Immunoglobulin heavy constant gamma 1
Intermolecular
Cysteine 109 and cysteine 109
Cysteine 112 and cysteine 112
Cysteine 239 of Ig-like domain-containing protein and cysteine 103
Cysteine 105 of Immunoglobulin lambda constant 1 and cysteine 103
Cysteine 107 of Immunoglobulin kappa constant and cysteine 103
Cysteine 250 and cysteine 112
Cysteine 308 and cysteine 349
Cysteine 103 and cysteine 349
Intramolecular
Cysteine 308 and cysteine 27
Cysteine 144 and cysteine 204
More...Cysteine 27 and cysteine 96
Cysteine 27 and cysteine 83
Cysteine 244 and cysteine 92
Cysteine 250 and cysteine 308
Cysteine 109 and cysteine 112
Cysteine 349 and cysteine 250
Cysteine 144 and cysteine 302
Cysteine 244 and cysteine 27
Cysteine 103 and cysteine 27
Cysteine 103 and cysteine 308
Cysteine 83 and cysteine 52
Cysteine 292 and cysteine 302
Cysteine 32 and cysteine 52
Cysteine 35 and cysteine 52
5v4e G 226 H 226
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant gamma 1 at cysteines 109 and 109 (226 and 226 respectively in this structure).
Details
Redox score ?
94
PDB code
5v4e
Structure name
engineered human igg fc domain glyco801 (fc801)
Structure deposition date
2017-03-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant gamma 1
Peptide B name
Immunoglobulin heavy constant gamma 1
Peptide A accession
P01857
Peptide B accession
P01857
Peptide A residue number
109
Peptide B residue number
109
Ligandability
1e4k A 229 B 229
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant gamma 1 at cysteines 112 and 112 (229 and 229 respectively in this structure).
Details
Redox score ?
94
PDB code
1e4k
Structure name
crystal structure of soluble human igg1 fc fragment-fc-gamma receptor iii complex
Structure deposition date
2000-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant gamma 1
Peptide B name
Immunoglobulin heavy constant gamma 1
Peptide A accession
P01857
Peptide B accession
P01857
Peptide A residue number
112
Peptide B residue number
112
Ligandability
4nwt L 214 H 230
A redox-regulated disulphide may form between cysteine 239 of Ig-like domain-containing protein and cysteine 103 of Immunoglobulin heavy constant gamma 1 (214 and 230 respectively in this structure).
Details
Redox score ?
92
PDB code
4nwt
Structure name
crystal structure of the anti-human ngf fab ape1531
Structure deposition date
2013-12-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Ig-like domain-containing protein
Peptide B name
Immunoglobulin heavy constant gamma 1
Peptide A accession
Q8TCD0
Peptide B accession
P01857
Peptide A residue number
239
Peptide B residue number
103
Ligandability
Cysteine 239 of Ig-like domain-containing protein
Cysteine 103 of Immunoglobulin heavy constant gamma 1
1aqk L 215 H 226
A redox-regulated disulphide may form between cysteine 105 of Immunoglobulin lambda constant 1 and cysteine 103 of Immunoglobulin heavy constant gamma 1 (215 and 226 respectively in this structure).
Details
Redox score ?
92
PDB code
1aqk
Structure name
three-dimensional structure of a human fab with high affinity for tetanus toxoid
Structure deposition date
1997-07-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin lambda constant 1
Peptide B name
Immunoglobulin heavy constant gamma 1
Peptide A accession
P01842
Peptide B accession
P01857
Peptide A residue number
105
Peptide B residue number
103
Ligandability
Cysteine 105 of Immunoglobulin lambda constant 1
Cysteine 103 of Immunoglobulin heavy constant gamma 1
1i7z C 214 D 228
A redox-regulated disulphide may form between cysteine 107 of Immunoglobulin kappa constant and cysteine 103 of Immunoglobulin heavy constant gamma 1 (214 and 228 respectively in this structure).
Details
Redox score ?
