ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

HLA class II histocompatibility antigen, DRB1 beta chain

Intramolecular
Cysteine 146 and cysteine 202
Cysteine 44 and cysteine 108
A redox-regulated disulphide may form within HLA class II histocompatibility antigen, DRB1 beta chain between cysteines 146 and 202 (364 and 420 respectively in this structure).

Details

Redox score ?
79
PDB code
5v4m
Structure name
structure of hla-dr15 with bound alpha3(135-145) peptide
Structure deposition date
2017-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01911
Residue number A
146
Residue number B
202
Peptide name
HLA class II histocompatibility antigen, DRB1 beta chain

Ligandability

Cysteine 146 of HLA class II histocompatibility antigen, DRB1 beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of HLA class II histocompatibility antigen, DRB1 beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HLA class II histocompatibility antigen, DRB1 beta chain between cysteines 44 and 108 (262 and 326 respectively in this structure).

Details

Redox score ?
79
PDB code
5v4m
Structure name
structure of hla-dr15 with bound alpha3(135-145) peptide
Structure deposition date
2017-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01911
Residue number A
44
Residue number B
108
Peptide name
HLA class II histocompatibility antigen, DRB1 beta chain

Ligandability

Cysteine 44 of HLA class II histocompatibility antigen, DRB1 beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of HLA class II histocompatibility antigen, DRB1 beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: