Immunoglobulin heavy constant alpha 1
Intermolecular
Cysteine 352 and cysteine 37 of Immunoglobulin J chain
Cysteine 352 and cysteine 91 of Immunoglobulin J chain
Cysteine 182 and cysteine 122
Cysteine 180 and cysteine 122
Cysteine 192 and cysteine 486 of Polymeric immunoglobulin receptor
Cysteine 180 and cysteine 123
Cysteine 180 and cysteine 182
Cysteine 180 and cysteine 180
Cysteine 123 and cysteine 123
Cysteine 182 and cysteine 182
More...Cysteine 352 and cysteine 35 of Immunoglobulin J chain
Intramolecular
Cysteine 147 and cysteine 204
Cysteine 250 and cysteine 313
Cysteine 122 and cysteine 123
Cysteine 123 and cysteine 182
6lx3 D 471 J 14
A redox-regulated disulphide may form between cysteine 352 of Immunoglobulin heavy constant alpha 1 and cysteine 37 of Immunoglobulin J chain (471 and 14 respectively in this structure).
Details
Redox score ?
82
PDB code
6lx3
Structure name
cryo-em structure of human secretory immunoglobulin a
Structure deposition date
2020-02-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin J chain
Peptide A accession
P01876
Peptide B accession
P01591
Peptide A residue number
352
Peptide B residue number
37
Ligandability
Cysteine 352 of Immunoglobulin heavy constant alpha 1
Cysteine 37 of Immunoglobulin J chain
6ue7 B 471 D 69
A redox-regulated disulphide may form between cysteine 352 of Immunoglobulin heavy constant alpha 1 and cysteine 91 of Immunoglobulin J chain (471 and 69 respectively in this structure).
Details
Redox score ?
80
PDB code
6ue7
Structure name
structure of dimeric siga complex
Structure deposition date
2019-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin J chain
Peptide A accession
P01876
Peptide B accession
P01591
Peptide A residue number
352
Peptide B residue number
91
Ligandability
Cysteine 352 of Immunoglobulin heavy constant alpha 1
Cysteine 91 of Immunoglobulin J chain
6xja A 301 B 241
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant alpha 1 at cysteines 182 and 122 (301 and 241 respectively in this structure).
Details
Redox score ?
78
PDB code
6xja
Structure name
streptococcus pneumoniae iga1 protease with iga1 substrate
Structure deposition date
2020-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin heavy constant alpha 1
Peptide A accession
P01876
Peptide B accession
P01876
Peptide A residue number
182
Peptide B residue number
122
Ligandability
Cysteine 182 of Immunoglobulin heavy constant alpha 1
Cysteine 122 of Immunoglobulin heavy constant alpha 1
6xja A 299 B 241
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant alpha 1 at cysteines 180 and 122 (299 and 241 respectively in this structure).
Details
Redox score ?
73
PDB code
6xja
Structure name
streptococcus pneumoniae iga1 protease with iga1 substrate
Structure deposition date
2020-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
11
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin heavy constant alpha 1
Peptide A accession
P01876
Peptide B accession
P01876
Peptide A residue number
180
Peptide B residue number
122
Ligandability
Cysteine 180 of Immunoglobulin heavy constant alpha 1
Cysteine 122 of Immunoglobulin heavy constant alpha 1
6lx3 D 311 P 468
A redox-regulated disulphide may form between cysteine 192 of Immunoglobulin heavy constant alpha 1 and cysteine 486 of Polymeric immunoglobulin receptor (311 and 468 respectively in this structure).
Details
Redox score ?