70
PDB code
1i7z
Structure name
antibody gnc92h2 bound to ligand
Structure deposition date
2001-03-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide A name
Immunoglobulin kappa constant
Peptide B name
Immunoglobulin heavy constant gamma 1
Peptide A accession
P01834
Peptide B accession
P01857
Peptide A residue number
107
Peptide B residue number
103
Ligandability
Cysteine 107 of Immunoglobulin kappa constant
Cysteine 103 of Immunoglobulin heavy constant gamma 1
4x99 A 367 B 354
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant gamma 1 at cysteines 250 and 112 (367 and 354 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
4x99
Structure name
immunoglobulin fc heterodimers variant
Structure deposition date
2014-12-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant gamma 1
Peptide B name
Immunoglobulin heavy constant gamma 1
Peptide A accession
P01857
Peptide B accession
P01857
Peptide A residue number
250
Peptide B residue number
112
Ligandability
Cysteine 250 of Immunoglobulin heavy constant gamma 1
Cysteine 112 of Immunoglobulin heavy constant gamma 1
Uncertain whether structure cysteine 354 has been assigned to correct residue.
5hyi A 425 B 349
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant gamma 1 at cysteines 308 and 349 (425 and 349 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
5hyi
Structure name
glycosylated, disulfide-linked hole-hole fc fragment
Structure deposition date
2016-02-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant gamma 1
Peptide B name
Immunoglobulin heavy constant gamma 1
Peptide A accession
P01857
Peptide B accession
P01857
Peptide A residue number
308
Peptide B residue number
349
Ligandability
Cysteine 308 of Immunoglobulin heavy constant gamma 1
Cysteine 349 of Immunoglobulin heavy constant gamma 1
Cysteine 349 in protein B could not be asigned to a Uniprot residue.
3wn5 D 356 E 349
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant gamma 1 at cysteines 103 and 349 (356 and 349 respectively in this structure).
Details
Redox score ?
nan
PDB code
3wn5
Structure name
crystal structure of asymmetrically engineered fc variant in complex with fcgriiia
Structure deposition date
2013-12-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant gamma 1
Peptide B name
Immunoglobulin heavy constant gamma 1
Peptide A accession
P01857
Peptide B accession
P01857
Peptide A residue number
103
Peptide B residue number
349
Ligandability
Cysteine 103 of Immunoglobulin heavy constant gamma 1
Cysteine 349 of Immunoglobulin heavy constant gamma 1
Cysteine 349 in protein B could not be asigned to a Uniprot residue.
5k8d B 2174 B 2326
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 1 between cysteines 308 and 27 (2174 and 2326 respectively in this structure).
Details
Redox score ?
81
PDB code
5k8d
Structure name
crystal structure of rfviiifc
Structure deposition date
2016-05-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01857
Residue number A
308
Residue number B
27
Peptide name
Immunoglobulin heavy constant gamma 1
Ligandability
Cysteine 308 of Immunoglobulin heavy constant gamma 1
Cysteine 27 of Immunoglobulin heavy constant gamma 1
Uncertain whether structure cysteine 2174 has been assigned to correct residue.
4x4m B 261 B 321
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 1 between cysteines 144 and 204 (261 and 321 respectively in this structure).
Details
Redox score ?
80
PDB code
4x4m
Structure name
structure of fcgammari in complex with fc reveals the importance of glycan recognition for high affinity igg binding
Structure deposition date
2014-12-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01857
Residue number A
144
Residue number B
204
Peptide name
Immunoglobulin heavy constant gamma 1
Ligandability
Cysteine 144 of Immunoglobulin heavy constant gamma 1
Cysteine 204 of Immunoglobulin heavy constant gamma 1
1fbi H 22 H 96
A redox-regulated disulphide may form within Ig gamma-1 chain C region secreted form between cysteines 27 and 96 (22 and 96 respectively in this structure).
Details
Redox score ?
80
PDB code
1fbi
Structure name
crystal structure of a cross-reaction complex between fab f9
Structure deposition date
1995-01-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01868
Residue number A
27
Residue number B
96
Peptide name
Ig gamma-1 chain C region secreted form
Ligandability
Cysteine 27 of Ig gamma-1 chain C region secreted form
Cysteine 96 of Ig gamma-1 chain C region secreted form
Cysteine 96 in protein B could not be asigned to a Uniprot residue.
