Immunoglobulin heavy constant alpha 2
Intermolecular
Cysteine 339 and cysteine 339
Cysteine 486 of Polymeric immunoglobulin receptor and cysteine 179
Cysteine 339 and cysteine 91 of Immunoglobulin J chain
Cysteine 37 of Immunoglobulin J chain and cysteine 339
Cysteine 110 and cysteine 110
Cysteine 167 and cysteine 167
Cysteine 35 of Immunoglobulin J chain and cysteine 339
Intramolecular
Cysteine 237 and cysteine 300
Cysteine 134 and cysteine 191
Cysteine 110 and cysteine 167
6ue8 G 471 E 471
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant alpha 2 at cysteines 339 and 339 (471 and 471 respectively in this structure).
Details
Redox score ?
86
PDB code
6ue8
Structure name
structure of tetrameric siga complex (class 1)
Structure deposition date
2019-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 2
Peptide B name
Immunoglobulin heavy constant alpha 2
Peptide A accession
P01877
Peptide B accession
P01877
Peptide A residue number
339
Peptide B residue number
339
Ligandability
6uea C 468 F 311
A redox-regulated disulphide may form between cysteine 486 of Polymeric immunoglobulin receptor and cysteine 179 of Immunoglobulin heavy constant alpha 2 (468 and 311 respectively in this structure).
Details
Redox score ?
84
PDB code
6uea
Structure name
structure of pentameric siga complex
Structure deposition date
2019-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide A name
Polymeric immunoglobulin receptor
Peptide B name
Immunoglobulin heavy constant alpha 2
Peptide A accession
P01833
Peptide B accession
P01877
Peptide A residue number
486
Peptide B residue number
179
Ligandability
Cysteine 486 of Polymeric immunoglobulin receptor
Cysteine 179 of Immunoglobulin heavy constant alpha 2
6ue9 B 471 D 69
A redox-regulated disulphide may form between cysteine 339 of Immunoglobulin heavy constant alpha 2 and cysteine 91 of Immunoglobulin J chain (471 and 69 respectively in this structure).
Details
Redox score ?
83
PDB code
6ue9
Structure name
structure of tetrameric siga complex (class 2)
Structure deposition date
2019-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 2
Peptide B name
Immunoglobulin J chain
Peptide A accession
P01877
Peptide B accession
P01591
Peptide A residue number
339
Peptide B residue number
91
Ligandability
Cysteine 339 of Immunoglobulin heavy constant alpha 2
Cysteine 91 of Immunoglobulin J chain
6uea D 15 F 471
A redox-regulated disulphide may form between cysteine 37 of Immunoglobulin J chain and cysteine 339 of Immunoglobulin heavy constant alpha 2 (15 and 471 respectively in this structure).
Details
Redox score ?
82
PDB code
6uea
Structure name
structure of pentameric siga complex
Structure deposition date
2019-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin J chain
Peptide B name
Immunoglobulin heavy constant alpha 2
Peptide A accession
P01591
Peptide B accession
P01877
Peptide A residue number
37
Peptide B residue number
339
Ligandability
Cysteine 37 of Immunoglobulin J chain
Cysteine 339 of Immunoglobulin heavy constant alpha 2
6ue9 A 242 B 242
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant alpha 2 at cysteines 110 and 110 (242 and 242 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6ue9
Structure name
structure of tetrameric siga complex (class 2)
Structure deposition date
2019-09-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 2
Peptide B name
Immunoglobulin heavy constant alpha 2
Peptide A accession
P01877
Peptide B accession
P01877
Peptide A residue number
110
Peptide B residue number
110
Ligandability
6ue9 E 299 H 299
A redox-regulated disulphide may form between two units of Immunoglobulin heavy constant alpha 2 at cysteines 167 and 167 (299 and 299 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6ue9
Structure name
structure of tetrameric siga complex (class 2)
Structure deposition date
2019-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin heavy constant alpha 2
Peptide B name
Immunoglobulin heavy constant alpha 2
Peptide A accession
P01877
Peptide B accession
P01877
Peptide A residue number
167
Peptide B residue number
167
Ligandability
6ue8 D 13 F 471
A redox-regulated disulphide may form between cysteine 35 of Immunoglobulin J chain and cysteine 339 of Immunoglobulin heavy constant alpha 2 (13 and 471 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
6ue8
Structure name
structure of tetrameric siga complex (class 1)
Structure deposition date
2019-09-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin J chain
Peptide B name
Immunoglobulin heavy constant alpha 2
Peptide A accession
P01591
Peptide B accession
P01877
Peptide A residue number
35
Peptide B residue number
339
Ligandability
Cysteine 35 of Immunoglobulin J chain
Cysteine 339 of Immunoglobulin heavy constant alpha 2
6ue8 G 369 G 432
A redox-regulated disulphide may form within Immunoglobulin heavy constant alpha 2 between cysteines 237 and 300 (369 and 432 respectively in this structure).
Details
Redox score ?
79
PDB code
6ue8
Structure name
structure of tetrameric siga complex (class 1)
Structure deposition date
2019-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01877
Residue number A
237
Residue number B
300
Peptide name
Immunoglobulin heavy constant alpha 2
Ligandability
Cysteine 237 of Immunoglobulin heavy constant alpha 2
Cysteine 300 of Immunoglobulin heavy constant alpha 2
6ue8 E 266 E 323
A redox-regulated disulphide may form within Immunoglobulin heavy constant alpha 2 between cysteines 134 and 191 (266 and 323 respectively in this structure).
Details
Redox score ?
71
PDB code
6ue8
Structure name
structure of tetrameric siga complex (class 1)
Structure deposition date
2019-09-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
33
Peptide accession
P01877
Residue number A
134
Residue number B
191
Peptide name
Immunoglobulin heavy constant alpha 2
Ligandability
Cysteine 134 of Immunoglobulin heavy constant alpha 2
Cysteine 191 of Immunoglobulin heavy constant alpha 2
6ue8 H 242 H 299
A redox-regulated disulphide may form within Immunoglobulin heavy constant alpha 2 between cysteines 110 and 167 (242 and 299 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6ue8
Structure name
structure of tetrameric siga complex (class 1)
Structure deposition date
2019-09-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01877
Residue number A
110
Residue number B
167
Peptide name
Immunoglobulin heavy constant alpha 2
Ligandability
Cysteine 110 of Immunoglobulin heavy constant alpha 2
Cysteine 167 of Immunoglobulin heavy constant alpha 2
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