Immunoglobulin heavy constant gamma 4
Intramolecular
Cysteine 141 and cysteine 201
Cysteine 27 and cysteine 83
Cysteine 247 and cysteine 305
Cysteine 305 and cysteine 437
Cysteine 247 and cysteine 437
Cysteine 247 and cysteine 27
Cysteine 432 and cysteine 437
1adq A 261 A 321
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 4 between cysteines 141 and 201 (261 and 321 respectively in this structure).
Details
Redox score ?
81
PDB code
1adq
Structure name
crystal structure of a human igm rheumatoid factor fab in complex with its autoantigen igg fc
Structure deposition date
1997-02-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01861
Residue number A
141
Residue number B
201
Peptide name
Immunoglobulin heavy constant gamma 4
Ligandability
Cysteine 141 of Immunoglobulin heavy constant gamma 4
Cysteine 201 of Immunoglobulin heavy constant gamma 4
1bbj B 141 B 197
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 4 between cysteines 27 and 83 (141 and 197 respectively in this structure).
Details
Redox score ?
81
PDB code
1bbj
Structure name
crystal structure of a chimeric fab' fragment of an antibody binding tumour cells
Structure deposition date
1992-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01861
Residue number A
27
Residue number B
83
Peptide name
Immunoglobulin heavy constant gamma 4
Ligandability
Cysteine 27 of Immunoglobulin heavy constant gamma 4
Cysteine 83 of Immunoglobulin heavy constant gamma 4
4d2n A 367 A 425
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 4 between cysteines 247 and 305 (367 and 425 respectively in this structure).
Details
Redox score ?
79
PDB code
4d2n
Structure name
crystal structure of deglycosylated serum-derived human igg4 fc
Structure deposition date
2014-05-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01861
Residue number A
247
Residue number B
305
Peptide name
Immunoglobulin heavy constant gamma 4
Ligandability
Cysteine 247 of Immunoglobulin heavy constant gamma 4
Cysteine 305 of Immunoglobulin heavy constant gamma 4
6wib A 425 A 437
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 4 between cysteines 305 and 437 (425 and 437 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6wib
Structure name
next generation monomeric igg4 fc
Structure deposition date
2020-04-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01861
Residue number A
305
Residue number B
437
Peptide name
Immunoglobulin heavy constant gamma 4
Ligandability
Cysteine 305 of Immunoglobulin heavy constant gamma 4
Cysteine 437 of Immunoglobulin heavy constant gamma 4
Cysteine 437 in protein B could not be asigned to a Uniprot residue.
6wib A 367 A 437
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 4 between cysteines 247 and 437 (367 and 437 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6wib
Structure name
next generation monomeric igg4 fc
Structure deposition date
2020-04-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01861
Residue number A
247
Residue number B
437
Peptide name
Immunoglobulin heavy constant gamma 4
Ligandability
Cysteine 247 of Immunoglobulin heavy constant gamma 4
Cysteine 437 of Immunoglobulin heavy constant gamma 4
Cysteine 437 in protein B could not be asigned to a Uniprot residue.
1bbj H 22 H 96
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 4 between cysteines 247 and 27 (22 and 96 respectively in this structure).
Details
Redox score ?
nan
PDB code
1bbj
Structure name
crystal structure of a chimeric fab' fragment of an antibody binding tumour cells
Structure deposition date
1992-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01861
Residue number A
247
Residue number B
27
Peptide name
Immunoglobulin heavy constant gamma 4
Ligandability
Cysteine 247 of Immunoglobulin heavy constant gamma 4
Cysteine 27 of Immunoglobulin heavy constant gamma 4
Uncertain whether structure cysteine 96 has been assigned to correct residue.
6wol H 432 H 437
A redox-regulated disulphide may form within Immunoglobulin heavy constant gamma 4 between cysteines 432 and 437.
Details
Redox score ?
nan
PDB code
6wol
Structure name
next generation monomeric igg4 fc bound to neonatal fc receptor
Structure deposition date
2020-04-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01861
Residue number A
432
Residue number B
437
Peptide name
Immunoglobulin heavy constant gamma 4
Ligandability
Cysteine 432 of Immunoglobulin heavy constant gamma 4
Cysteine 437 of Immunoglobulin heavy constant gamma 4
Cysteine 432 in protein A could not be asigned to a Uniprot residue.
Cysteine 437 in protein B could not be asigned to a Uniprot residue.
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