Immunoglobulin heavy constant mu
Intermolecular
Cysteine 452 and cysteine 91 of Immunoglobulin J chain
Cysteine 235 of IGK@ protein and cysteine 14
Cysteine 214 and cysteine 214
Cysteine 452 and cysteine 452
Cysteine 13 and cysteine 233 of Anti-human Langerin 2G3 lambda chain
Cysteine 37 of Immunoglobulin J chain and cysteine 452
Cysteine 291 and cysteine 291
Cysteine 291 and cysteine 486 of Polymeric immunoglobulin receptor
Cysteine 35 of Immunoglobulin J chain and cysteine 452
Cysteine 452 and cysteine 123 of Immunoglobulin J chain
More...Intramolecular
Cysteine 244 and cysteine 303
Cysteine 245 and cysteine 304
Cysteine 351 and cysteine 351
Cysteine 245 and cysteine 115
Cysteine 351 and cysteine 413
Cysteine 134 and cysteine 197
Cysteine 28 and cysteine 88
6kxs A 575 J 68
A redox-regulated disulphide may form between cysteine 452 of Immunoglobulin heavy constant mu and cysteine 91 of Immunoglobulin J chain (575 and 68 respectively in this structure).
Details
Redox score ?
88
PDB code
6kxs
Structure name
cryo-em structure of human igm-fc in complex with the j chain and the ectodomain of pigr
Structure deposition date
2019-09-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant mu
Peptide B name
Immunoglobulin J chain
Peptide A accession
P01871
Peptide B accession
P01591
Peptide A residue number
452
Peptide B residue number
91
Ligandability
Cysteine 452 of Immunoglobulin heavy constant mu
Cysteine 91 of Immunoglobulin J chain
2agj L 215 H 134
A redox-regulated disulphide may form between cysteine 235 of IGK@ protein and cysteine 14 of Immunoglobulin heavy constant mu (215 and 134 respectively in this structure).
Details
Redox score ?
85
PDB code
2agj
Structure name
crystal structure of a glycosylated fab from an igm cryoglobulin with properties of a natural proteolytic antibody
Structure deposition date
2005-07-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
IGK@ protein
Peptide B name
Immunoglobulin heavy constant mu
Peptide A accession
Q6PJF2
Peptide B accession
P01871
Peptide A residue number
235
Peptide B residue number
14
Ligandability
Cysteine 235 of IGK@ protein
Cysteine 14 of Immunoglobulin heavy constant mu
7xt6 B 350 D 350
A redox-regulated disulphide may form between two units of Isoform 2 of Immunoglobulin heavy constant mu at cysteines 214 and 214 (350 and 350 respectively in this structure).
Details
Redox score ?
84
PDB code
7xt6
Structure name
structure of a membrane protein m3
Structure deposition date
2022-05-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide A name
Isoform 2 of Immunoglobulin heavy constant mu
Peptide B name
Isoform 2 of Immunoglobulin heavy constant mu
Peptide A accession
P01871-2
Peptide B accession
P01871-2
Peptide A residue number
214
Peptide B residue number
214
Ligandability
7ysg H 575 K 575
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant mu at cysteines 452 and 452 (575 and 575 respectively in this structure).
Details
Redox score ?
84
PDB code
7ysg
Structure name
cryo-em structure of human fcmr bound to sigm
Structure deposition date
2022-08-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant mu
Peptide B name
Immunoglobulin heavy constant mu
Peptide A accession
P01871
Peptide B accession
P01871
Peptide A residue number
452
Peptide B residue number
452
Ligandability
8ema B 153 L 233
A redox-regulated disulphide may form between cysteine 13 of Isoform 2 of Immunoglobulin heavy constant mu and cysteine 233 of Anti-human Langerin 2G3 lambda chain (153 and 233 respectively in this structure).
Details
Redox score ?
