
1i7z C 214 D 228
A redox-regulated disulphide may form between cysteine 107 of Immunoglobulin kappa constant and cysteine 103 of Immunoglobulin heavy constant gamma 1 (214 and 228 respectively in this structure).
Details
Redox score ?
70
PDB code
1i7z
Structure name
antibody gnc92h2 bound to ligand
Structure deposition date
2001-03-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide A name
Immunoglobulin kappa constant
Peptide B name
Immunoglobulin heavy constant gamma 1
Peptide A accession
P01834
Peptide B accession
P01857
Peptide A residue number
107
Peptide B residue number
103
Ligandability
Cysteine 107 of Immunoglobulin kappa constant
Cysteine 103 of Immunoglobulin heavy constant gamma 1
4d9r D 134 D 194
A redox-regulated disulphide may form within Immunoglobulin kappa constant between cysteines 27 and 87 (134 and 194 respectively in this structure).
Details
Redox score ?
77
PDB code
4d9r
Structure name
inhibiting alternative pathway complement activation by targeting the exosite on factor d
Structure deposition date
2012-01-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01834
Residue number A
27
Residue number B
87
Peptide name
Immunoglobulin kappa constant
Ligandability
Cysteine 27 of Immunoglobulin kappa constant
Cysteine 87 of Immunoglobulin kappa constant
2mpa L 23 L 93
A redox-regulated disulphide may form within Immunoglobulin kappa constant between cysteines 27 and 93 (23 and 93 respectively in this structure).
Details
Redox score ?
nan
PDB code
2mpa
Structure name
bactericidal antibody against neisseria meningitidis
Structure deposition date
1999-06-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01837
Residue number A
27
Residue number B
93
Peptide name
Immunoglobulin kappa constant
Ligandability
Cysteine 27 of Immunoglobulin kappa constant
Cysteine 93 of Immunoglobulin kappa constant
Cysteine 93 in protein B could not be asigned to a Uniprot residue.
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