65
PDB code
6lx3
Structure name
cryo-em structure of human secretory immunoglobulin a
Structure deposition date
2020-02-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
45
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Polymeric immunoglobulin receptor
Peptide A accession
P01876
Peptide B accession
P01833
Peptide A residue number
192
Peptide B residue number
486
Ligandability
Cysteine 192 of Immunoglobulin heavy constant alpha 1
Cysteine 486 of Polymeric immunoglobulin receptor
2qej A 299 B 242
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant alpha 1 at cysteines 180 and 123 (299 and 242 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
2qej
Structure name
crystal structure of a staphylococcus aureus protein (ssl7) in complex with fc of human iga1
Structure deposition date
2007-06-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin heavy constant alpha 1
Peptide A accession
P01876
Peptide B accession
P01876
Peptide A residue number
180
Peptide B residue number
123
Ligandability
Cysteine 180 of Immunoglobulin heavy constant alpha 1
Cysteine 123 of Immunoglobulin heavy constant alpha 1
2qej A 299 B 301
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant alpha 1 at cysteines 180 and 182 (299 and 301 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
2qej
Structure name
crystal structure of a staphylococcus aureus protein (ssl7) in complex with fc of human iga1
Structure deposition date
2007-06-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin heavy constant alpha 1
Peptide A accession
P01876
Peptide B accession
P01876
Peptide A residue number
180
Peptide B residue number
182
Ligandability
Cysteine 180 of Immunoglobulin heavy constant alpha 1
Cysteine 182 of Immunoglobulin heavy constant alpha 1
1ow0 A 299 B 299
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant alpha 1 at cysteines 180 and 180 (299 and 299 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
1ow0
Structure name
crystal structure of human fcari bound to iga1-fc
Structure deposition date
2003-03-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin heavy constant alpha 1
Peptide A accession
P01876
Peptide B accession
P01876
Peptide A residue number
180
Peptide B residue number
180
Ligandability
6ue7 A 242 B 242
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant alpha 1 at cysteines 123 and 123 (242 and 242 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
6ue7
Structure name
structure of dimeric siga complex
Structure deposition date
2019-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin heavy constant alpha 1
Peptide A accession
P01876
Peptide B accession
P01876
Peptide A residue number
123
Peptide B residue number
123
Ligandability
6lxw C 301 D 301
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant alpha 1 at cysteines 182 and 182 (301 and 301 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6lxw
Structure name
cryo-em structure of human secretory immunoglobulin a in complex with the n-terminal domain of spsa
Structure deposition date
2020-02-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
0
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin heavy constant alpha 1
Peptide A accession
P01876
Peptide B accession
P01876
Peptide A residue number
182
Peptide B residue number
182
Ligandability
6ue7 F 471 D 13
A redox-regulated disulphide may form between cysteine 352 of Immunoglobulin heavy constant alpha 1 and cysteine 35 of Immunoglobulin J chain (471 and 13 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6ue7
Structure name
structure of dimeric siga complex
Structure deposition date
2019-09-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 1
Peptide B name
Immunoglobulin J chain
Peptide A accession
P01876
Peptide B accession
P01591
Peptide A residue number
352
Peptide B residue number
35
Ligandability
Cysteine 352 of Immunoglobulin heavy constant alpha 1
Cysteine 35 of Immunoglobulin J chain
1ow0 B 266 B 323
A redox-regulated disulphide may form within Immunoglobulin heavy constant alpha 1 between cysteines 147 and 204 (266 and 323 respectively in this structure).
Details
Redox score ?
84
PDB code
1ow0
Structure name
crystal structure of human fcari bound to iga1-fc
Structure deposition date
2003-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01876
Residue number A
147
Residue number B
204
Peptide name
Immunoglobulin heavy constant alpha 1
Ligandability
Cysteine 147 of Immunoglobulin heavy constant alpha 1
Cysteine 204 of Immunoglobulin heavy constant alpha 1
1ow0 B 369 B 432
A redox-regulated disulphide may form within Immunoglobulin heavy constant alpha 1 between cysteines 250 and 313 (369 and 432 respectively in this structure).
Details
Redox score ?
78
PDB code
1ow0
Structure name
crystal structure of human fcari bound to iga1-fc
Structure deposition date
2003-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01876
Residue number A
250
Residue number B
313
Peptide name
Immunoglobulin heavy constant alpha 1
Ligandability
Cysteine 250 of Immunoglobulin heavy constant alpha 1
Cysteine 313 of Immunoglobulin heavy constant alpha 1
6xja B 241 B 242
A redox-regulated disulphide may form within Immunoglobulin heavy constant alpha 1 between cysteines 122 and 123 (241 and 242 respectively in this structure).
Details
Redox score ?
74
PDB code
6xja
Structure name
streptococcus pneumoniae iga1 protease with iga1 substrate
Structure deposition date
2020-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
nan
Peptide accession
P01876
Residue number A
122
Residue number B
123
Peptide name
Immunoglobulin heavy constant alpha 1
Ligandability
Cysteine 122 of Immunoglobulin heavy constant alpha 1
Cysteine 123 of Immunoglobulin heavy constant alpha 1
6xja A 242 A 301
A redox-regulated disulphide may form within Immunoglobulin heavy constant alpha 1 between cysteines 123 and 182 (242 and 301 respectively in this structure).
Details
Redox score ?
70
PDB code
6xja
Structure name
streptococcus pneumoniae iga1 protease with iga1 substrate
Structure deposition date
2020-06-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide accession
P01876
Residue number A
123
Residue number B
182
Peptide name
Immunoglobulin heavy constant alpha 1
Ligandability
Cysteine 123 of Immunoglobulin heavy constant alpha 1
Cysteine 182 of Immunoglobulin heavy constant alpha 1
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