84
PDB code
8ema
Structure name
mouse full length b cell receptor
Structure deposition date
2022-09-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide A name
Isoform 2 of Immunoglobulin heavy constant mu
Peptide B name
Anti-human Langerin 2G3 lambda chain
Peptide A accession
P01872-2
Peptide B accession
G0YP42
Peptide A residue number
13
Peptide B residue number
233
Ligandability
Cysteine 13 of Isoform 2 of Immunoglobulin heavy constant mu
Cysteine 233 of Anti-human Langerin 2G3 lambda chain
7ytc J 14 L 575
A redox-regulated disulphide may form between cysteine 37 of Immunoglobulin J chain and cysteine 452 of Immunoglobulin heavy constant mu (14 and 575 respectively in this structure).
Details
Redox score ?
83
PDB code
7ytc
Structure name
cryo-em structure of human fcmr bound to igm-fc/j
Structure deposition date
2022-08-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin J chain
Peptide B name
Immunoglobulin heavy constant mu
Peptide A accession
P01591
Peptide B accession
P01871
Peptide A residue number
37
Peptide B residue number
452
Ligandability
Cysteine 37 of Immunoglobulin J chain
Cysteine 452 of Immunoglobulin heavy constant mu
7ytc B 414 C 414
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant mu at cysteines 291 and 291 (414 and 414 respectively in this structure).
Details
Redox score ?
60
PDB code
7ytc
Structure name
cryo-em structure of human fcmr bound to igm-fc/j
Structure deposition date
2022-08-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
11
% buried
48
Peptide A name
Immunoglobulin heavy constant mu
Peptide B name
Immunoglobulin heavy constant mu
Peptide A accession
P01871
Peptide B accession
P01871
Peptide A residue number
291
Peptide B residue number
291
Ligandability
6kxs L 414 P 468
A redox-regulated disulphide may form between cysteine 291 of Immunoglobulin heavy constant mu and cysteine 486 of Polymeric immunoglobulin receptor (414 and 468 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
6kxs
Structure name
cryo-em structure of human igm-fc in complex with the j chain and the ectodomain of pigr
Structure deposition date
2019-09-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
12
Peptide A name
Immunoglobulin heavy constant mu
Peptide B name
Polymeric immunoglobulin receptor
Peptide A accession
P01871
Peptide B accession
P01833
Peptide A residue number
291
Peptide B residue number
486
Ligandability
Cysteine 291 of Immunoglobulin heavy constant mu
Cysteine 486 of Polymeric immunoglobulin receptor
7ytc J 12 L 575
A redox-regulated disulphide may form between cysteine 35 of Immunoglobulin J chain and cysteine 452 of Immunoglobulin heavy constant mu (12 and 575 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7ytc
Structure name
cryo-em structure of human fcmr bound to igm-fc/j
Structure deposition date
2022-08-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin J chain
Peptide B name
Immunoglobulin heavy constant mu
Peptide A accession
P01591
Peptide B accession
P01871
Peptide A residue number
35
Peptide B residue number
452
Ligandability
Cysteine 35 of Immunoglobulin J chain
Cysteine 452 of Immunoglobulin heavy constant mu
6kxs L 575 J 100
A redox-regulated disulphide may form between cysteine 452 of Immunoglobulin heavy constant mu and cysteine 123 of Immunoglobulin J chain (575 and 100 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6kxs
Structure name
cryo-em structure of human igm-fc in complex with the j chain and the ectodomain of pigr
Structure deposition date
2019-09-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant mu
Peptide B name
Immunoglobulin J chain
Peptide A accession
P01871
Peptide B accession
P01591
Peptide A residue number
452
Peptide B residue number
123
Ligandability
Cysteine 452 of Immunoglobulin heavy constant mu
Cysteine 123 of Immunoglobulin J chain
6kxs B 367 B 426
A redox-regulated disulphide may form within Immunoglobulin heavy constant mu between cysteines 244 and 303 (367 and 426 respectively in this structure).
Details
Redox score ?
