ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Hemoglobin subunit delta

Intermolecular
Cysteine 105 of Hemoglobin subunit alpha and cysteine 113
A redox-regulated disulphide may form between cysteine 105 of Hemoglobin subunit alpha and cysteine 113 of Hemoglobin subunit delta (104 and 112 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
1si4
Structure name
crystal structure of human hemoglobin a2 (in r2 state) at 2
Structure deposition date
2004-02-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide A name
Hemoglobin subunit alpha
Peptide B name
Hemoglobin subunit delta
Peptide A accession
P69905
Peptide B accession
P02042
Peptide A residue number
105
Peptide B residue number
113

Ligandability

Cysteine 105 of Hemoglobin subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Hemoglobin subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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