Immunoglobulin heavy constant epsilon
Intermolecular
Cysteine 121 and cysteine 209
Cysteine 209 and cysteine 209
Cysteine 239 and cysteine 335
Intramolecular
Cysteine 239 and cysteine 299
Cysteine 135 and cysteine 193
Cysteine 345 and cysteine 405
5lgk C 241 D 328
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant epsilon at cysteines 121 and 209 (241 and 328 respectively in this structure).
Details
Redox score ?
78
PDB code
5lgk
Structure name
crystal structure of the human ige-fc bound to its b cell receptor dercd23
Structure deposition date
2016-07-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
3
% buried
89
Peptide A name
Immunoglobulin heavy constant epsilon
Peptide B name
Immunoglobulin heavy constant epsilon
Peptide A accession
P01854
Peptide B accession
P01854
Peptide A residue number
121
Peptide B residue number
209
Ligandability
Cysteine 121 of Immunoglobulin heavy constant epsilon
Cysteine 209 of Immunoglobulin heavy constant epsilon
2y7q B 328 D 328
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant epsilon at cysteines 209 and 209 (328 and 328 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
2y7q
Structure name
the high-affinity complex between ige and its receptor fc epsilon ri
Structure deposition date
2011-02-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant epsilon
Peptide B name
Immunoglobulin heavy constant epsilon
Peptide A accession
P01854
Peptide B accession
P01854
Peptide A residue number
209
Peptide B residue number
209
Ligandability
4grg C 335 D 335
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant epsilon at cysteines 239 and 335 (335 and 335 respectively in this structure).
Details
Redox score ?
nan
PDB code
4grg
Structure name
crystal structure of ige complexed with e2_79, an anti-ige inhibitor
Structure deposition date
2012-08-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant epsilon
Peptide B name
Immunoglobulin heavy constant epsilon
Peptide A accession
P01854
Peptide B accession
P01854
Peptide A residue number
239
Peptide B residue number
335
Ligandability
Cysteine 239 of Immunoglobulin heavy constant epsilon
Cysteine 335 of Immunoglobulin heavy constant epsilon
Cysteine 335 in protein B could not be asigned to a Uniprot residue.
5lgj A 358 A 418
A redox-regulated disulphide may form within Immunoglobulin heavy constant epsilon between cysteines 239 and 299 (358 and 418 respectively in this structure).
Details
Redox score ?
75
PDB code
5lgj
Structure name
the crystal structure of ige fc mutant - p333c
Structure deposition date
2016-07-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
84
Peptide accession
P01854
Residue number A
239
Residue number B
299
Peptide name
Immunoglobulin heavy constant epsilon
Ligandability
Cysteine 239 of Immunoglobulin heavy constant epsilon
Cysteine 299 of Immunoglobulin heavy constant epsilon
5lgk D 254 D 312
A redox-regulated disulphide may form within Immunoglobulin heavy constant epsilon between cysteines 135 and 193 (254 and 312 respectively in this structure).
Details
Redox score ?
74
PDB code
5lgk
Structure name
crystal structure of the human ige-fc bound to its b cell receptor dercd23
Structure deposition date
2016-07-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
7
% buried
69
Peptide accession
P01854
Residue number A
135
Residue number B
193
Peptide name
Immunoglobulin heavy constant epsilon
Ligandability
Cysteine 135 of Immunoglobulin heavy constant epsilon
Cysteine 193 of Immunoglobulin heavy constant epsilon
5lgk A 464 A 524
A redox-regulated disulphide may form within Immunoglobulin heavy constant epsilon between cysteines 345 and 405 (464 and 524 respectively in this structure).
Details
Redox score ?
71
PDB code
5lgk
Structure name
crystal structure of the human ige-fc bound to its b cell receptor dercd23
Structure deposition date
2016-07-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
95
Peptide accession
P01854
Residue number A
345
Residue number B
405
Peptide name
Immunoglobulin heavy constant epsilon
Ligandability
Cysteine 345 of Immunoglobulin heavy constant epsilon
Cysteine 405 of Immunoglobulin heavy constant epsilon
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