5iq9 A 140 A 196
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 1 between cysteines 27 and 83 (140 and 196 respectively in this structure).
Details
Redox score ?
80
PDB code
5iq9
Structure name
crystal structure of 10e8v4 fab in complex with an hiv-1 gp41 peptide
Structure deposition date
2016-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01857
Residue number A
27
Residue number B
83
Peptide name
Immunoglobulin heavy constant gamma 1
Ligandability
Cysteine 27 of Immunoglobulin heavy constant gamma 1
Cysteine 83 of Immunoglobulin heavy constant gamma 1
1ai1 H 22 H 92
A redox-regulated disulphide may form within Ig gamma-1 chain C region secreted form between cysteines 244 and 92 (22 and 92 respectively in this structure).
Details
Redox score ?
80
PDB code
1ai1
Structure name
hiv-1 v3 loop mimic
Structure deposition date
1996-11-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01868
Residue number A
244
Residue number B
92
Peptide name
Ig gamma-1 chain C region secreted form
Ligandability
Cysteine 244 of Ig gamma-1 chain C region secreted form
Cysteine 92 of Ig gamma-1 chain C region secreted form
Cysteine 92 in protein B could not be asigned to a Uniprot residue.
5kwg A 367 A 425
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 1 between cysteines 250 and 308 (367 and 425 respectively in this structure).
Details
Redox score ?
73
PDB code
5kwg
Structure name
crystal structure of extracellular domain of her2 in complex with fcab h10-03-6
Structure deposition date
2016-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
77
Peptide accession
P01857
Residue number A
250
Residue number B
308
Peptide name
Immunoglobulin heavy constant gamma 1
Ligandability
Cysteine 250 of Immunoglobulin heavy constant gamma 1
Cysteine 308 of Immunoglobulin heavy constant gamma 1
3sgj A 226 A 229
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 1 between cysteines 109 and 112 (226 and 229 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
3sgj
Structure name
unique carbohydrate-carbohydrate interactions are required for high affinity binding between fcgiii and antibodies lacking core fucose
Structure deposition date
2011-06-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01857
Residue number A
109
Residue number B
112
Peptide name
Immunoglobulin heavy constant gamma 1
Ligandability
Cysteine 109 of Immunoglobulin heavy constant gamma 1
Cysteine 112 of Immunoglobulin heavy constant gamma 1
4x99 A 349 A 367
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 1 between cysteines 349 and 250 (349 and 367 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
4x99
Structure name
immunoglobulin fc heterodimers variant
Structure deposition date
2014-12-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01857
Residue number A
349
Residue number B
250
Peptide name
Immunoglobulin heavy constant gamma 1
Ligandability
Cysteine 349 of Immunoglobulin heavy constant gamma 1
Cysteine 250 of Immunoglobulin heavy constant gamma 1
Cysteine 349 in protein A could not be asigned to a Uniprot residue.
7lur A 261 A 302
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 1 between cysteines 144 and 302 (261 and 302 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7lur
Structure name
stable effector functionless 2 (sefl2) igg1 fc scaffold bound to a minimized version of the b-domain (mini-z) from protein a called z34c
Structure deposition date
2021-02-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01857
Residue number A
144
Residue number B
302
Peptide name
Immunoglobulin heavy constant gamma 1
Ligandability
Cysteine 144 of Immunoglobulin heavy constant gamma 1
Cysteine 302 of Immunoglobulin heavy constant gamma 1
Cysteine 302 in protein B could not be asigned to a Uniprot residue.
1kem H 22 H 98
A redox-regulated disulphide may form within Ig gamma-1 chain C region secreted form between cysteines 244 and 27 (22 and 98 respectively in this structure).
Details
Redox score ?
nan
PDB code
1kem
Structure name
catalytic antibody 28b4 fab fragment
Structure deposition date
1996-04-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01868
Residue number A
244
Residue number B
27
Peptide name
Ig gamma-1 chain C region secreted form
Ligandability
Cysteine 244 of Ig gamma-1 chain C region secreted form
Cysteine 27 of Ig gamma-1 chain C region secreted form
Uncertain whether structure cysteine 98 has been assigned to correct residue.
