ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Immunoglobulin heavy constant gamma 2

Intramolecular
Cysteine 140 and cysteine 200
Cysteine 246 and cysteine 304
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 2 between cysteines 140 and 200 (261 and 321 respectively in this structure).

Details

Redox score ?
80
PDB code
4haf
Structure name
crystal structure of fc-fragment of human igg2 antibody (primitive crystal form)
Structure deposition date
2012-09-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01859
Residue number A
140
Residue number B
200
Peptide name
Immunoglobulin heavy constant gamma 2

Ligandability

Cysteine 140 of Immunoglobulin heavy constant gamma 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Immunoglobulin heavy constant gamma 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 2 between cysteines 246 and 304 (367 and 425 respectively in this structure).

Details

Redox score ?
79
PDB code
7lus
Structure name
igg2 fc charge pair mutation version 1 (cpmv1)
Structure deposition date
2021-02-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01859
Residue number A
246
Residue number B
304
Peptide name
Immunoglobulin heavy constant gamma 2

Ligandability

Cysteine 246 of Immunoglobulin heavy constant gamma 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 304 of Immunoglobulin heavy constant gamma 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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