81
PDB code
6kxs
Structure name
cryo-em structure of human igm-fc in complex with the j chain and the ectodomain of pigr
Structure deposition date
2019-09-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01871
Residue number A
244
Residue number B
303
Peptide name
Immunoglobulin heavy constant mu
Ligandability
Cysteine 244 of Immunoglobulin heavy constant mu
Cysteine 303 of Immunoglobulin heavy constant mu
8ema A 385 A 444
A redox-regulated disulphide may form within Isoform 2 of Immunoglobulin heavy constant mu between cysteines 245 and 304 (385 and 444 respectively in this structure).
Details
Redox score ?
81
PDB code
8ema
Structure name
mouse full length b cell receptor
Structure deposition date
2022-09-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01872-2
Residue number A
245
Residue number B
304
Peptide name
Isoform 2 of Immunoglobulin heavy constant mu
Ligandability
Cysteine 245 of Isoform 2 of Immunoglobulin heavy constant mu
Cysteine 304 of Isoform 2 of Immunoglobulin heavy constant mu
2agj H 22 H 97
A redox-regulated disulphide may form within Immunoglobulin heavy constant mu between cysteines 351 and 351 (22 and 97 respectively in this structure).
Details
Redox score ?
80
PDB code
2agj
Structure name
crystal structure of a glycosylated fab from an igm cryoglobulin with properties of a natural proteolytic antibody
Structure deposition date
2005-07-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01871
Residue number A
351
Residue number B
351
Peptide name
Immunoglobulin heavy constant mu
Ligandability
Cysteine 351 of Immunoglobulin heavy constant mu
Cysteine 351 of Immunoglobulin heavy constant mu
8ema A 41 A 115
A redox-regulated disulphide may form within Isoform 2 of Immunoglobulin heavy constant mu between cysteines 245 and 115 (41 and 115 respectively in this structure).
Details
Redox score ?
80
PDB code
8ema
Structure name
mouse full length b cell receptor
Structure deposition date
2022-09-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01872-2
Residue number A
245
Residue number B
115
Peptide name
Isoform 2 of Immunoglobulin heavy constant mu
Ligandability
Cysteine 245 of Isoform 2 of Immunoglobulin heavy constant mu
Cysteine 115 of Isoform 2 of Immunoglobulin heavy constant mu
Cysteine 115 in protein B could not be asigned to a Uniprot residue.
7xq8 C 474 C 536
A redox-regulated disulphide may form within Isoform 2 of Immunoglobulin heavy constant mu between cysteines 351 and 413 (474 and 536 respectively in this structure).
Details
Redox score ?
79
PDB code
7xq8
Structure name
structure of human b-cell antigen receptor of the igm isotype
Structure deposition date
2022-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01871-2
Residue number A
351
Residue number B
413
Peptide name
Isoform 2 of Immunoglobulin heavy constant mu
Ligandability
Cysteine 351 of Isoform 2 of Immunoglobulin heavy constant mu
Cysteine 413 of Isoform 2 of Immunoglobulin heavy constant mu
7xq8 v 257 v 320
A redox-regulated disulphide may form within Isoform 2 of Immunoglobulin heavy constant mu between cysteines 134 and 197 (257 and 320 respectively in this structure).
Details
Redox score ?
79
PDB code
7xq8
Structure name
structure of human b-cell antigen receptor of the igm isotype
Structure deposition date
2022-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01871-2
Residue number A
134
Residue number B
197
Peptide name
Isoform 2 of Immunoglobulin heavy constant mu
Ligandability
Cysteine 134 of Isoform 2 of Immunoglobulin heavy constant mu
Cysteine 197 of Isoform 2 of Immunoglobulin heavy constant mu
2agj H 147 H 207
A redox-regulated disulphide may form within Immunoglobulin heavy constant mu between cysteines 28 and 88 (147 and 207 respectively in this structure).
Details
Redox score ?
79
PDB code
2agj
Structure name
crystal structure of a glycosylated fab from an igm cryoglobulin with properties of a natural proteolytic antibody
Structure deposition date
2005-07-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01871
Residue number A
28
Residue number B
88
Peptide name
Immunoglobulin heavy constant mu
Ligandability
Cysteine 28 of Immunoglobulin heavy constant mu
Cysteine 88 of Immunoglobulin heavy constant mu
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