5k8d B 2169 B 2326
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 1 between cysteines 103 and 27 (2169 and 2326 respectively in this structure).
Details
Redox score ?
nan
PDB code
5k8d
Structure name
crystal structure of rfviiifc
Structure deposition date
2016-05-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01857
Residue number A
103
Residue number B
27
Peptide name
Immunoglobulin heavy constant gamma 1
Ligandability
Cysteine 103 of Immunoglobulin heavy constant gamma 1
Cysteine 27 of Immunoglobulin heavy constant gamma 1
Uncertain whether structure cysteine 2169 has been assigned to correct residue.
5k8d B 2169 B 2174
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 1 between cysteines 103 and 308 (2169 and 2174 respectively in this structure).
Details
Redox score ?
nan
PDB code
5k8d
Structure name
crystal structure of rfviiifc
Structure deposition date
2016-05-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01857
Residue number A
103
Residue number B
308
Peptide name
Immunoglobulin heavy constant gamma 1
Ligandability
Cysteine 103 of Immunoglobulin heavy constant gamma 1
Cysteine 308 of Immunoglobulin heavy constant gamma 1
Uncertain whether structure cysteine 2169 has been assigned to correct residue.
Uncertain whether structure cysteine 2174 has been assigned to correct residue.
3tyg H 32 H 52
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 1 between cysteines 83 and 52 (32 and 52 respectively in this structure).
Details
Redox score ?
nan
PDB code
3tyg
Structure name
crystal structure of broad and potent hiv-1 neutralizing antibody pgt128 in complex with a glycosylated engineered gp120 outer domain with miniv3 (eodmv3)
Structure deposition date
2011-09-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01857
Residue number A
83
Residue number B
52
Peptide name
Immunoglobulin heavy constant gamma 1
Ligandability
Cysteine 83 of Immunoglobulin heavy constant gamma 1
Cysteine 52 of Immunoglobulin heavy constant gamma 1
Uncertain whether structure cysteine 32 has been assigned to correct residue.
Cysteine 52 in protein B could not be asigned to a Uniprot residue.
7lur A 292 A 302
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 1 between cysteines 292 and 302.
Details
Redox score ?
nan
PDB code
7lur
Structure name
stable effector functionless 2 (sefl2) igg1 fc scaffold bound to a minimized version of the b-domain (mini-z) from protein a called z34c
Structure deposition date
2021-02-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01857
Residue number A
292
Residue number B
302
Peptide name
Immunoglobulin heavy constant gamma 1
Ligandability
Cysteine 292 of Immunoglobulin heavy constant gamma 1
Cysteine 302 of Immunoglobulin heavy constant gamma 1
Cysteine 292 in protein A could not be asigned to a Uniprot residue.
Cysteine 302 in protein B could not be asigned to a Uniprot residue.
3twc H 32 H 52
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 1 between cysteines 32 and 52.
Details
Redox score ?
nan
PDB code
3twc
Structure name
crystal structure of broad and potent hiv-1 neutralizing antibody pgt127 in complex with man9
Structure deposition date
2011-09-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01857
Residue number A
32
Residue number B
52
Peptide name
Immunoglobulin heavy constant gamma 1
Ligandability
Cysteine 32 of Immunoglobulin heavy constant gamma 1
Cysteine 52 of Immunoglobulin heavy constant gamma 1
Cysteine 32 in protein A could not be asigned to a Uniprot residue.
Cysteine 52 in protein B could not be asigned to a Uniprot residue.
1ai1 H 35 H 52
A redox-regulated disulphide may form within Ig gamma-1 chain C region secreted form between cysteines 35 and 52.
Details
Redox score ?
nan
PDB code
1ai1
Structure name
hiv-1 v3 loop mimic
Structure deposition date
1996-11-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01868
Residue number A
35
Residue number B
52
Peptide name
Ig gamma-1 chain C region secreted form
Ligandability
Cysteine 35 of Ig gamma-1 chain C region secreted form
Cysteine 52 of Ig gamma-1 chain C region secreted form
Cysteine 35 in protein A could not be asigned to a Uniprot residue.
Cysteine 52 in protein B could not be asigned to a Uniprot residue.
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