ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig gamma-3 chain C region

Intramolecular
Cysteine 26 and cysteine 81
Cysteine 191 and cysteine 251
Cysteine 297 and cysteine 355
Cysteine 143 and cysteine 92
A redox-regulated disulphide may form within Ig gamma-3 chain C region between cysteines 26 and 81 (142 and 208 respectively in this structure).

Details

Redox score ?
80
PDB code
1clz
Structure name
igg fab (igg3, kappa) fragment (mbr96) complexed with lewis y nonoate methyl ester
Structure deposition date
1995-03-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22436
Residue number A
26
Residue number B
81
Peptide name
Ig gamma-3 chain C region

Ligandability

Cysteine 26 of Ig gamma-3 chain C region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Ig gamma-3 chain C region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 3 between cysteines 191 and 251 (261 and 321 respectively in this structure).

Details

Redox score ?
74
PDB code
4wwi
Structure name
crystal structure of the c domain of staphylococcal protein a in complex with the fc fragment of human igg at 2
Structure deposition date
2014-11-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
38
Peptide accession
P01860
Residue number A
191
Residue number B
251
Peptide name
Immunoglobulin heavy constant gamma 3

Ligandability

Cysteine 191 of Immunoglobulin heavy constant gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 251 of Immunoglobulin heavy constant gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 3 between cysteines 297 and 355 (367 and 425 respectively in this structure).

Details

Redox score ?
69
PDB code
4wwi
Structure name
crystal structure of the c domain of staphylococcal protein a in complex with the fc fragment of human igg at 2
Structure deposition date
2014-11-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
100
Peptide accession
P01860
Residue number A
297
Residue number B
355
Peptide name
Immunoglobulin heavy constant gamma 3

Ligandability

Cysteine 297 of Immunoglobulin heavy constant gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 355 of Immunoglobulin heavy constant gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig gamma-3 chain C region between cysteines 143 and 92 (22 and 92 respectively in this structure).

Details

Redox score ?
nan
PDB code
1clz
Structure name
igg fab (igg3, kappa) fragment (mbr96) complexed with lewis y nonoate methyl ester
Structure deposition date
1995-03-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22436
Residue number A
143
Residue number B
92
Peptide name
Ig gamma-3 chain C region

Ligandability

Cysteine 143 of Ig gamma-3 chain C region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of Ig gamma-3 chain C region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 in protein B could not be asigned to a Uniprot residue.
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